Scientific Report 2003-2004 - Cleveland Clinic Lerner Research ...

DEPARTMENT OFNEUROSCIENCESCHAIRMANBruce D. Trapp, Ph.D.STAFFWendy Macklin, Ph.D.ASSOCIATE STAFFMark Perin, Ph.D.ASSISTANT STAFFKeiko Hirose, M.D.Hitoshi Komuro, Ph.D.Masaru Nakamoto, M.D., Ph.D.Susan Staugaitis, M.D., Ph.D.STAFF SCIENTISTClara Pelfrey, Ph.D.PROJECT SCIENTISTSTatyana Gudz, Ph.D.Yulong Han, Ph.D.Grahame Kidd, Ph.D.Sandhya Rani, Ph.D.Jerome Wujek, Ph.D.Xinghua Yin, M.D.Neuroscientists Examine BrainDevelopment, Neuronal Function,and Pathogenesis of Human DiseaseThe Department of Neurosciences, foundedin 1994, is chaired by Dr. Bruce Trapp andcomprises a core of internationallyrecognized scientists who investigate the cellularand molecular biology of brain development andneuronal and glial function. In collaboration withresearch programs in the Clinic’s Departments ofNeurology and Neurological Surgery, staffscientists also participate in clinically relevantresearch in the areas of myelin disease,neurodegeneration, neuro-oncology, epilepsy andcerebrovascular disease.Glial Development and Myelin FormationThe glial program includes Drs. Trapp,Wendy Macklin, Susan Staugaitis, RichardRansohoff and Richard Rudick. Drs. Trapp andMacklin investigate basic questions related to thecellular and molecular biology of glial developmentand myelin formation. Dr. Susan Staugaitisis a board-certified neuropathologist who hasjoint appointments in the Departments ofNeurosciences and of Pathology and LaboratoryThe Department of NeurosciencesMedicine. Dr. Staugaitis investigates glialprogenitor cells as the source of glial tumors inthe central nervous system (CNS). Dr. Trapp alsoinvestigates mechanisms responsible for destructionof myelin and axons in individuals withmultiple sclerosis (MS), and Dr. Macklininvestigates the glial response in animal models ofhypoxia. The glial research program has close tieswith physicians in the Cleveland Clinic’s MellenCenter for Multiple Sclerosis Treatment andResearch, which houses one of the largest clinicalMS programs in the world.Drs. Ransohoff and Rudick hold jointappointments in the Departments of Neurologyand Neurosciences. Dr. Ransohoff ’s researchfocuses on the regulation and function ofchemokines as they pertain to the pathogenesis ofdemyelinating diseases. Dr. Rudick directs clinicaltrials in MS therapeutics and is interested inoutcome measures and surrogate markers forContinued on Page 135RESEARCH ASSOCIATESAna Flores, Ph.D.DeRen Huang, M.D.JOINT APPOINTMENTSManjunatha Bhat, Ph.D.Nicholas Boulis, M.D.Mark Luciano, M.D.Marc Mayberg, M.D.Erwin Montgomery, M.D.Erik Pioro, M.D., Ph.D.Richard Ransohoff, M.D.Richard Rudick, M.D.Thyagarajan Subramanian, M.D.ADJUNCT STAFFTomasz Kordula, Ph.D. 1Robert H. Miller, Ph.D. 21Dept. of Biological, Geological,and EnvironmentalSciences, Cleveland StateUniv., Cleveland, OH2Dept. of Neurosciences, CaseWestern Reserve Univ.,Cleveland, OHBruce D. Trapp, Ph.D.Dept. website: http://www.lerner.ccf.org/neurosci/134