Scientific Report 2003-2004 - Cleveland Clinic Lerner Research ...

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The Department of Molecular CardiologyMolecular Cardiology Project and Staff Scientistswith Independent FundingOlga Stenina, Ph.D.,I am interested in mechanisms of initiation of atherosclerotic lesions,and currently I am studying the role of thrombospondins in theseprocesses. Thrombospondins are regulating the interaction ofvascular cells with cellular matrix. These proteins have beenassociated with premature familial coronary artery disease at thegenetic level1. Our investigation of functional consequences ofproatherogenic single nucleotide polymorphisms in thrombospondingenes revealed that decreased adhesion and proliferation of endothelialcells in presence of mutant thrombospondin-4 may be a cause foraccelerated development of atherosclerosis. The expression ofthrombospondin-1, a potent anti-angiogenic and proatherogenic agent,increases in vascular wall in diabetes, a condition strongly predisposingto atherosclerosis. This protein may represent an important linkbetween diabetes, accelerated atherogenesis and increased restenosis.Tatiana Ugarova, Ph.D.Our laboratory studies the structure of integrins and their functionsin adhesion and migration of blood cells. The major object is integrinα Mβ 2(Mac-1, CD11b/CD18), a multi-ligand receptor which plays acentral role in the inflammatory response and host defense. Weexamine the mechanism which allows α Mβ 2to exhibit broad ligandspecificity and explore the biological value of its ligand promiscuity.We are testing the hypothesis that translocation of α Mβ 2to thesurface of neutrophils from internal pools and its capacity to bindnumerous extracellular matrix proteins control an overall process ofneutrophil migration. Another project examines the molecular basisfor binding of fibrinogen by platelet integrins in thrombus formationand remodeling.132
Neurosciences
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BiomedicalEngineering
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BIOLOGICAL RESOURCES UNITThe Clevel
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IMAGING COREIMAGING COREDIRECTORJud
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LERNER RESEARCHINSTITUTECOMPUTING S
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MEDICAL SCIENTIFIC COMMUNICATIONSME
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Keyword IndexACESen, I. 129Acoustic
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Keyword IndexMacrophagesHamilton 92
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Illustrations LegendsBIOMEDICAL ENG
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