Scientific Report 2003-2004 - Cleveland Clinic Lerner Research ...

THE STAUGAITISLABORATORYCOLLABORATORSGene Barnett, M.D. 1Richard Ransohoff, M.D. 2Olga Tchernova, Ph.D. 1Bruce D. Trapp, Ph.D. 2Raymond Tubbs, D.O. 31Brain Tumor Institute, CCF2Dept. of Neurolosciences, CCF3Dept. of Clinical Pathology,CCFMy research focuses on the molecularcharacterization of human neurologicaldisease. This approach includescharacterization of specific candidate targetmolecules identified through basic research onanimal models, screening of molecules identifiedthrough large-scale analysis gene expression, anddevelopment of clinical laboratory tests.Through my joint appointments in the Departmentsof Neurosciences and Anatomic Pathology,I facilitate the close lines of communicationsThe Department of NeurosciencesHuman Neurological SpecimenResearch Leads to Clinical TestsUsed in Treatment Planningamong clinical, laboratory, and basic sciencedepartments that are essential to achieve correctdiagnosis and optimal utilization of excess tissuespecimens for research. My specific activitiesinclude genotypic and phenotypic analysis ofgliomas for use as clinical tests in treatmentplanning. In addition, I work closely with theMultiple Sclerosis research group in the Departmentof Neurosciences to facilitate acquisitionand analysis of human surgical and postmortemspecimens.Susan M. Staugaitis, M.D., Ph.D.Pedraza, L., Fidler, L, Staugaitis, S.M., and D.R. Colman (1997) The active transport of myelin basic proteininto the nucleus suggests a regulatory role in myelination. Neuron 18:579-589.Shoshan, Y., Nishiyama, A., Mork, S., Barnett, G.H., Cowell, J.K., Trapp, B.D., and S.M. Staugaitis (1999)Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis ofbrain tumors. Proc. Natl. Acad. Sci. USA 96:10361-10366.Staugaitis, S.M., Zerlin, M., Hawkes, R., Levine, J.M., and J.E. Goldman (2001) Aldolase C/zebrin II expressionin the neonatal rat forebrain reveals cellular heterogeneity within the subventricular zone and earlyastrocyte differentiation. J. Neurosci. 21:6195-6205.Trebst, C., Staugaitis, S.M., Kivisakk, P., Mahad, D., Cathcart, M.K., Tucky, B., Wei, T., Rani, M.R., Horuk,R., Aldape, K.D., Pardo, C.A., Lucchinetti, C.F., Lassmann, H., and R.M. Ransohoff (2003) CCchemokine receptor 8 in the central nervous system is associated with phagocytic macrophages. Am. J.Pathol. 162:427-438.Chahlavi, A., Kanner, A., Peereboom, D., Staugaitis, S.M., Elson, P., and G. Barnett (2003) Impact ofchromosome 1p status in response of oligodendroglioma to temozolomide: preliminary results.Neuro-Oncology 61:267-73.148