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LIST OF PAPERSIaGuro E Lind, Terje Ahlquist, Ragnhild A Lothe. DNA Hypermethylation of MAL:A Promising Diagnostic Biomarker for Colorectal Tumors. Gastroenterology. 2007.Apr;132(4):1631-2IbGuro E Lind, Terje Ahlquist, Matthias Kolberg, Marianne Berg, Mette Eknæs,Miguel A Alonso, Anne Kallioniemi, Gunn I Meling, Rolf I Skotheim, Torleiv ORognum, Espen Thiis-Evensen and Ragnhild A Lothe. Hypermethylated MAL gene– a silent marker of early colon tumorigenesis. 2008. Journal of TranslationalMedicine. Mar 17;6:13.IITerje Ahlquist, Guro E Lind, Vera L Costa, Gunn I Meling, Morten Vatn, Geir SHoff, Torleiv O Rognum, Rolf I Skotheim, Espen Thiis-Evensen and Ragnhild ALothe. Gene methylation profiles of normal mucosa, and benign and malignantcolorectal tumors identify early onset markers. 2008. Molecular Cancer – In pressIIITerje Ahlquist, Irene Bottillo, Stine A Danielsen, Gunn I Meling, Torleiv ORognum, Guro E Lind, Bruno Dallapiccola and Ragnhild A Lothe. RAS signaling incolorectal carcinomas through alterations of RAS, RAF, NF1 and/or RASSF1A.2008. Neoplasia. Jul;10(7):680-6.IVTerje Ahlquist, Ellen C Røyrvik, Marianne Merok, Gunn I Meling, AnnikaLindblom, Xiao-Feng Sun, Georgia Bardi, Arild Nesbakken and Ragnhild A Lothe.Identification of RCC2 as a prognostic marker among multiple gene mutations incolorectal cancer with defect mismatch repair. Manuscript.Associated paper:Ellen C Røyrvik, Terje Ahlquist, Torbjørn Rognes and Ragnhild A Lothe. Slipslidin' away: a duodecennial review of targeted genes in mismatch repair deficientcolorectal cancer. Critical Reviews in Oncogenesis. 2007 Dec;13(3):229-57.8
Page 1 and 2: Novel genetic and epigenetic altera
Page 3 and 4: TABLE OF CONTENTSACKNOWLEDGEMENTS .
Page 5 and 6: ACKNOWLEDGEMENTSThe present work ha
Page 7: Prefacetechnology[3]. This new tech
Page 11 and 12: GENERAL INTRODUCTIONGenetic and epi
Page 13 and 14: IntroductionThe genes involved in m
Page 15 and 16: Introductionexemplified by frequent
Page 17 and 18: IntroductionFigure 3. Methylation e
Page 19 and 20: IntroductionEven though this study
Page 21 and 22: IntroductionA rapidly growing field
Page 23 and 24: IntroductionFigure 7. Colorectal ca
Page 25 and 26: IntroductionFigure 9. A timeline of
Page 27 and 28: IntroductionFigure 10. Molecular pa
Page 29 and 30: Introductiondefective DNA mismatch
Page 31 and 32: IntroductionFigure 11. Integrated g
Page 33 and 34: Introductionthird of human cancers[
Page 35 and 36: Introductionpatients with MSI tumor
Page 37 and 38: AIMSThe overall aim of this study i
Page 39 and 40: Results in Briefwas determined by u
Page 41 and 42: Results in Briefnine tumors display
Page 43 and 44: DISCUSSIONFresh-frozen versus forma
Page 45 and 46: DiscussionSince MSP only gives info
Page 47 and 48: Discussiondepends on the requiremen
Page 49 and 50: DiscussionDNA fragments to the colu
Page 51 and 52: Discussionthe sequencing technology
Page 53 and 54: Discussionserve as positive control
Page 55 and 56: Discussionrespectively[169;171]. Se
Page 57 and 58: DiscussionEven though the subgroup
Page 59 and 60:
Discussionwere mutated[191]. The re
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DiscussionIn paper IV, our aim was
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DiscussionDifferent origins of colo
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FUTURE PERSPECTIVESHigh throughput
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Future Perspectivesand follow up. C
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References14. Grady WM, Carethers J
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References43. Feinberg AP, Vogelste
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References71. O'Brien MJ, Yang S, M
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References97. Samowitz WS, Albertse
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References122. Thiis-Evensen E, Hof
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References145. Oefner PJ, Underhill
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Referencesquantitative real-time RT
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Referencesand histology in sporadic
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References206. Esteller M (2007) Ca
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Paper IaGuro E Lind, Terje Ahlquist
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1632 CORRESPONDENCE GASTROENTEROLOG
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Journal of Translational MedicineBi
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Journal of Translational Medicine 2
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Page 99 and 100:
Page 101 and 102:
Page 103:
Page 107 and 108:
Gene methylation profiles of normal
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Quantitative MSPPrimers and probes
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An association between hypermethyla
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samples taken distant from MSI- and
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36. Khan S, Kumagai T, Vora J, Bose
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Paper IIITerje Ahlquist, Irene Bott
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Neoplasia Vol. 10, No. 7, 2008 RAS
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Page 124 and 125:
Page 126 and 127:
Table W1. Primer Sequences and dHPL
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Paper IVTerje Ahlquist, Ellen C Rø
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ABSTRACTColorectal cancer (CRC) is
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tumors it is hard to establish whic
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embedded carcinomas was analyzed in
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up with ExoSAP-IT (USB Corporation,
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RESULTSMSI-analysisTumors with know
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Figure 1. Mutation frequencies acro
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Figure 3.Representativeelectrophero
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ACVR2 ASTE1 CASP5 MARCKS MBD4 MRE11
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DISCUSSIONColorectal cancer is a ve
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had mutation frequencies of 75% or
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Previous studies have shown that RC
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REFERENCES1. Grady WM, Carethers JM
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Studies on p53, BAX and Bcl-2 prote
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Gene name Multiplex Annealing Numbe
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Appendix I - List of abbreviations5
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RØYRVIK ET AL.2plastic properties.
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RØYRVIK ET AL.was, by reverse gene
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RØYRVIK ET AL.the PubMed database;
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RØYRVIK ET AL.TABLE I, continuedMu
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RØYRVIK ET AL.TABLE I, continuedMu
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RØYRVIK ET AL.gene must be validat
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RØYRVIK ET AL.Another topic that d
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RØYRVIK ET AL.22. Bodmer WF. Cance
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RØYRVIK ET AL.lite instability in
Page 182 and 183:
RØYRVIK ET AL.Roche PC, Smith DI,
Page 184 and 185:
RØYRVIK ET AL.instability high (MS
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RØYRVIK ET AL.112. Ionov Y, Matsui
Page 188 and 189:
RØYRVIK ET AL.133. Guanti G, Resta
Page 190 and 191:
RØYRVIK ET AL.155. Li YC, Korol AB
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