Novel genetic and epigenetic alterations in ... - Ous-research.no
Novel genetic and epigenetic alterations in ... - Ous-research.no Novel genetic and epigenetic alterations in ... - Ous-research.no
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Referencesquantitative real-time RT-PCR for colorectal cancer diagnosis. Cancer Sci99(10): 1977-1983168. Muller HM, Oberwalder M, Fiegl H, Morandell M, Goebel G, Zitt M, Muhlthaler M,Ofner D, Margreiter R, Widschwendter M (2004) Methylation changes in faecalDNA: a marker for colorectal cancer screening? Lancet 363(9417): 1283-1285169. Chen WD, Han ZJ, Skoletsky J, Olson J, Sah J, Myeroff L, Platzer P, Lu S, DawsonD, Willis J, Pretlow TP, Lutterbaugh J, Kasturi L, Willson JK, Rao JS, Shuber A,Markowitz SD (2005) Detection in fecal DNA of colon cancer-specificmethylation of the nonexpressed vimentin gene. J Natl Cancer Inst 97(15): 1124-1132170. Lofton-Day C, Model F, Devos T, Tetzner R, Distler J, Schuster M, Song X, LescheR, Liebenberg V, Ebert M, Molnar B, Grutzmann R, Pilarsky C, Sledziewski A(2008) DNA methylation biomarkers for blood-based colorectal cancerscreening. Clin Chem 54(2): 414-423171. Itzkowitz SH, Jandorf L, Brand R, Rabeneck L, Schroy PC, III, Sontag S, JohnsonD, Skoletsky J, Durkee K, Markowitz S, Shuber A (2007) Improved fecal DNA testfor colorectal cancer screening. Clin Gastroenterol Hepatol 5(1): 111-117172. Oberwalder M, Zitt M, Wontner C, Fiegl H, Goebel G, Zitt M, Kohle O, MuhlmannG, Ofner D, Margreiter R, Muller HM (2008) SFRP2 methylation in fecal DNA--amarker for colorectal polyps. Int J Colorectal Dis 23(1): 15-19173. Wang DR, Tang D (2008) Hypermethylated SFRP2 gene in fecal DNA is a highpotential biomarker for colorectal cancer noninvasive screening. World JGastroenterol 14(4): 524-531174. Huang Z, Li L, Wang J (2007) Hypermethylation of SFRP2 as a potential markerfor stool-based detection of colorectal cancer and precancerous lesions. DigDis Sci 52(9): 2287-2291175. Tan SH, Ida H, Lau QC, Goh BC, Chieng WS, Loh M, Ito Y (2007) Detection ofpromoter hypermethylation in serum samples of cancer patients bymethylation-specific polymerase chain reaction for tumour suppressor genesincluding RUNX3. Oncol Rep 18(5): 1225-1230176. Nakayama G, Hibi K, Nakayama H, Kodera Y, Ito K, Akiyama S, Nakao A (2007) Ahighly sensitive method for the detection of p16 methylation in the serum ofcolorectal cancer patients. Anticancer Res 27(3B): 1459-1463177. Leung WK, To KF, Man EP, Chan MW, Bai AH, Hui AJ, Chan FK, Sung JJ (2005)Quantitative detection of promoter hypermethylation in multiple genes in theserum of patients with colorectal cancer. Am J Gastroenterol 100(10): 2274-2279178. Grutzmann R, Molnar B, Pilarsky C, Habermann JK, Schlag PM, Saeger HD,Miehlke S, Stolz T, Model F, Roblick UJ, Bruch HP, Koch R, Liebenberg V, Devos81
- Page 30 and 31: Introductionthere seems to be a fid
- Page 32 and 33: Introductionsevere alterations are
- Page 34 and 35: Introductionpopulation-wide screeni
- Page 36 and 37: IntroductionFigure 12. Present and
- Page 38 and 39: RESULTS IN BRIEFPaper Ia. “DNA hy
- Page 40 and 41: Results in Briefinstability, and se
- Page 42 and 43: Results in BriefUnivariate survival
- Page 44 and 45: Discussionseveral factors, and full
- Page 46 and 47: Discussionlow threshold, we increas
- Page 48 and 49: DiscussionIt may seem like unnecess
- Page 50 and 51: Discussionthan 96% DHPLC do not sta
- Page 52 and 53: DiscussionFigure 13. Mutation detec
- Page 54 and 55: DiscussionClinical impact of molecu
- Page 56 and 57: Discussionmarkers with a very high
- Page 58 and 59: Discussionchromosomes in metaphase[
- Page 60 and 61: DiscussionThese examples underline
- Page 62 and 63: Discussiongenes. One is based on mu
- Page 64 and 65: CONCLUSIONSWe have identified novel
- Page 66 and 67: Future PerspectivesMolecular risk a
- Page 68 and 69: REFERENCES1. Breasted J (1930) The
- Page 70 and 71: References29. Deng G, Chen A, Pong
- Page 72 and 73: References57. Al-Sukhni W, Aronson
- Page 74 and 75: References84. Kunkel TA (1993) Nucl
- Page 76 and 77: ReferencesLeggett B, Levine J, Kim
- Page 78 and 79: References133. Lind GE, Thorstensen
- Page 82 and 83: ReferencesT, Song X, Day RH, Sledzi
- Page 84 and 85: References196. Honda S, Haruta M, S
- Page 86 and 87: ORIGINAL ARTICLESAPPENDIXAppendix I
- Page 89 and 90: GASTROENTEROLOGY 2007;132:1631-1639
- Page 91: Paper IbGuro E Lind, Terje Ahlquist
- Page 94 and 95: Journal of Translational Medicine 2
- Page 96 and 97: Journal of Translational Medicine 2
- Page 98 and 99: Journal of Translational Medicine 2
- Page 100 and 101: Journal of Translational Medicine 2
- Page 102 and 103: Journal of Translational Medicine 2
- Page 105: Paper IITerje Ahlquist, Guro E Lind
- Page 108 and 109: BackgroundMost cases of colorectal
- Page 110 and 111: ADAMTS1 CDKN2A CRABP1 HOXA9 MAL MGM
- Page 112 and 113: pseudogene, leading to a high rate
- Page 114 and 115: strands. Proc Natl Acad Sci U S A 1
- Page 116 and 117: concomitant absence of transcript a
- Page 119 and 120: Volume 10 Number 7 July 2008 pp. 68
- Page 121 and 122: 682 RAS Signaling in Colorectal Car
- Page 123 and 124: 684 RAS Signaling in Colorectal Car
- Page 125 and 126: 686 RAS Signaling in Colorectal Car
- Page 127: Table W2. Detailed Somatic Events o
Referencesquantitative real-time RT-PCR for colorectal cancer diag<strong>no</strong>sis. Cancer Sci99(10): 1977-1983168. Muller HM, Oberwalder M, Fiegl H, Mor<strong>and</strong>ell M, Goebel G, Zitt M, Muhlthaler M,Ofner D, Margreiter R, Widschwendter M (2004) Methylation changes <strong>in</strong> faecalDNA: a marker for colorectal cancer screen<strong>in</strong>g? Lancet 363(9417): 1283-1285169. Chen WD, Han ZJ, Skoletsky J, Olson J, Sah J, Myeroff L, Platzer P, Lu S, DawsonD, Willis J, Pretlow TP, Lutterbaugh J, Kasturi L, Willson JK, Rao JS, Shuber A,Markowitz SD (2005) Detection <strong>in</strong> fecal DNA of colon cancer-specificmethylation of the <strong>no</strong>nexpressed viment<strong>in</strong> gene. J Natl Cancer Inst 97(15): 1124-1132170. Lofton-Day C, Model F, Devos T, Tetzner R, Distler J, Schuster M, Song X, LescheR, Liebenberg V, Ebert M, Molnar B, Grutzmann R, Pilarsky C, Sledziewski A(2008) DNA methylation biomarkers for blood-based colorectal cancerscreen<strong>in</strong>g. Cl<strong>in</strong> Chem 54(2): 414-423171. Itzkowitz SH, J<strong>and</strong>orf L, Br<strong>and</strong> R, Rabeneck L, Schroy PC, III, Sontag S, JohnsonD, Skoletsky J, Durkee K, Markowitz S, Shuber A (2007) Improved fecal DNA testfor colorectal cancer screen<strong>in</strong>g. Cl<strong>in</strong> Gastroenterol Hepatol 5(1): 111-117172. Oberwalder M, Zitt M, Wontner C, Fiegl H, Goebel G, Zitt M, Kohle O, MuhlmannG, Ofner D, Margreiter R, Muller HM (2008) SFRP2 methylation <strong>in</strong> fecal DNA--amarker for colorectal polyps. Int J Colorectal Dis 23(1): 15-19173. Wang DR, Tang D (2008) Hypermethylated SFRP2 gene <strong>in</strong> fecal DNA is a highpotential biomarker for colorectal cancer <strong>no</strong>n<strong>in</strong>vasive screen<strong>in</strong>g. World JGastroenterol 14(4): 524-531174. Huang Z, Li L, Wang J (2007) Hypermethylation of SFRP2 as a potential markerfor stool-based detection of colorectal cancer <strong>and</strong> precancerous lesions. DigDis Sci 52(9): 2287-2291175. Tan SH, Ida H, Lau QC, Goh BC, Chieng WS, Loh M, Ito Y (2007) Detection ofpromoter hypermethylation <strong>in</strong> serum samples of cancer patients bymethylation-specific polymerase cha<strong>in</strong> reaction for tumour suppressor genes<strong>in</strong>clud<strong>in</strong>g RUNX3. Oncol Rep 18(5): 1225-1230176. Nakayama G, Hibi K, Nakayama H, Kodera Y, Ito K, Akiyama S, Nakao A (2007) Ahighly sensitive method for the detection of p16 methylation <strong>in</strong> the serum ofcolorectal cancer patients. Anticancer Res 27(3B): 1459-1463177. Leung WK, To KF, Man EP, Chan MW, Bai AH, Hui AJ, Chan FK, Sung JJ (2005)Quantitative detection of promoter hypermethylation <strong>in</strong> multiple genes <strong>in</strong> theserum of patients with colorectal cancer. Am J Gastroenterol 100(10): 2274-2279178. Grutzmann R, Molnar B, Pilarsky C, Habermann JK, Schlag PM, Saeger HD,Miehlke S, Stolz T, Model F, Roblick UJ, Bruch HP, Koch R, Liebenberg V, Devos81