Guidelines for ATC classification and DDD assignment - WHOCC

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Fixed DDDs are assigned for combinations. These DDDs are based
on an average dose regimen of three times daily, and dosages in the
upper area of the recommended dose ranges are chosen. The
strengths of the various components are not taken into
consideration. E.g. 6 UD (= 30 ml) is the fixed DDD for products
where the recommended dose is 5-10 ml.
R05C EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH
SUPPRESSANTS
This group comprises preparations with expectorants and mucolytics.
Combined preparations are classified at separate 5th levels using the
code number 10. These may also contain bronchodilating agents,
antihistamines etc.
Preparations, which contain small amounts of herbal extracts, menthol
etc., are regarded as plain preparations.
R05CA Expectorants
R05CB Mucolytics
All combined products of expectorants are classified in R05CA10.
Mesna in i.v. formulations used for the prophylaxis of urothelial toxicity
is classified in V03AF. Mesna used as a mucolytic agent (e.g.
administered by a nebuliser) is classified here.
All combined products of mucolytics are classified in R05CB10.
Combinations with xanthines are classified in R03DA.
Combinations with antiinflammatory agents are classified in M01.
For acetylcysteine, the DDD for inhalation solution is higher than
for the oral formulation, due to differences in the dosages
recommended.