Novel genetic and epigenetic alterations in ... - Ous-research.no
Novel genetic and epigenetic alterations in ... - Ous-research.no Novel genetic and epigenetic alterations in ... - Ous-research.no
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References206. Esteller M (2007) Cancer epigenomics: DNA methylomes and histonemodificationmaps. Nat Rev Genet 8(4): 286-298207. Schuebel KE, Chen W, Cope L, Glockner SC, Suzuki H, Yi JM, Chan TA, Van NL,Van CW, van den BS, van EM, Ting AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N,Herman JG, Baylin SB (2007) Comparing the DNA hypermethylome with genemutations in human colorectal cancer. PLoS Genet 3(9): 1709-1723208. Costello JF, Fruhwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, WrightFA, Feramisco JD, Peltomaki P, Lang JC, Schuller DE, Yu L, Bloomfield CD,Caligiuri MA, Yates A, Nishikawa R, Su HH, Petrelli NJ, Zhang X, O'Dorisio MS,Held WA, Cavenee WK, Plass C (2000) Aberrant CpG-island methylation hasnon-random and tumour-type-specific patterns. Nat Genet 24(2): 132-138209. Liu ET (2008) Functional genomics of cancer. Curr Opin Genet Dev 18(3): 251-256210. Buffart TE, Overmeer RM, Steenbergen RD, Tijssen M, van Grieken NC, SnijdersPJ, Grabsch HI, van d, V, Carvalho B, Meijer GA (2008) MAL promoterhypermethylation as a novel prognostic marker in gastric cancer. Br J Cancer99(11): 1802-180785
- Page 34 and 35: Introductionpopulation-wide screeni
- Page 36 and 37: IntroductionFigure 12. Present and
- Page 38 and 39: RESULTS IN BRIEFPaper Ia. “DNA hy
- Page 40 and 41: Results in Briefinstability, and se
- Page 42 and 43: Results in BriefUnivariate survival
- Page 44 and 45: Discussionseveral factors, and full
- Page 46 and 47: Discussionlow threshold, we increas
- Page 48 and 49: DiscussionIt may seem like unnecess
- Page 50 and 51: Discussionthan 96% DHPLC do not sta
- Page 52 and 53: DiscussionFigure 13. Mutation detec
- Page 54 and 55: DiscussionClinical impact of molecu
- Page 56 and 57: Discussionmarkers with a very high
- Page 58 and 59: Discussionchromosomes in metaphase[
- Page 60 and 61: DiscussionThese examples underline
- Page 62 and 63: Discussiongenes. One is based on mu
- Page 64 and 65: CONCLUSIONSWe have identified novel
- Page 66 and 67: Future PerspectivesMolecular risk a
- Page 68 and 69: REFERENCES1. Breasted J (1930) The
- Page 70 and 71: References29. Deng G, Chen A, Pong
- Page 72 and 73: References57. Al-Sukhni W, Aronson
- Page 74 and 75: References84. Kunkel TA (1993) Nucl
- Page 76 and 77: ReferencesLeggett B, Levine J, Kim
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- Page 80 and 81: References156. Meling GI, Lothe RA,
- Page 82 and 83: ReferencesT, Song X, Day RH, Sledzi
- Page 86 and 87: ORIGINAL ARTICLESAPPENDIXAppendix I
- Page 89 and 90: GASTROENTEROLOGY 2007;132:1631-1639
- Page 91: Paper IbGuro E Lind, Terje Ahlquist
- Page 94 and 95: Journal of Translational Medicine 2
- Page 96 and 97: Journal of Translational Medicine 2
- Page 98 and 99: Journal of Translational Medicine 2
- Page 100 and 101: Journal of Translational Medicine 2
- Page 102 and 103: Journal of Translational Medicine 2
- Page 105: Paper IITerje Ahlquist, Guro E Lind
- Page 108 and 109: BackgroundMost cases of colorectal
- Page 110 and 111: ADAMTS1 CDKN2A CRABP1 HOXA9 MAL MGM
- Page 112 and 113: pseudogene, leading to a high rate
- Page 114 and 115: strands. Proc Natl Acad Sci U S A 1
- Page 116 and 117: concomitant absence of transcript a
- Page 119 and 120: Volume 10 Number 7 July 2008 pp. 68
- Page 121 and 122: 682 RAS Signaling in Colorectal Car
- Page 123 and 124: 684 RAS Signaling in Colorectal Car
- Page 125 and 126: 686 RAS Signaling in Colorectal Car
- Page 127: Table W2. Detailed Somatic Events o
- Page 131 and 132: Identification of RCC2 as a prognos
- Page 133 and 134: INTRODUCTIONMicrosatellite instabil
References206. Esteller M (2007) Cancer epige<strong>no</strong>mics: DNA methylomes <strong>and</strong> histonemodificationmaps. Nat Rev Genet 8(4): 286-298207. Schuebel KE, Chen W, Cope L, Glockner SC, Suzuki H, Yi JM, Chan TA, Van NL,Van CW, van den BS, van EM, T<strong>in</strong>g AH, Jair K, Yu W, Toyota M, Imai K, Ahuja N,Herman JG, Bayl<strong>in</strong> SB (2007) Compar<strong>in</strong>g the DNA hypermethylome with genemutations <strong>in</strong> human colorectal cancer. PLoS Genet 3(9): 1709-1723208. Costello JF, Fruhwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, WrightFA, Feramisco JD, Peltomaki P, Lang JC, Schuller DE, Yu L, Bloomfield CD,Caligiuri MA, Yates A, Nishikawa R, Su HH, Petrelli NJ, Zhang X, O'Dorisio MS,Held WA, Cavenee WK, Plass C (2000) Aberrant CpG-isl<strong>and</strong> methylation has<strong>no</strong>n-r<strong>and</strong>om <strong>and</strong> tumour-type-specific patterns. Nat Genet 24(2): 132-138209. Liu ET (2008) Functional ge<strong>no</strong>mics of cancer. Curr Op<strong>in</strong> Genet Dev 18(3): 251-256210. Buffart TE, Overmeer RM, Steenbergen RD, Tijssen M, van Grieken NC, SnijdersPJ, Grabsch HI, van d, V, Carvalho B, Meijer GA (2008) MAL promoterhypermethylation as a <strong>no</strong>vel prog<strong>no</strong>stic marker <strong>in</strong> gastric cancer. Br J Cancer99(11): 1802-180785