Novel genetic and epigenetic alterations in ... - Ous-research.no

TARGET GENES OF MSI COLORECTAL CANCER123. Ohmiya N, Matsumoto S, Yamamoto H, Baranovskaya S, Malkhosyan SR, PeruchoM. Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinalcancers of the microsatellite mutator phenotype. Gene. 2001;272:301–13.124. Ouyang H, Shiwaku HO, Hagiwara H, Miura K, Abe T, Kato Y, Ohtani H,Shiiba K, Souza RF, Meltzer SJ, Horii A. The insulin-like growth factor II receptorgene is mutated in genetically unstable cancers of the endometrium,stomach, and colorectum. Cancer Res. 1997;57:1851–4.125. Bader S, Walker M, Hendrich B, Bird A, Bird C, Hooper M, Wyllie A. Somaticframeshift mutations in the MBD4 gene of sporadic colon cancers with mismatchrepair deficiency. Oncogene. 1999;18:8044–7.126. Riccio A, Aaltonen LA, Godwin AK, Loukola A, Percesepe A, Salovaara R,Masciullo V, Genuardi M, Paravatou-Petsotas M, Bassi DE, Ruggeri BA,Klein-Szanto AJ, Testa JR, Neri G, Bellacosa A. The DNA repair gene MBD4(MED1) is mutated in human carcinomas with microsatellite instability. NatGenet. 1999;23:266–8.127. Yamada T, Koyama T, Ohwada S, Tago K, Sakamoto I, Yoshimura S, HamadaK, Takeyoshi I, Morishita Y. Frameshift mutations in the MBD4/MED1 genein primary gastric cancer with high-frequency microsatellite instability. CancerLett. 2002;181:115–20.128. Pinto M, Wu Y, Suriano G, Mensink RG, Duval A, Oliveira C, Carvalho B,Hamelin R, Seruca R, Hofstra RM. MBD4 mutations are rare in gastric carcinomaswith microsatellite instability. Cancer Genet Cytogenet. 2003;145:103–7.129. Loukola A, Vilkki S, Singh J, Launonen V, Aaltonen LA. Germline and somaticmutation analysis of MLH3 in MSI-positive colorectal cancer. Am JPathol. 2000;157:347–52.130. Giannini G, Ristori E, Cerignoli F, Rinaldi C, Zani M, Viel A, Ottini L, CrescenziM, Martinotti S, Bignami M, Frati L, Screpanti I, Gulino A. HumanMRE11 is inactivated in mismatch repair-deficient cancers. EMBO Rep.2002;3:248–54.131. Ottini L, Falchetti M, Saieva C, De MM, Masala G, Zanna I, Paglierani M,Giannini G, Gulino A, Nesi G, Mariani CR, Palli D. MRE11 expression is impairedin gastric cancer with microsatellite instability. Carcinogenesis.2004;25:2337–43.132. Giannini G, Rinaldi C, Ristori E, Ambrosini MI, Cerignoli F, Viel A, Bidoli E,Berni S, D'Amati G, Scambia G, Frati L, Screpanti I, Gulino A. Mutations ofan intronic repeat induce impaired MRE11 expression in primary human cancerwith microsatellite instability. Oncogene. 2004;23:2640–7.253