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Novel genetic and epigenetic alterations in ... - Ous-research.no

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RØYRVIK ET AL.<strong>in</strong>stability high (MSI-H) colon cancers correlates with cl<strong>in</strong>ico-pathological parameters:A study of the TGRbetaRII, BAX, hMSH3, hMSH6, IGFIIR <strong>and</strong>BLM genes. Int J Cancer. 2000;89:230–5.91. Catasus L, Matias-Guiu X, Mach<strong>in</strong> P, Zan<strong>no</strong>ni GF, Scambia G, edetti-PaniciP, Prat J. Frameshift mutations at cod<strong>in</strong>g mo<strong>no</strong>nucleotide repeat microsatellites<strong>in</strong> endometrial carc<strong>in</strong>oma with microsatellite <strong>in</strong>stability. Cancer. 2000;88:2290–7.92. Johannsdottir JT, Jonasson JG, Bergthorsson JT, Amundadottir LT, MagnussonJ, Egilsson V, Ingvarsson S. The effect of mismatch repair deficiency on tumourigenesis;microsatellite <strong>in</strong>stability affect<strong>in</strong>g genes conta<strong>in</strong><strong>in</strong>g short repeatedsequences. Int J Oncol. 2000;16:133–9.93. Percesepe A, Pedroni M, Sala E, Menigatti M, Borghi F, Losi L, Viel A, GenuardiM, Benatti P, Roncucci L, Peltomaki P, Ponz de LM. Ge<strong>no</strong>mic <strong>in</strong>stability<strong>and</strong> target gene mutations <strong>in</strong> colon cancers with different degrees of allelicshifts. Genes Chromosomes Cancer. 2000;27:424–9.94. Semba S, Ouyang H, Han SY, Kato Y, Horii A. Analysis of the c<strong>and</strong>idate targetgenes for mutation <strong>in</strong> microsatellite <strong>in</strong>stability-positive cancers of the colorectum,stomach, <strong>and</strong> endometrium. Int J Oncol. 2000;16:731–7.95. Simms LA, Young J, Wick<strong>in</strong>g C, Meltzer SJ, Jass JR, Leggett BA. The apoptoticregulatory gene, BCL10, is mutated <strong>in</strong> sporadic mismatch repair deficientcolorectal cancers. Cell Death Differ. 2000;7:236–7.96. Cal<strong>in</strong> G, Ranzani GN, Amadori D, Herlea V, Matei I, Barbanti-Broda<strong>no</strong> G,Negr<strong>in</strong>i M. Somatic frameshift mutations <strong>in</strong> the Bloom syndrome BLM geneare frequent <strong>in</strong> sporadic gastric carc<strong>in</strong>omas with microsatellite mutator phe<strong>no</strong>type.BMC Genet. 2001;2:14. Epub. 2001 Aug 14.14.97. Gras E, Catasus L, Arguelles R, More<strong>no</strong>-Bue<strong>no</strong> G, Palacios J, Gamallo C, Matias-GuiuX, Prat J. Microsatellite <strong>in</strong>stability, MLH-1 promoter hypermethylation,<strong>and</strong> frameshift mutations at cod<strong>in</strong>g mo<strong>no</strong>nucleotide repeat microsatellites<strong>in</strong> ovarian tumors. Cancer. 2001;92:2829–36.98. Lee HS, Lee BL, Kim SH, Woo DK, Kim HS, Kim WH. Microsatellite <strong>in</strong>stability<strong>in</strong> synchro<strong>no</strong>us gastric carc<strong>in</strong>omas. Int J Cancer. 2001;91:619–24.99. Miyaki M, Iijima T, Shiba K, Aki T, Kita Y, Yasu<strong>no</strong> M, Mori T, Kuroki T,Iwama T. Alterations of repeated sequences <strong>in</strong> 5' upstream <strong>and</strong> cod<strong>in</strong>g regions<strong>in</strong> colorectal tumors from patients with hereditary <strong>no</strong>npolyposis colorectal cancer<strong>and</strong> Turcot syndrome. Oncogene. 2001;20:5215–8.100. Sh<strong>in</strong> KH, Park YJ, Park JG. PTEN gene mutations <strong>in</strong> colorectal cancers display<strong>in</strong>gmicrosatellite <strong>in</strong>stability. Cancer Lett. 2001;174:189–94.101. Togo G, Shiratori Y, Okamoto M, Yamaji Y, Matsumura M, Sa<strong>no</strong> T, MotojimaT, Omata M. Relationship between grade of microsatellite <strong>in</strong>stability <strong>and</strong> target250

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