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Guidelines for ATC classification and DDD assignment - WHOCC

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100<br />

Combinations with cardiac glycosides, see C01A.<br />

Combinations with rauwolfia alkaloids, see C02AA.<br />

Combinations with beta blocking agents, see C07.<br />

Combinations with calcium channel blockers, see C08.<br />

C01DA Organic nitrates<br />

This group comprises nitrates used on the indication angina pectoris,<br />

including transdermal preparations. Amyl nitrite is classified in<br />

V03AB - Antidotes.<br />

Combinations of isosorbide dinitrate <strong>and</strong> hydralazine are classified in<br />

C01DA58.<br />

All nitrate preparations in combination with psycholeptics are classified<br />

in C01DA70. Nitrates in combination with psycholeptics <strong>and</strong> other<br />

agents are also given the code C01DA70.<br />

The <strong>DDD</strong>s <strong>for</strong> the nitrates are mainly based on the treatment of<br />

angina pectoris attacks (3-4 times daily). The <strong>DDD</strong>s of<br />

preparations <strong>for</strong> oral <strong>and</strong> transdermal administration are higher than<br />

the <strong>DDD</strong>s <strong>for</strong> other routes of administration (e.g. sublingual) due to<br />

a lower bioavailability.<br />

The <strong>DDD</strong>s <strong>for</strong> some preparations are mainly based on prophylaxis,<br />

<strong>for</strong> instance the <strong>DDD</strong>s of isosorbide dinitrate <strong>and</strong> glyceryl trinitrate<br />

plaster.<br />

No <strong>DDD</strong>s are established <strong>for</strong> parenteral preparations due to great<br />

differences in the dosages used.<br />

C01DB Quinolone vasodilators<br />

C01DX Other vasodilators used in cardiac diseases<br />

This group comprises vasodilators used in cardiac diseases, which<br />

cannot be classified in the preceding groups.

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