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Mark Gudesblatt, MD

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References1. Tan CS, Koralnik IJ. Progressive multifocalleukoencephalopathy and otherdisorders caused by JC virus: clinical featuresand pathogenesis. Lancet Neurol.2010;9(4):425-437.2. Seth P, Diaz F, Major EO. Advances in thebiology of JC virus and induction of progressivemultifocal leukoencephalopathy.J Neurovirol. 2003;9(2):236-246.3. Padgett BL, Walker DL, ZuRhein GM, etal. Cultivation of papova-like virus fromhuman brain with progressive multifocalleucoencephalopathy. Lancet. 1971;1(7712):1257-1260.4. Tyler KL. Progressive multifocal leukoencephalopathy:can we reduce risk inpatients receiving biological immunomodulatorytherapies? Ann Neurol. 2010;68(3):271-274.5. Vermersch P, Kappos L, Gold R, et al. Clinicaloutcomes of natalizumab-associatedprogressive multifocal leukoencephalopathy.Neurology. 2011; 76(20):1697-1704.6. Frisque RJ, Bream GL, Cannella MT. Humanpolyomavirus JC virus genome. JVirol. 1984;51(2):458-469.7. Padgett BL, Walker DL. Prevalence of antibodiesin human sera against JC virus, anisolate from a case of progressive multifocalleukoencephalopathy. J Infect Dis.1973;127(4):467-470.8. Matos A, Duque V, Beato S, et al. Characterizationof JC human polyomavirus infectionin a Portuguese population. J MedVirol. 2010;82(3):494-504.9. Kunitake T, Kitamura T, Guo J, et al. Parent-to-childtransmission is relativelycommon in the spread of the humanpolyomavirus JC virus. J Clin Microbiol.1995;33(6):1448-1451.10. Boothpur R, Brennan DC. Human polyomaviruses and disease with emphasison clinical BK and JC. J Clin Virol.2010;47(4):306-312.11. Monaco MC, Jensen PN, Hou J, et al. Detectionof JC virus DNA in human tonsiltissue: evidence for site of initial viral infection.J Virol. 1998;72(12):9918-9923.12. Tan CS, Ellis LC, Wüthrich C, et al. JC viruslatency in the brain and extraneural organsof patients with and without progressivemultifocal leukoencephalopathy.J Virol. 2010;84(18):9200-9209.13. Komagome R, Sawa H, Suzuki T, et al. Oligosaccharidesas receptors for JC virus. JVirol. 2002;76(24):12992-13000.14. Elphick GF, Querbes W, Jordan JA, et al.The human polyomavirus, JCV, uses serotoninreceptors to infect cells. Science.2004;306(5700):1380-1383.15. Pho MT, Ashok A, Atwood WJ. JC virusenters human glial cells by clathrin-dependentreceptor-mediated endocytosis.J Virol. 2000;74(5):2288-2292.16. Shackelton LA, Rambaut A, Pybus OG,Holmes EC. JC virus evolution and its associationwith human populations. J Virol.2006;80(20):9928-9933.17. Dubois V, Moret H, Lafon ME, et al. JCvirus genotypes in France: molecularepidemiology and potential significancefor progressive multifocal leukoencephalopathy.J Infect Dis. 2001;183(2):213-217.18. Pfister LA, Letvin NL, Koralnik IJ. JC virusregulatory region tandem repeats inplasma and central nervous system isolatescorrelate with poor clinical outcomein patients with progressive multifocalleukoencephalopathy. J Virol. 2001;75(12):5672-5676.19. Agostini HT, Ryschkewitsch CF, Singer EJ,Stoner GL. JC virus regulatory region rearrangementsand genotypes in progressivemultifocal leukoencephalopathy:two independent aspects of virus variation.J Gen Virol. 1997;78(Pt 3):659-664.20. Gasparovic ML, Gee GV, Atwood WJ. JCvirus minor capsid proteins Vp2 and Vp3are essential for virus propagation. J Virol.2006;80(21):10858-10861.21. Frisque RJ. Structure and function ofJC virus T’ proteins. J Neurovirol. 2001;7(4):293-297.22. Sugimoto C, Hasegawa M, Kato A, et al.Evolution of human Polyomavirus JC:implications for the population history ofhumans. J Mol Evol. 2002;54(3):285-297.23. Behzad-Behbahani A, Klapper PE, VallelyPJ, et al. Detection of BK virus andJC virus DNA in urine samples from immunocompromised(HIV-infected) andimmunocompetent (HIV-non-infected)patients using polymerase chain reactionand microplate hybridisation. J Clin Virol.2004;29(4):224-229.24. Weber T, Major EO. Progressive multifocalleukoencephalopathy: molecular biology,pathogenesis and clinical impact.Intervirology. 1997;40(2-3):98-111.25. Gheuens S, Pierone G, Peeters P, KoralnikIJ. Progressive multifocal leukoencephalopathyin individuals with minimal oroccult immunosuppression. J Neurol NeurosurgPsychiatry. 2010;81(3):247-254.26. Gillespie SM, Chang Y, Lemp G, et al. Progressivemultifocal leukoencephalopathyin persons infected with human immunodeficiencyvirus, San Francisco, 1981-1989. Ann Neurol. 1991;30(4):597-604.27. Dubois V, Moret H, Lafon ME, et al. Prevalenceof JC virus viraemia in HIV-infectedpatients with or without neurological disorders:a prospective study. J Neurovirol.1998;4(5):539-544.28. Okada Y, Endo S, Takahashi H, et al. Distributionand function of JCV agnoprotein.J Neurovirol. 2001;7(4):302-306.29. Hamilton RS, Gravell M, Major EO. Comparisonof antibody titers determined byhemagglutination inhibition and enzymeimmunoassay for JC virus and BK virus. JClin Microbiol. 2000;38(1):105-109.30. Landry ML, Eid T, Bannykh S, Major E.False negative PCR despite high levelsof JC virus DNA in spinal fluid: implicationsfor diagnostic testing. J Clin Virol.2008;43(2):247-249.31. Garcia De Viedma D, Diaz Infantes M, MirallesP, et al. JC virus load in progressivemultifocal leukoencephalopathy: analysisof the correlation between the viral burdenin cerebrospinal fluid, patient survival,and the volume of neurological lesions.Clin Infect Dis. 2002;34(12):1568-1575.32. Cinque P, Koralnik IJ, Clifford DB. Theevolving face of human immunodeficiencyvirus-related progressive multifocalleukoencephalopathy: defininga consensus terminology. J Neurovirol.2003;9(Suppl 1):88-92.33. Gorelik L, Reid C, Testa M, et al. Progressivemultifocal leukoencephalopathy(PML) development is associated withmutations in JC virus capsid proteinVP1 that change its receptor. J Infect Dis.2011;204(1):103-114.34. Monaco MC, Sabath BF, Durham LC, MajorEO. JC virus multiplication in humanhematopoietic progenitor cells requiresthe NF-1 class D transcription factor. J Virol.2001;75(20):9687-9695.35. Jensen PN, Major EO. A classificationscheme for human polyomavirus JCVvariants based on the nucleotide sequenceof the noncoding regulatory region.J Neurovirol. 2001;7(4):280-287.36. Sabath BF, Major EO. Traffic of JC virusfrom sites of initial infection to thebrain: the path to progressive multifocalleukoencephalopathy. J Infect Dis.2002;186(Suppl 2):S180-S186.37. Myers C, Frisque RJ, Arthur RR. Directisolation and characterization of JC virusfrom urine samples of renal andbone marrow transplant patients. J Virol.1989;63(10):4445-4449.38. Chapagain ML, Nerurkar VR. Human polyomavirusJC (JCV) infection of human Blymphocytes: a possible mechanism forJCV transmigration across the blood-brainbarrier. J Infect Dis. 2010;202(2):184-191.S8 July 2011 • Clinical Reviews of JCV and PML

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