Treatment of invasive candidiasis in non-haematological patients
Treatment of invasive candidiasis in non-haematological patients Treatment of invasive candidiasis in non-haematological patients
Prediction rules- Paphitou: TPN, hemodialysis, diabetes, broadspectrum antibiotics- Ostrosky-Zeichner:- CVC +/- broad spectrum antibioticsand at least 2 of:- TPN, hemodialysis, major surgery, pancreatitis,corticosteroids, immunosuppression- Candida score: Multivariate analysis of risk factorsthat predispose for invasive candidiasis
Identification of patients“Ostrosky rules”≥ 4 days on ICUAND-Antibiotics (d 1-3)OR-CVC (d 1-3)And at least 2 of theseTPN (d 1-3)Dialysis (d 1-3)Major surgery (d -7-0)Use steroids (d -7-3)Immunosupp. (d -7-0)Ostrosky-Zeichner, 2007;26:271
- Page 5 and 6: EpidemiologyMainly data from the US
- Page 7 and 8: Survival in candidemia, species rel
- Page 9 and 10: Question1 : Which Candida species i
- Page 11 and 12: Incidence and mortality of Candida
- Page 13 and 14: HOW TO IDENTIFY PATIENTSAT RISK FOR
- Page 15: Question 2: Which factor has the gr
- Page 19 and 20: Question3: What’s the problem wit
- Page 21 and 22: Identification of patients“Ostros
- Page 23 and 24: Are the risk predictive models gene
- Page 25 and 26: Question 4: Empirical treatment is
- Page 27 and 28: HOW TO PREVENT INVASIVECANDIDIASIS
- Page 29 and 30: Empirical antifungal therapy in ICU
- Page 31 and 32: TREATMENT OF INVASIVECANDIDIASIS
- Page 33 and 34: Why do we choose whichantifungal dr
- Page 35 and 36: Randomized Non-Inferior TrialsAmB v
- Page 37 and 38: Caspofungin vs. Amphotericin B tria
- Page 39 and 40: Micafungin vs. L-AmB in ICU Patient
- Page 41 and 42: Anidulafungin vs. fluconazole study
- Page 43 and 44: Success rates different echinocandi
- Page 45 and 46: Question 5: Should the intravascula
- Page 47 and 48: Antifungal agents and survivalCandi
- Page 49 and 50: In conclusion• Invasive candidias
- Page 51 and 52: Treatment of candidemia-Candida spe
- Page 53 and 54: Success at EIV treatment by pathoge
- Page 55 and 56: Question 6: Should the intravascula
- Page 57 and 58: Candida Scorein practiceProspective
Identification <strong>of</strong> <strong>patients</strong>“Ostrosky rules”≥ 4 days on ICUAND-Antibiotics (d 1-3)OR-CVC (d 1-3)And at least 2 <strong>of</strong> theseTPN (d 1-3)Dialysis (d 1-3)Major surgery (d -7-0)Use steroids (d -7-3)Immunosupp. (d -7-0)Ostrosky-Zeichner, 2007;26:271
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