CHEM 4315/6315: Organic Medicinal Chemistry - The University of ...

CHEM 4315/6315: Organic Medicinal ChemistryInstructor: Abby L. Parrill Office: SM 407 Phone: 678-2638 email: aparrill@memphis.eduSchedule: Tuesdays and Thursdays 9:40 – 11:05am Office Hrs T: 8:30-9:30am, R: 11:30-12:30pmTextbook: The Organic Chemistry of Drug Design and Drug Action, second edition, Richard B. Silverman(Suggested) Textbook of Drug Design and Discovery, Third Edition Edited by Povl Krogsgaard-Larsen,Tommy Liljefors and Ulf Madsen.Content:Grading:This course focuses on medicinal chemistry and the underlying principles from organic chemistry.Topics to be covered include drug discovery, lead modification, drug-receptor interactions,enzymes, DNA structure and drug interactions, and drug metabolism. A passing (C) grade inCHEM3312 is a PREREQUISITE for this course.Grades will be based on application of methods and principles discussed to individual projects,unannounced quizzes, homework, class participation (both homework and class participation)included with quizzes for grading purposes) and examinations. The projects will be developedaccording to the following schedule (more details on handout).Project Development Date Expected PointsBrief description of a disease, possible biomolecular targets, andcurrently known lead compounds/clinical agentsRevised Part I, computational methods, results and discussionRevised Part II, synthetic plans, expected problems, and possiblesolutionsFinal Paper (Chem 4315 students: written only, 55 points)(Chem 6315 students: written, 35 points, oral, 20 points)2/10 (for review)2/15 (for grading)3/17 (for review)3/22 (for grading)4/12 (for review)4/14 (for grading)4/26 (for review)4/29 (for grading)Examinations Date PointsPreparation Test (best of two administrations) Jan. 18, Feb. 3 40Midterm I (replaces quizzes to date if higher, or quiz average March 3 40scaled to 20 and midterm I scaled to 20 if not)Midterm II (replaces quizzes since midterm I if higher, or quiz April 21 40average scaled to 20 and midterm II scaled to 20 if not)Final May 3 rd , 10:30am 80Course Total: 300Grading scale (five points at either end of range used for +/-):270-300: A - /A/A + 250-269: B - /B/B + 230-249: C - /C/C + 210-229: D/D +Other: Noise-making electronic devices (cellular phones, pagers, etc.) should not be allowed to disrupt classsessions. Either turn them off or leave them elsewhere.Class email lists will be used. These lists will use your University of Memphis email account. If youdo not regularly check that account, make sure your email is forwarded to the account you do use(go to iam.memphis.edu to set up email forwarding).Documents will be made available to students via the WWW(http://www.chem.memphis.edu/parrill/chem4315/index2005.html).It is expected that every student will submit evidence of his or her own individual understanding andeffort. Students are encouraged, however, to discuss their individual projects with other studentsand other professors. Any type of academic dishonesty will be met with severe penalties, andwill be handled on an individual basis.15151555

CHEM 4315/6315: Related JournalsJournalsJournal of Medicinal ChemistryBioorganic and Medicinal ChemistryBioorganic and Medicinal Chemistry LettersScienceNatureJournal of the American Chemical SocietyBiochemistryJournal of Biological Chemistry