Scientific Report 2003-2004 - Cleveland Clinic Lerner Research ...

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Paul E. DiCorleto, Ph.D.–The Lerner Research Institute Chairman’s OverviewPaul E. DiCorleto, Ph.D.Chairman,Lerner Research InstituteMy first year as Chairman of the Lerner Research Institute (LRI) has been both exciting andextremely positive. It has been a great privilege and honor to succeed George R. Stark, Ph.D., asChairman. Dr. Stark headed the LRI from 1992 until August 2002, a decade that will beviewed as a period of great growth of our institution, both in personnel and facilities. Dr. Starkadvanced the tradition and vision established and fostered by Irvine Page, Merlin Bumpus, and BernadineHealy, whose leadership shaped the Division of Research of the Cleveland Clinic Foundation (CCF) intothe modern, world-class institution that the LRI is today. Dr. Stark remains a very active member of ourfaculty as CCF’s first Distinguished Scientist.During the past year our research portfolio and external support has continued to climb dramaticallyand our number of publications in the highest impact, peer-reviewed journals has increased onceagain. With our growth during the past year, the LRI is now home to over 1,000 employees, including132 principal investigators, 166 junior faculty, 250 postdoctoral fellows, 140 predoctoral and undergraduatestudents, and 350 technologists and support personnel. All are contributing greatly to theresearch mission of CCF.A major event for the LRI and all of CCF in 2002 and 2003 has been the creation and developmentof the Cleveland Clinic Lerner College of Medicine (CCLCM). As discussed in greater detail below,this collaboration with Case Western Reserve University (CWRU) will create an unprecendented andextraordinary opportunity for advancement of both science and patient care and meshes beautifully withCCF’s mission to provide compassionate healthcare of the highest quality in a setting of education andresearch.Growth in our Research MissionThe opportunities to conduct world-class research at the LRI are built upon our success inexternal funding and the continuing internal support from CCF. External grant support continued to riseat double-digit rates. In 2002, NIH multi-year awards increased from 150 to 187--an 18.7% increase.The 2002 NIH award commitment increased by $7.6 million to a total of $55.1 million, 16% more thanthe previous year. Total external funding from all sources exceeded $100 million. CCF researchers wereawarded 47 new and renewed multi-year grants of more than $1 million each from external fundingContinued on Page 7NIH Grant Awards to CCF$60$50Dollars(millions)$40$30$20$10$019861987198819891990199119921993199419951996199719981999200020012002Year6
Continued from Page 6sources. The principal investigators who received the greatest amount ofnewly awarded NIH grant funding during 2002 were:• D. Geoffrey Vince, Ph.D., Biomedical Engineering, received a $4.3 millioncommittment over five years to pursue improvements in real-time ultrasounddetection and analysis of vulnerable atherosclerotic plaque.• George Muschler, M.D., Orthopaedic Surgery and Biomedical Engineering,received a five-year grant for $4.1 million to investigate the biologyof, and applications for, stem-cell therapy in bone reconstruction.• Stanley Hazen, M.D., Ph.D., Cell Biology, received two R01 grants totaling$3.0 million over five years to investigate the role of oxidation processesin the pathogenesis of two inflammatory diseases–asthma and atherosclerosis.Bruce R. Trapp, Ph.D., recipientof the 2003 CCF ScientificAchievement Award in BasicResearch• Bruce Trapp, Ph.D., Neurosciences, received $2.8 million toexpand upon his contributions in the area of neuron demyelinationand degeneration in multiple sclerosis. Dr. Trapp receivedthe Jacob Javits Award during 2002. This award willprovide an additional three years of funding, for a total of sevenyears of support. The Javits Award is the most prestigious honor bestowedby the National Institute of Neurological Disorders andStroke in support of biomedical research on the brain.The LRI added to its technological base during this past yearas well, using both CCF and NIH support. NIH Shared Equipmentgrants provided $2.8 million for major capital items. These includedthe purchase of a 600 MHz NMR spectrometer and a $1.5 millioncontribution toward a 900 MHz NMR spectrometer that will behoused in the Cleveland Center for Structural Biology. We alsopurchased a BIACORE 3000 instrument for the analysis of kineticand affinity parameters of biomolecule interactions, and a roboticssystem for use in proteomic approaches. In addition, we are in thefinal stages of construction of a new vivarium, started in 2002,which will expand our animal facilities by ~50,000 square feet and isscheduled to be opened in late Fall of 2003. This new space has beensorely needed to meet the growing demands of our investigators for additional mouse facilities.CCF scientists are an integralpart of the new ClevelandCenter for RegenerativeMedicine, a Northeast Ohioconsortium dedicated toadvancing stem-cell-basedtechnologies and therapies.The Center’s researchprogram has been funded by a$19.4 million grant from theState of Ohio to supportinvestigations such as thedevelopment of bone replacementcells from adult stemcells, the work of GeorgeMuschler, M.D., OrthopaedicSurgery and Department ofBiomedical Engineering.New Faculty in the LRIIn 2002, we successfully recruited Peter Cavanagh, Ph.D., from Penn State University to bethe new Chairman of the Department of Biomedical Engineering, our largest and most diverse department.Dr. Cavanagh was a Distinguished Professor of Kinesiology, Biobehavioral Health, Medicine, andOrthopaedics and Rehabilitation at Penn State. He was also the Director of the Penn State UniversityCenter for Locomotion Studies and Research Director of the Penn State Diabetes Foot Clinics. Dr.Cavanagh is actively involved in the American Diabetes Association and has served as national Chair ofthe ADA Council on Foot Care. He has been President of both the American and International Societiesof Biomechanics.Dr. Cavanagh’s research interests are presently focused on the lower extremity complications ofdiabetes and on bone mineral loss during long-term space flight. He has received numerous internationalawards for excellence and contributions to the science of biomechanics. In 1994, he received theBorelli Award, the highest honor awarded by the American Society of Biomechanics. He is a 1987recipient of the International Society of Biomechanics’ highest award, the Muybridge Medal, and haspresented the Wolffe and Dill Lectures to the American College of Sports Medicine. In 2002 he wasgiven the Pecoraro Award by the American Diabetes Association Foot Council.We are currently focused on recruiting individuals to chair the LRI Cell Biology Department,CCF’s Human Genetics/Genomics Institute, and a director for the Taussig Cancer Center. In addition,the CCF Board of Governors has approved the creation of a new Department of Stem Cell Biology andContinued on Page 87
Page 7: From the Chairman, Board of Governo
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Page 13 and 14: BiomedicalEngineering
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THE HESTONLABORATORYSTAFF SCIENTIST
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The Department of Cancer BiologyIde
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THE SIZEMORELABORATORYRESEARCH FELL
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THE WILLIAMSLABORATORYPROJECT SCIEN
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THE YI LABORATORYPOSTDOCTORAL FELLO
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DEPARTMENT OFCELL BIOLOGYINTERIM CH
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The Department of Cell BiologyRole
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THE CHISOLMLABORATORYRESEARCH ASSOC
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THE DRISCOLLLABORATORYPOSTDOCTORAL
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THE HAZENLABORATORYRESEARCH ASSOCIA
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The Department of Cell BiologyHyper
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The Department of Cell BiologyRole
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THE J. SMITHLABORATORYTECHNOLOGISTG
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THE WEIMBSLABORATORYPROJECT SCIENTI
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The Department of Cell BiologyCell
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DEPARTMENTOF IMMUNOLOGYCHAIRMANThom
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THE ARONICALABORATORYSENIOR RESEARC
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THE HAMILTONLABORATORYPROJECT SCIEN
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THE M. SIEMIONOWLABORATORYRESEARCH
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The Department of ImmunologyHyaluro
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The Department of ImmunologyImmunol
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DEPARTMENT OFMOLECULAR BIOLOGYCHAIR
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THE GUDKOVLABORATORYPROJECT SCIENTI
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THE HARTERLABORATORYPOSTDOCTORAL FE
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THE PADGETTLABORATORYPROJECT SCIENT
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THE G. SENLABORATORYPROJECT SCIENTI
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THE STARKLABORATORYPROJECT SCIENTIS
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THE PELLETTLABORATORYRESEARCH ASSOC
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The Department of Molecular Biology
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DEPARTMENT OFMOLECULARCARDIOLOGYThe
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THE BERKNERLABORATORYPOSTDOCTORAL F
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THE J. FOXLABORATORYPROJECT SCIENTI
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THE KARNIKLABORATORYRESEARCH ASSOCI
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THE PLOWLABORATORYCOLLABORATORSTati
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The Department of Molecular Cardiol
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DEPARTMENT OFNEUROSCIENCESCHAIRMANB
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THE KOMUROLABORATORYCOLLABORATORSAr
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THE MACKLINLABORATORYPROJECT STAFFT
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THE NAJMLABORATORYCOLLABORATORSWill
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THE PERINLABORATORYPOSTDOCTORAL FEL
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THE RANSOHOFFLABORATORYThe Departme
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THE STAUGAITISLABORATORYCOLLABORATO
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THE TRAPPLABORATORYINVESTIGATORSAns
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CENTER FORANESTHESIOLOGYRESEARCHDIR
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Role of Receptors and Ion Channels
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CENTER FORCEREBROVASCULASRESEARCHCe
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THE JANIGROLABORATORYPROJECT SCIENT
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THE HOLLYFIELDLABORATORYPROJECT SCI
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THE ANAND-APTELABORATORYPOSTDOCTORA
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THE HAGSTROMLABORATORYSENIOR TECHNO
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THE V. PEREZLABORATORYTECHNOLOGISTA
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Continued from Page 167active train
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J.J. JACOBS CENTERFOR THROMBOSIS AN
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THE BORDENLABORATORYRESEARCH ASSOCI
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CLEVELAND CENTERFOR STRUCTURALBIOLO
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THE QIN LABORATORYPOSTDOCTORAL FELL
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The view from the skyway between th
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OFFICE OFSPONSORED RESEARCHEXECUTIV
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BIOLOGICAL RESOURCES UNITThe Clevel
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IMAGING COREIMAGING COREDIRECTORJud
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HYBRIDOMA COREHYBRIDOMA COREDIRECTO
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LERNER RESEARCHINSTITUTECOMPUTING S
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ELECTRONICS COREELECTRONICS COREMAN
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MEDICAL SCIENTIFIC COMMUNICATIONSME
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Keyword IndexACESen, I. 129Acoustic
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Keyword IndexMacrophagesHamilton 92
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Illustrations LegendsBIOMEDICAL ENG
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Continued from Page 199SCIENTIFIC S
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