Research Report 2010 - MDC

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Surgical OncologyPeter M. Schlag.............................................................................................................................................................................. 96Cancer Genetics and Cellular Stress Responses in Pathogenesis andTreatment of Lymphatic MalignanciesClemens A. Schmitt ..................................................................................................................................................................... 100Mechanisms of Protein Quality ControlThomas Sommer .......................................................................................................................................................................... 102Nuclear Signaling and Chromosomal DomainsHarald Saumweber...................................................................................................................................................................... 106Structural and Functional GenomicsMacromolecular Structure and InteractionUdo Heinemann ........................................................................................................................................................................... 108Structure and Mechanism of Membrane-remodeling G-proteinsOliver Daumke ............................................................................................................................................................................... 112Bioethics and Science CommunicationChristof Tannert ............................................................................................................................................................................ 114Tumor ImmunologyDifferentiation and Growth Control in Lymphocyte Development and ImmunopathogenesisMartin Lipp...................................................................................................................................................................................... 116Regulatory Mechanisms of Lymphocyte Trafficking in Homeostasis and ImmunopathogenesisUta E. Höpken (Delbrück Fellow) ........................................................................................................................................... 120Molecular Immunology and Gene TherapyThomas Blankenstein ................................................................................................................................................................. 122Molecular Cell Biology and Gene TherapyWolfgang Uckert........................................................................................................................................................................... 124Biology and Targeted Therapy of LymphomaBernd Dörken ................................................................................................................................................................................. 126Molecular ImmunotherapyAntonio Pezzutto .......................................................................................................................................................................... 130Clinical and Molecular OncologyPeter Daniel..................................................................................................................................................................................... 132Cellular Immunology of Autoimmune Reactions – Controlling the Balancebetween Effector and Suppressor T CellsKirsten FalkOlaf Rötzschke ............................................................................................................................................................................... 134Experimental PharmacologyIduna Fichtner................................................................................................................................................................................ 136IV Content
Function and Dysfunction of the Nervous SystemFunktion und Dysfunktion des Nervensystems .............................................. 141Coordinator: Carmen BirchmeierSignaling Pathways and Mechanisms in the Nervous SystemDevelopmental Biology/Signal TransductionCarmen Birchmeier...................................................................................................................................................................... 150Physiology and Pathology of Ion TransportThomas Jentsch ............................................................................................................................................................................ 154Neuronal ConnectivityFritz G. Rathjen .............................................................................................................................................................................. 158Molecular Physiology of Somatic SensationGary R. Lewin .................................................................................................................................................................................. 162Molecular Neurobiology of Cell-surface Channels and ReceptorsInes Ibañez-Tallon......................................................................................................................................................................... 166RNA Editing and Hyperexcitability DisordersJochen C. Meier.............................................................................................................................................................................. 168Signaling and Transport ProcessesBjörn Christian Schroeder ........................................................................................................................................................ 170Sensory NeurobiologyJan Siemens .................................................................................................................................................................................... 172Neural Circuits and BehaviorJames Poulet ................................................................................................................................................................................. 174Imaging of the Living BrainMolecular NeurologyFrauke Zipp ........................................................................................................................................................................................ 176Pathophysiological Mechanisms of Neurological and Psychiatric DisordersCellular NeurosciencesHelmut Kettenmann................................................................................................................................................................... 178Proteomics and Molecular Mechanisms of Neurodegenerative DisordersErich Wanker................................................................................................................................................................................... 182Aging-related Protein Misfolding and Detoxification MechanismsJan Bieschke (Delbrück Fellow)............................................................................................................................................... 186Content V
Page 1: Research Report 2010MAX DELBRÜCK C
Page 4 and 5: ContentInhaltContentInhalt.........
Page 11 and 12: at the MDC. The role of the institu
Page 13 and 14: in discovering genes that contribut
Page 16 and 17: The ECRC offers research space and
Page 18 and 19: etween disciplines such as biology,
Page 20 and 21: approaches from bioinformatics/syst
Page 23 and 24: von Humboldt Foundation (AvH). The
Page 25: organization to a larger, multi-fac
Page 28 and 29: Cardiovascular and Metabolic Diseas
Page 30 and 31: electrical signals. More recent wor
Page 32 and 33: Basic Cardiovascular FunctionStruct
Page 34 and 35: Figure 2: SORLA and sortilin in neu
Page 36 and 37: Annette Hammes(Delbrück Fellow)Str
Page 38 and 39: Ingo L. MoranoStructure of the Grou
Page 40 and 41: Figure 3. Membrane resealing assay
Page 42 and 43: Michael GotthardtStructure of the G
Page 44 and 45: Structure of the GroupSalim Seyfrie
Page 46 and 47: Structure of the GroupFerdinand le
Page 48 and 49: Francesca M. SpagnoliStructure of t
Page 50 and 51: Structure of the GroupKai M. Schmid
Page 52 and 53: Genetics and Pathophysiology of Car
Page 54 and 55: Figure 2. Planariato experimentally
Page 56 and 57:
Norbert HübnerStructure of the Gro
Page 58 and 59:
Structure of the GroupGroup LeaderF
Page 60 and 61:
Figure 2. Omega-3 fatty acids prote
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Structure of the GroupDominik N. M
Page 64 and 65:
Rainer DietzStructure of the GroupG
Page 66 and 67:
Figure 2. Cardiac-restricted ablati
Page 68 and 69:
Ludwig ThierfelderStructure of the
Page 70 and 71:
standing of the molecular and cellu
Page 72 and 73:
Structure of the GroupThoralf Niend
Page 74 and 75:
Michael BaderStructure of the Group
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Natriuretic peptide systemJens Butt
Page 78 and 79:
Structure of the GroupZsuzsanna Izs
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Young-Ae LeeStructure of the GroupG
Page 82 and 83:
Structure of the GroupMatthias Selb
Page 84 and 85:
Matthew PoyStructure of the GroupGr
Page 86 and 87:
Jana WolfStructure of the GroupGrou
Page 88 and 89:
Structure of the GroupGroup LeaderD
Page 91 and 92:
Cancer Research ProgramKrebsforschu
Page 93 and 94:
are responsible for the emergence o
Page 95 and 96:
tral component of the canonical Wnt
Page 97 and 98:
lead to an aberrant constitutive ac
Page 99 and 100:
How Notch- and TGFβ signaling casc
Page 101 and 102:
tures of the chronic phase in human
Page 103 and 104:
oped a new safeguard that is based
Page 105 and 106:
Graduate StudentsSeda Cöl ArslanCa
Page 107 and 108:
investigation, as is the cause of c
Page 109 and 110:
Graduate StudentsÖzlem Akilli Özt
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onment, the (cancer) stem cell nich
Page 113 and 114:
The pluripotent state of murine and
Page 115 and 116:
In the morula of the early mouse em
Page 117 and 118:
Graduate StudentsRami Hamscho*Qingb
Page 119 and 120:
esis and granulopoiesis. We showed
Page 121 and 122:
URE ∆/∆ mice regularly develope
Page 123 and 124:
PD Dr. Wolfgang Walther (GroupLeade
Page 125 and 126:
For the delivery of naked DNA into
Page 127 and 128:
ACBDMyc and FoxO transcription fact
Page 129 and 130:
Graduate StudentsKatrin BagolaHolge
Page 131 and 132:
Heinemann, we could also identify t
Page 133 and 134:
Above: Tip of chromosom3L showing t
Page 135 and 136:
Graduate StudentsSarbani Bhattachar
Page 137 and 138:
vesicle transport to the Golgi. Our
Page 139 and 140:
acbFigure 1a: EHD2 is tubulatingpho
Page 141 and 142:
KnowledgeProbabilitiesknownPossible
Page 143 and 144:
Graduate and undergraduatestudentsU
Page 145 and 146:
successive oncogenic mutations. We
Page 147 and 148:
CXCR5 drives the development of ect
Page 149 and 150:
Graduate and undergraduatestudentsW
Page 151 and 152:
Graduate andUndergraduate StudentsM
Page 153 and 154:
Angela MensenStefanie WittstockBjö
Page 155 and 156:
deficient mice, both major effector
Page 157 and 158:
ant of CD3 delta coding for a 45-me
Page 159 and 160:
Robert KudernatschLi-Min LiuAna Mil
Page 161 and 162:
Sebastian GüntherTechnical Assista
Page 163 and 164:
Graduate StudentsJana RolffAnnika W
Page 165:
with murine hepatocytes showed morp
Page 168 and 169:
Function and Dysfunction of the Ner
Page 170 and 171:
The Neuroscience Department also es
Page 172 and 173:
the coming years, Björn Schröder
Page 174 and 175:
mice. Further analysis of the funct
Page 176 and 177:
Signaling Pathways and Mechanisms i
Page 178 and 179:
Control Olig3 -/-ABFigure 2. Geneti
Page 180 and 181:
Thomas J. JentschStructure of the G
Page 182 and 183:
Figure 2. Cellular model for ionic
Page 184 and 185:
Structure of the GroupGroup LeaderF
Page 186 and 187:
paired-pulse facilitation, less dep
Page 188 and 189:
Gary R. LewinStructure of the Group
Page 190 and 191:
Model summarizing the three waves o
Page 192 and 193:
Structure of the GroupInes Ibañez-
Page 194 and 195:
Jochen C. MeierStructure of the Gro
Page 196 and 197:
Björn Christian SchroederStructure
Page 198 and 199:
Structure of the GroupJan Siemens(S
Page 200 and 201:
Structure of the GroupGroup LeaderD
Page 202 and 203:
Imaging of the Living BrainStructur
Page 204 and 205:
Pathophysiological Mechanisms of Ne
Page 206 and 207:
Figure 2. Iba1 positive microglia c
Page 208 and 209:
Erich E. WankerStructure of the Gro
Page 210 and 211:
Scientific-Technical StaffAnja Frit
Page 212 and 213:
Structure of the GroupJan Bieschke(
Page 215 and 216:
Berlin Institute of Medical Systems
Page 217 and 218:
etes, metabolic diseases and neurod
Page 219 and 220:
A number of MDC investigators have
Page 221 and 222:
Technical AssistantsClaudia Langnic
Page 223 and 224:
has become a standardized data flow
Page 225:
Phylogeny of cellulase genes from P
Page 228 and 229:
Experimental and Clinical Research
Page 230 and 231:
his patients, and a basic research
Page 232 and 233:
The ultrahigh field MR facility was
Page 234 and 235:
Structure of the GroupSimone Spuler
Page 236 and 237:
Ralph KettritzStructure of the Grou
Page 238 and 239:
Structure of the GroupJeanette Schu
Page 240 and 241:
Maik GollaschStructure of the Group
Page 243 and 244:
Technology PlatformsComputational B
Page 245 and 246:
projects/ard/] to detect repeats li
Page 247 and 248:
Simulation of line-scan images of C
Page 249 and 250:
Development of an MRM method for qu
Page 251 and 252:
mobility or turnover of the underly
Page 253 and 254:
Left: Inside view of a FACSAria2 (f
Page 255 and 256:
Examples fort the use of EM methods
Page 257:
Oviducts lined up in pre-implantati
Page 260 and 261:
Academic Appointments 2008-2009Beru
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Buch which is part of the Excellenc
Page 264 and 265:
“Bioinformatics in Quantitative B
Page 266 and 267:
Delbrück FellowsDelbrück-Stipendi
Page 268 and 269:
Yinth Andrea Bernal-Sierra, a PhD s
Page 270 and 271:
Congresses and Scientific MeetingsK
Page 272 and 273:
SeminarsSeminare2008Speaker Institu
Page 274 and 275:
Speaker Institute TitleKiyoshi Mori
Page 276 and 277:
2009Speaker Institute TitleDavid G.
Page 278 and 279:
Speaker Institute TitleJuri Rappsil
Page 280 and 281:
The Helmholtz AssociationDie Helmho
Page 282 and 283:
The Berlin-Buch CampusDer Campus Be
Page 284:
the MDC, the existing collaboration
Page 287 and 288:
Prof. Dr. Gary R. LewinMDC Berlin-B
Page 289 and 290:
Prof. Dr. Renato ParoCenter of Bios
Page 291 and 292:
Staff CouncilThe Staff Council is i
Page 293 and 294:
Type of Financing/Art der Finanzier
Page 295 and 296:
Research Projects 2008-2009Forschun
Page 297 and 298:
CIC-5 Regulation und Endocytose am
Page 299 and 300:
MDCMAX-DELBRÜCK-CENTRUMFÜR MOLEKU
Page 301 and 302:
Index 275Bröske, A. . . . . . . .
Page 303 and 304:
Index 277Gross, V. . . . . . . . .
Page 305 and 306:
Index 279Kur, E. . . . . . . . . .
Page 307 and 308:
Index 281Piano, F. . . . . . . . .
Page 309 and 310:
Index 283Smink, J. . . . . . . . .
Page 312 and 313:
Campus MapCampusplanRobert-Rössle-
Page 314:
How to find your way to the MDCDer
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Research Report 2010 - MDC

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