Novel genetic and epigenetic alterations in ... - Ous-research.no

TARGET GENES OF MSI COLORECTAL CANCERTABLE I, continuedMutation frequencies of microsatellite-containing genesGene HGNC RepeatChr. Location(tot) S/C %(S/C)Mut % Mut. MutKIAA0595 PPRC1 (C)8 10q24.32 7 % 3/43 7 %KIAA0754 (A)8 1p34.3 10 % 4/41 10 %KIAA0844 ZNF365 (A)8 10q21.2 9 % 4/44 9 %KIAA0905 SEC31A (A)9 4q21.22 17 % 6/43 14 %KIAA0943 ATG4B (T)9 2q37.3 11 % 4/44 9 %KIAA0977 COBLL1 (T)9 2q24.3 20 % 10/42 24 %KIAA1052 CEP164 (A)11 11q23.3 31 % 12/39 31 %KIAA1268 PARP14 (A)10 3q21.1 23 % 9/39 23 %KIAA1333 KIAA1333 (A)10 14q12 21 % 8/39 21 %KIAA1470 RCC2 (A)10 1p36.13 46 % 18/39 46 %KKIAMRE CDKL2 (A)9 4q21.1 4 % 2/57 4 %MAC30 TMEM97 (A)10 17q11.2 17 % 9/60 15 %MARCKS MARCKS (A)11 6q22.2 74 % 42/58 72 %MAZ MAZ (C)8 16p11.2 8 % 3/38 8 %MBD4 MBD4 (A)10 3q21.3 24 % 76/384 20 %MCT4 SLC16A4 (T)9 1p12 15 % 4/36 11 %MKI67 MKI67 (A)8 10q26.2 18 %MLH3 MLH3 (A)9 14q24.3 8 % 4/27 15 %MRE11 MRE11A (T)11 11q21 75 % 55/64 86 %MRP2 ABCC2 (A)8 10q24 8 % 3/38 8 %MYO10 MYO10 (G)8 5p15.1 11 % 4/38 11 %NBS1 NBN (A)7 8q21.3 0 % 0/39 0 %NDUFC2 NDUFC2 (T)9 11q14.1 31 % 12/43 28 %NKTR NKTR (C)8 4q32.1 7 % 3/43 7 %NSEP YBX1 (C)8 1p34.2 0 % 0/82 0 %OGT OGT (T)10 Xq13.1 22 % 26/116 22 %P4HB P4HB (A)8 17q25.3 10 % 3/42 7 %PA2G4 PA2G4 (A)8 12q13.2 18 % 9/43 21 %PMS2 PMS2 (A)8 7p22.1 2 % 5/207 2 %POLA POLA1 (A)8 Xp22.11 0 % 0/66 0 %PRCC PRCC (C)8 1q21.1 12 %PRKCI PRKCI (A)8 3q26.2 11 %PRKWNK1 WNK1 (A)10 12p13.3 23 % 9/39 23 %PRRG1 PRRG1 (C)8 Xp21.1 9 % 4/43 9 %PTEN PTEN (A)6 * 2 10q23.31 17 % 26/138 19 %PTHL3 PTHLH (A)11 12p11.22 91 % 18/20 90 %PTPN21 PTPN21 (A)8 14q31.3 13 % 5/43 12 %RAB2L RGL2 (G)8 6p21.3 12 % 5/43 12 %RACK7 ZMYND8 (A)8 20q13.12 15 % 20/135 15 %RBBP2 JARID1A (A)8 12p11 17 %RBBP8 RBBP8 (A)9 18q11.2 17 % 30/179 17 %RECQL RECQL (A)9 12p12.1 8 % 19/213 9 %RFC3 RFC3 (A)1013q12.3-1321 % 8/39 21 %RGS12 RGS12 (C)8 4p16.3 29 % 11/38 29 %Refs.55555555,5655,5655,56444444444944,53,5644,52,54,5910517,44,53,55,56,59,62,67,99,125-12855,5656122,12965,67,130-1321051056454-565546,71,8744,49,5355,5655,5666,71,87,111,12671,1115656445559,69,100,133-13753,54,5955,565555,665649,61,115,13817,49,66,11144105237