Scientific Report 2003-2004 - Cleveland Clinic Lerner Research ...
Scientific Report 2003-2004 - Cleveland Clinic Lerner Research ... Scientific Report 2003-2004 - Cleveland Clinic Lerner Research ...
The Department of Molecular BiologyGlobal effect of tumorsuppressor gene p53 onradiation response ofmammalian tissues. Wild type(left) and p53-deficient (right) micewere treated with 10Gy of total bodygamma radiation and cell proliferationin tissues was determined in situ by14C-thymidine incorporation followedby autoradiography of whole-bodysections. While p53-wild type animalsshowed dramatic reduction in DNAreplication in all tissues, p53-nullmice maintained the same rate ofDNA synthesis as non-irradiatedanimals. This result reflects the keyrole of p53 in genotoxic stressresponse in mammalian organism.(From Komarova et al., 2000.Oncogene 19, 3791-3798).116
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The Department of Molecular BiologyGlobal effect of tumorsuppressor gene p53 onradiation response ofmammalian tissues. Wild type(left) and p53-deficient (right) micewere treated with 10Gy of total bodygamma radiation and cell proliferationin tissues was determined in situ by14C-thymidine incorporation followedby autoradiography of whole-bodysections. While p53-wild type animalsshowed dramatic reduction in DNAreplication in all tissues, p53-nullmice maintained the same rate ofDNA synthesis as non-irradiatedanimals. This result reflects the keyrole of p53 in genotoxic stressresponse in mammalian organism.(From Komarova et al., 2000.Oncogene 19, 3791-3798).116
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