Novel genetic and epigenetic alterations in ... - Ous-research.no

strands. Proc Natl Acad Sci U S A 1992, 89:1827-1831.8. Herman JG, Graff JR, Myöhänen S, Nelkin BD, BaylinSB: Methylation-specific PCR: a novel PCR assayfor methylation status of CpG islands. Proc NatlAcad Sci U S A 1996, 93:9821-9826.9. Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO, Lothe RA: ADAMTS1,CRABP1, and NR3C1 identified as epigeneticallyderegulated genes in colorectal tumorigenesis. CellOncol 2006, 28:259-272.10. Lind GE, Ahlquist T, Lothe RA: DNA hypermethylationof MAL: a promising diagnostic biomarker forcolorectal tumors. Gastroenterology 2007, 132:1631-1632.11. Lind GE, Thorstensen L, Løvig T, Meling GI, HamelinR, Rognum TO, Esteller M, Lothe RA: A CpG islandhypermethylation profile of primary colorectalcarcinomas and colon cancer cell lines. Mol Cancer2004, 3:28.12. Eads CA, Lord RV, Wickramasinghe K, Long TI,Kurumboor SK, Bernstein L, Peters JH, DeMeester SR,DeMeester TR, Skinner KA et al.: Epigenetic patternsin the progression of esophageal adenocarcinoma.Cancer Res 2001, 61:3410-3418.13. Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M,Alonso MA, Kallioniemi A, Meling GI, Skotheim RI,Rognum TO et al.: Hypermethylated MAL gene - asilent marker of early colon tumorigenesis. J TranslMed 2008, 6:13.:13.14. Nagasaka T, Goel A, Notohara K, Takahata T,Sasamoto H, Uchida T, Nishida N, Tanaka N, BolandCR, Matsubara N: Methylation pattern of the O6-methylguanine-DNA methyltransferase gene incolon during progressive colorectal tumorigenesis.Int J Cancer 2008, 122:2429-2436.15. Bai AH, Tong JH, To KF, Chan MW, Man EP, Lo KW,Lee JF, Sung JJ, Leung WK: Promoterhypermethylation of tumor-related genes in theprogression of colorectal neoplasia. Int J Cancer2004, 112:846-853.16. Ahlquist T, Bottillo I, Danielsen SA, Meling GI, RognumTO, Lind GE, Dallapiccola B, Lothe RA: RAS signalingin colorectal carcinomas through alteration of RAS,RAF, NF1, and/or RASSF1A. Neoplasia 2008, 10:680-6, 2.17. Diep CB, Thorstensen L, Meling GI, Skovlund E,Rognum TO, Lothe RA: Genetic tumor markers withprognostic impact in Dukes' stages B and Ccolorectal cancer patients. J Clin Oncol 2003,21:820-829.18. Esteller M, Hamilton SR, Burger PC, Baylin SB,Herman JG: Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoterhypermethylation is a common event in primaryhuman neoplasia. Cancer Res 1999, 59:793-797.19. Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R,Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S etal.: HIN-1, a putative cytokine highly expressed innormal but not cancerous mammary epithelial cells.Proc Natl Acad Sci U S A 2001, 98:9796-9801.20. Alaminos M, Davalos V, Cheung NK, Gerald WL,Esteller M: Clustering of gene hypermethylationassociated with clinical risk groups inneuroblastoma. J Natl Cancer Inst 2004, 96:1208-1219.21. Goel A, Arnold CN, Tassone P, Chang DK, NiedzwieckiD, Dowell JM, Wasserman L, Compton C, Mayer RJ,Bertagnolli MM et al.: Epigenetic inactivation ofRUNX3 in microsatellite unstable sporadic coloncancers. Int J Cancer 2004, 112:754-759.22. Costello JF, Fruhwald MC, Smiraglia DJ, Rush LJ,Robertson GP, Gao X, Wright FA, Feramisco JD,Peltomaki P, Lang JC et al.: Aberrant CpG-islandmethylation has non-random and tumour-typespecificpatterns. Nat Genet 2000, 24:132-138.23. Hayashi H, Nagae G, Tsutsumi S, Kaneshiro K, KozakiT, Kaneda A, Sugisaki H, Aburatani H: High-resolutionmapping of DNA methylation in human genomeusing oligonucleotide tiling array. Hum Genet 2007,120:701-711.24. Schuebel KE, Chen W, Cope L, Glockner SC, SuzukiH, Yi JM, Chan TA, Van NL, Van CW, van den BS etal.: Comparing the DNA hypermethylome with genemutations in human colorectal cancer. PLoS Genet2007, 3:1709-1723.25. Kuno K, Bannai K, Hakozaki M, Matsushima K, HiroseK: The carboxyl-terminal half region of ADAMTS-1suppresses both tumorigenicity and experimentaltumor metastatic potential. Biochem Biophys ResCommun 2004, 319:1327-1333.26. Folkman J: Angiogenesis. Annu Rev Med 2006, 57:1-18.27. Novak P, Jensen T, Oshiro MM, Wozniak RJ, NouzovaM, Watts GS, Klimecki WT, Kim C, Futscher BW:Epigenetic inactivation of the HOXA gene cluster inbreast cancer. Cancer Res 2006, 66:10664-10670.28. Strathdee G, Holyoake TL, Sim A, Parker A, OscierDG, Melo JV, Meyer S, Eden T, Dickinson AM,Mountford JC et al.: Inactivation of HOXA genes byhypermethylation in myeloid and lymphoidmalignancy is frequent and associated with poorprognosis. Clin Cancer Res 2007, 13:5048-5055.29. Frigola J, Song J, Stirzaker C, Hinshelwood RA,Peinado MA, Clark SJ: Epigenetic remodeling incolorectal cancer results in coordinate genesuppression across an entire chromosome band.Nat Genet 2006, 38:540-549.30. Alonso MA, Weissman SM: cDNA cloning andsequence of MAL, a hydrophobic proteinassociated with human T-cell differentiation. ProcNatl Acad Sci U S A 1987, 84:1997-2001.31. Marazuela M, Alonso MA: Expression of MAL andMAL2, two elements of the protein machinery forraft-mediated transport, in normal and neoplastichuman tissue. Histol Histopathol 2004, 19:925-933.32. Chan AO, Broaddus RR, Houlihan PS, Issa JP,Hamilton SR, Rashid A: CpG island methylation inaberrant crypt foci of the colorectum. Am J Pathol2002, 160:1823-1830.33. Ahuja N, Li Q, Mohan AL, Baylin SB, Issa JP: Agingand DNA methylation in colorectal mucosa andcancer. Cancer Res 1998, 58:5489-5494.34. Kang YH, Lee HS, Kim WH: Promoter methylationand silencing of PTEN in gastric carcinoma. LabInvest 2002, 82:285-291.35. Baeza N, Weller M, Yonekawa Y, Kleihues P, OhgakiH: PTEN methylation and expression inglioblastomas. Acta Neuropathol (Berl) 2003,106:479-485.8