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Pawel Bednarek, Michal Jasinski - PolSCA

Pawel Bednarek, Michal Jasinski - PolSCA

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RNA in plant gene regulationStructural and functional studies of Dicer-like proteins from Medicago truncatulaDCL1 produces miRNADCL1DCL2 - 4 produce siRNAG. intestinalis Dicer(the only full-length Dicerstructure currently available)We currently focus onMtDCL1 & MtDCL2:structural studiescomparative activityanalysis of the enzymes ondivergent substratesDCL4Ian J. MacRae, et al. Structural Basis forDouble-Stranded RNA Processing by Dicer.Science 311, 195 (2006).

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