Scientific Report 2003-2004 - Cleveland Clinic Lerner Research ...

RESEARCH CORE SERVICESThe Research Core Services provide investigators at the Lerner Research Institute (LRI) withaccess to technology and instrumentation that is too costly, complex, or otherwise inaccessible toindividual laboratories. The cores rely on feedback and direction from the research staff and arecommitted to enhancing the research performed by all LRI scientists and clinician-scientists of theCleveland Clinic as a whole.Demand for and usage of the Core Services continues to increase, especially for the GeneExpression Core, the Hybridoma Core, the Flow Cytometry Core, and the Central Cell Services Core,and requisite expansions are under way to meet the rising demand.A significant change in the Gene Expression Core involves the beginning of a new interinstitutionalcollaboration: The Affymetrix section of the Gene Expression Core has teamed up withthe Affymetrix Core of Case Western Reserve University (CWRU) to provided expanded capacity andservices to all Cleveland investigators. Drs. Martina Veigl and Patrick Leahy of the CWRU AffymetrixFacility have presented talks for investigators at CCF and, together with Dr. Colmenares, are planning onoffering a course on analysis of microarray data at CCF.Expanded software options for analysis of microarray data are provided both at CCF and throughthe CWRU Affymetrix service. These include GeneSpring, Spotfire, and Microarray Suite. TheAffymetrix Micro DB and Data Mining Tool are also available on computers at both CWRU and CCF.Expansion of the Biological ResourcesUnit (BRU) Core continues under the abledirection of Dr. Stan Dannemiller. The BRUwill move into its new vivarium in the fall of2003. This facility will supplement existinganimal housing and allow for expansion ofboth the animal census and of servicesprovided by the BRU for CCF investigator.As a consequence of the newvivarium’s construction, the Transgenic andKnockout Mouse Core operations have beentemporarily halted. The Core expects toreopen in its new quarters within the newvivarium building. In the interim, in anothernew interaction between CCF and CWRU,transgenic and knockout mouse services areavailable through core services at CWRU.The Imaging Core has recently added aLeica microdissection microscope.All the cores continue to explore newdirections and offer expanded services, whichare described in more detail on the followingpages.RESEARCH CORESERVICESDIRECTORClemencia Colmenares, Ph.D.COORDINATORJeanne InemanMission Statement of theResearch Core Services:To provide high qualityservices, expertise,education and resourcesin support of research atthe Cleveland ClinicFoundationClemencia Colmenares, Ph.D.Director, Research Core ServicesWebsite: http://info.lerner.ccf.org/services/181