Scientific Report 2003-2004 - Cleveland Clinic Lerner Research ...

Continued from Page 6sources. The principal investigators who received the greatest amount ofnewly awarded NIH grant funding during 2002 were:• D. Geoffrey Vince, Ph.D., Biomedical Engineering, received a $4.3 millioncommittment over five years to pursue improvements in real-time ultrasounddetection and analysis of vulnerable atherosclerotic plaque.• George Muschler, M.D., Orthopaedic Surgery and Biomedical Engineering,received a five-year grant for $4.1 million to investigate the biologyof, and applications for, stem-cell therapy in bone reconstruction.• Stanley Hazen, M.D., Ph.D., Cell Biology, received two R01 grants totaling$3.0 million over five years to investigate the role of oxidation processesin the pathogenesis of two inflammatory diseases–asthma and atherosclerosis.Bruce R. Trapp, Ph.D., recipientof the 2003 CCF ScientificAchievement Award in BasicResearch• Bruce Trapp, Ph.D., Neurosciences, received $2.8 million toexpand upon his contributions in the area of neuron demyelinationand degeneration in multiple sclerosis. Dr. Trapp receivedthe Jacob Javits Award during 2002. This award willprovide an additional three years of funding, for a total of sevenyears of support. The Javits Award is the most prestigious honor bestowedby the National Institute of Neurological Disorders andStroke in support of biomedical research on the brain.The LRI added to its technological base during this past yearas well, using both CCF and NIH support. NIH Shared Equipmentgrants provided $2.8 million for major capital items. These includedthe purchase of a 600 MHz NMR spectrometer and a $1.5 millioncontribution toward a 900 MHz NMR spectrometer that will behoused in the Cleveland Center for Structural Biology. We alsopurchased a BIACORE 3000 instrument for the analysis of kineticand affinity parameters of biomolecule interactions, and a roboticssystem for use in proteomic approaches. In addition, we are in thefinal stages of construction of a new vivarium, started in 2002,which will expand our animal facilities by ~50,000 square feet and isscheduled to be opened in late Fall of 2003. This new space has beensorely needed to meet the growing demands of our investigators for additional mouse facilities.CCF scientists are an integralpart of the new ClevelandCenter for RegenerativeMedicine, a Northeast Ohioconsortium dedicated toadvancing stem-cell-basedtechnologies and therapies.The Center’s researchprogram has been funded by a$19.4 million grant from theState of Ohio to supportinvestigations such as thedevelopment of bone replacementcells from adult stemcells, the work of GeorgeMuschler, M.D., OrthopaedicSurgery and Department ofBiomedical Engineering.New Faculty in the LRIIn 2002, we successfully recruited Peter Cavanagh, Ph.D., from Penn State University to bethe new Chairman of the Department of Biomedical Engineering, our largest and most diverse department.Dr. Cavanagh was a Distinguished Professor of Kinesiology, Biobehavioral Health, Medicine, andOrthopaedics and Rehabilitation at Penn State. He was also the Director of the Penn State UniversityCenter for Locomotion Studies and Research Director of the Penn State Diabetes Foot Clinics. Dr.Cavanagh is actively involved in the American Diabetes Association and has served as national Chair ofthe ADA Council on Foot Care. He has been President of both the American and International Societiesof Biomechanics.Dr. Cavanagh’s research interests are presently focused on the lower extremity complications ofdiabetes and on bone mineral loss during long-term space flight. He has received numerous internationalawards for excellence and contributions to the science of biomechanics. In 1994, he received theBorelli Award, the highest honor awarded by the American Society of Biomechanics. He is a 1987recipient of the International Society of Biomechanics’ highest award, the Muybridge Medal, and haspresented the Wolffe and Dill Lectures to the American College of Sports Medicine. In 2002 he wasgiven the Pecoraro Award by the American Diabetes Association Foot Council.We are currently focused on recruiting individuals to chair the LRI Cell Biology Department,CCF’s Human Genetics/Genomics Institute, and a director for the Taussig Cancer Center. In addition,the CCF Board of Governors has approved the creation of a new Department of Stem Cell Biology andContinued on Page 87