MILITARY PHARMACY AND MEDICINE

© Military Pharmacy and Medicine • 2012 • 4 • 31 – 32affect the stability of its physicochemical parametersupon storage.Figure 5 presents an example curve of ointmentwater loss.Justyna Kołodziejska at al.: Cholesterol oxyethyleneation products as …2152.8 c.u. In case of the ointment with unmodifiedformula (M-0), the value was 1895.5 c.u.(Table 4). As shown by the calculations, the testedointments would be characterized by comparablechanges in viscosity parameters during applicationon the tissue affected by inflammation. Thediffusibility of ketoprofen lysinate would be atsimilar levels throughout the contact with theapplication site, as follows from th e Einstein-Smoluchowski equation (D=kT/6πrη).Results of determination of the kinetics ofthe release of lysinate from the ointmentFigure 5: Kinetics of water loss for the M-Ch-10 Ca ointment.Table 4: Parameters of the regression equation of the typey=ax+b describing the kinetics of the loss ofwater from the ointmentOintmentRegression equationcoefficientsabCorrelationcoefficientrSurfacearea [c.u.]M-0 0.1653 0.4036 0.9916 1895.5Figure 6 presents an example of the relationshipbetween the quantity of the released ketoprofenlysinate (in mg per cm2 of the dialysis membrane)as a function of the square root of time.The obtained relationships were described bycorrelation equations of the types y=ax+b andlg(y)=a·lgx+b (a logarithmic form of the exponentialM-Ch-10 Na 0.1721 0.4951 0.9912 1983.6M-Ch-20 Na 0.1560 0.4693 0.9871 1800.8M-Ch-30 Na 0.1875 0.4776 0.9945 2152.8M-Ch-40 Na 0.1760 0.4549 0.9921 2021.6M-Ch-10 Ca 0.1744 0.4520 0.9927 2003.4The relationship between the loss in the massof the tested ointments [%] and time [min.] wasdescribed at the significance level ofp=0.05 by a regression equation ofthe type y=ax+b. Parameters a andbe were used to calculate the surfaceareas P under the water loss curves,expressed in conventional units [c.u.],using an integration method. Theobtained values are listed in Table 4.It was shown that introduction of cholesteroloxyethyleneation productsinto the ointment formula did not significantlyaffect the loss of water fromthe products. Surface areas under thecurves of the loss of water from theointment containing different cholesterolderivatives ranged from 1800.8 toOintmentM-0M-Ch-10NaM-Ch-20NaM-Ch-30NaM-Ch-40NaM-Ch-10Cahttp://military.isl-journals.comFigure 6: Kinetics of the release of ketoprofen lysinate from theM-Ch-30 Na ointment.Table 5: Regression equations describing the kinetics ofthe release of ketoprofen lysinate from modelointmentsRegressionequationtypey=ax+blg(y)=a·lgx+by=ax+blg(y)=a·lgx+by=ax+blg(y)=a·lgx+by=ax+blg(y)=a·lgx+by=ax+blg(y)=a·lgx+by=ax+blg(y)=a·lgx+bRegression equationcoefficientsab4.1365·10-3 -2,0335·10-20.6435 -1.84175.160·10-31.02525.1299·10-31.63525.4611·10-31.18116.0644·10-31.57585.5206·10-31.4582-0.0451·10-2-2.3003-2.2820·10-2-3.2015-1.0226·10-2-2.5368-2.7472·10-2-3.0646-2.3623·10-2-2.9553Correlationcoefficientr0.97310.96510.97460.96680.99400.99710.99910.99980.98810.99750.98460.9909Surfacearea[c.u.]0.40440.90880.53190.74420.62250.974631