Treatment of invasive candidiasis in non-haematological patients

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SusceptibilityAntfungal Albicans Glabrata Parapsilosis TropicalisKruseiAmB-d S S S S SL-AmB S S S S SFluconazole S (SDD)-R S S Rvoriconazole S SDD-R S S SAnidulafungin S S S/? S SCaspofungin S S S/? S Smicafungin S S S/? S S
Caspofungin vs. Amphotericin B trialTime to First Negative Blood Culture100%90Caspofungin70/50 mgAmphotericin B0.6-1.0 mg/kg8070605040302010Success (MITT) 73% 62% P=0.09n=224Crude Mortality 34% 30% P=0.53ToxicityDiscontinuations3% 23% P=0.03Caspofungin (N=92)Amphotericin B (N=94)00 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24STUDY DAYMora-Duarte NEJM2002
Page 5 and 6: EpidemiologyMainly data from the US
Page 7 and 8: Survival in candidemia, species rel
Page 9 and 10: Question1 : Which Candida species i
Page 11 and 12: Incidence and mortality of Candida
Page 13 and 14: HOW TO IDENTIFY PATIENTSAT RISK FOR
Page 15 and 16: Question 2: Which factor has the gr
Page 17 and 18: Identification of patients“Ostros
Page 19 and 20: Question3: What’s the problem wit
Page 21 and 22: Identification of patients“Ostros
Page 23 and 24: Are the risk predictive models gene
Page 25 and 26: Question 4: Empirical treatment is
Page 27 and 28: HOW TO PREVENT INVASIVECANDIDIASIS
Page 29 and 30: Empirical antifungal therapy in ICU
Page 31 and 32: TREATMENT OF INVASIVECANDIDIASIS
Page 33 and 34: Why do we choose whichantifungal dr
Page 35: Randomized Non-Inferior TrialsAmB v
Page 39 and 40: Micafungin vs. L-AmB in ICU Patient
Page 41 and 42: Anidulafungin vs. fluconazole study
Page 43 and 44: Success rates different echinocandi
Page 45 and 46: Question 5: Should the intravascula
Page 47 and 48: Antifungal agents and survivalCandi
Page 49 and 50: In conclusion• Invasive candidias
Page 51 and 52: Treatment of candidemia-Candida spe
Page 53 and 54: Success at EIV treatment by pathoge
Page 55 and 56: Question 6: Should the intravascula
Page 57 and 58: Candida Scorein practiceProspective

Treatment of invasive candidiasis in non-haematological patients

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