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Guidelines for ATC classification and DDD assignment - WHOCC

Guidelines for ATC classification and DDD assignment - WHOCC

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N02A OPIOIDS<br />

This group comprises strong analgesics of the opiate type <strong>and</strong> analgesics<br />

with similar structure or action.<br />

Sufentanil, which is also used as an epidural analgesic, is classified in<br />

N01AH.<br />

Combinations with antispasmodics are classified in N02AG.<br />

The <strong>DDD</strong>s in this group are based on the treatment of pain.<br />

The <strong>DDD</strong> <strong>for</strong> oral morphine is higher than the parenteral <strong>DDD</strong><br />

because of lower bioavailability.<br />

The <strong>DDD</strong> <strong>for</strong> combinations of oxycodone <strong>and</strong> naloxone<br />

(N02AA55) is similar to the <strong>DDD</strong> <strong>for</strong> plain oxycodone.<br />

N02AA Natural opium alkaloids<br />

This group includes natural <strong>and</strong> semi-synthetic opiates.<br />

Opium, see also A07DA - Antipropulsives.<br />

Plain codeine preparations are classified in R05D - Cough suppressants,<br />

excl. combinations with expectorants. Codeine or dihydrocodeine in<br />

combination with other analgesics are classified in this group at separate<br />

5th levels by using the 50-series, if the codeine or dihydrocodeine<br />

content is 20 mg or more per unit dose. Combinations with a lower<br />

content of codeine or dihydrocodeine are classified at the respective 4th<br />

levels in N02B or M01A of the other analgesic components (e.g.<br />

paracetamol or acetylsalicylic acid).<br />

Combinations with antihistamines <strong>and</strong> anticholinergic agents are<br />

classified here.<br />

Combinations of oxycodone <strong>and</strong> naloxone are classified in N02AA55.<br />

207

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