Novel genetic and epigenetic alterations in ... - Ous-research.no

More documents

Recommendations

Info

Paper IITerje Ahlquist, Guro E Lind, Vera L Costa, Gunn I Meling, MortenVatn, Geir S Hoff, Torleiv O Rognum, Rolf I Skotheim, EspenThiis-Evensen and Ragnhild A Lothe.Gene methylation profiles of normal mucosa, and benign andmalignant colorectal tumors identify early onset markers.Molecular Cancer, In Press
Page 1 and 2:
Novel genetic and epigenetic altera
Page 3 and 4:
TABLE OF CONTENTSACKNOWLEDGEMENTS .
Page 5 and 6:
ACKNOWLEDGEMENTSThe present work ha
Page 7 and 8:
Prefacetechnology[3]. This new tech
Page 10 and 11:
SummaryThe subgroup of carcinomas w
Page 12 and 13:
Introduction“Epigenetic inheritan
Page 14 and 15:
Introductionamino acid change it is
Page 16 and 17:
Introductionmethylation during embr
Page 18 and 19:
IntroductionDNA is most of the time
Page 20 and 21:
IntroductionFigure 5. DNA methylati
Page 22 and 23:
IntroductionFigure 6. Incidence rat
Page 24 and 25:
IntroductionFigure 8. Tumor staging
Page 26 and 27:
Introductioninasmuch as 80% of colo
Page 28 and 29:
IntroductionInstabilities involved
Page 30 and 31:
Introductionthere seems to be a fid
Page 32 and 33:
Introductionsevere alterations are
Page 34 and 35:
Introductionpopulation-wide screeni
Page 36 and 37:
IntroductionFigure 12. Present and
Page 38 and 39:
RESULTS IN BRIEFPaper Ia. “DNA hy
Page 40 and 41:
Results in Briefinstability, and se
Page 42 and 43:
Results in BriefUnivariate survival
Page 44 and 45:
Discussionseveral factors, and full
Page 46 and 47:
Discussionlow threshold, we increas
Page 48 and 49:
DiscussionIt may seem like unnecess
Page 50 and 51:
Discussionthan 96% DHPLC do not sta
Page 52 and 53:
DiscussionFigure 13. Mutation detec
Page 54 and 55: DiscussionClinical impact of molecu
Page 56 and 57: Discussionmarkers with a very high
Page 58 and 59: Discussionchromosomes in metaphase[
Page 60 and 61: DiscussionThese examples underline
Page 62 and 63: Discussiongenes. One is based on mu
Page 64 and 65: CONCLUSIONSWe have identified novel
Page 66 and 67: Future PerspectivesMolecular risk a
Page 68 and 69: REFERENCES1. Breasted J (1930) The
Page 70 and 71: References29. Deng G, Chen A, Pong
Page 72 and 73: References57. Al-Sukhni W, Aronson
Page 74 and 75: References84. Kunkel TA (1993) Nucl
Page 76 and 77: ReferencesLeggett B, Levine J, Kim
Page 78 and 79: References133. Lind GE, Thorstensen
Page 80 and 81: References156. Meling GI, Lothe RA,
Page 82 and 83: ReferencesT, Song X, Day RH, Sledzi
Page 84 and 85: References196. Honda S, Haruta M, S
Page 86 and 87: ORIGINAL ARTICLESAPPENDIXAppendix I
Page 89 and 90: GASTROENTEROLOGY 2007;132:1631-1639
Page 91: Paper IbGuro E Lind, Terje Ahlquist
Page 94 and 95: Journal of Translational Medicine 2
Page 107 and 108: Gene methylation profiles of normal
Page 109 and 110: Quantitative MSPPrimers and probes
Page 111 and 112: An association between hypermethyla
Page 113 and 114: samples taken distant from MSI- and
Page 115 and 116: 36. Khan S, Kumagai T, Vora J, Bose
Page 117: Paper IIITerje Ahlquist, Irene Bott
Page 120 and 121: Neoplasia Vol. 10, No. 7, 2008 RAS
Page 126 and 127: Table W1. Primer Sequences and dHPL
Page 129: Paper IVTerje Ahlquist, Ellen C Rø
Page 132 and 133: ABSTRACTColorectal cancer (CRC) is
Page 134 and 135: tumors it is hard to establish whic
Page 136 and 137: embedded carcinomas was analyzed in
Page 138 and 139: up with ExoSAP-IT (USB Corporation,
Page 140 and 141: RESULTSMSI-analysisTumors with know
Page 142 and 143: Figure 1. Mutation frequencies acro
Page 144 and 145: Figure 3.Representativeelectrophero
Page 146 and 147: ACVR2 ASTE1 CASP5 MARCKS MBD4 MRE11
Page 148 and 149: DISCUSSIONColorectal cancer is a ve
Page 150 and 151: had mutation frequencies of 75% or
Page 152 and 153: Previous studies have shown that RC
Page 154 and 155:
REFERENCES1. Grady WM, Carethers JM
Page 156 and 157:
Studies on p53, BAX and Bcl-2 prote
Page 158 and 159:
Gene name Multiplex Annealing Numbe
Page 161:
Appendix I - List of abbreviations5
Page 164 and 165:
RØYRVIK ET AL.2plastic properties.
Page 166 and 167:
RØYRVIK ET AL.was, by reverse gene
Page 168 and 169:
RØYRVIK ET AL.the PubMed database;
Page 170 and 171:
RØYRVIK ET AL.TABLE I, continuedMu
Page 172 and 173:
RØYRVIK ET AL.TABLE I, continuedMu
Page 174 and 175:
RØYRVIK ET AL.gene must be validat
Page 176 and 177:
RØYRVIK ET AL.Another topic that d
Page 178 and 179:
RØYRVIK ET AL.22. Bodmer WF. Cance
Page 180 and 181:
RØYRVIK ET AL.lite instability in
Page 182 and 183:
RØYRVIK ET AL.Roche PC, Smith DI,
Page 184 and 185:
RØYRVIK ET AL.instability high (MS
Page 186 and 187:
RØYRVIK ET AL.112. Ionov Y, Matsui
Page 188 and 189:
RØYRVIK ET AL.133. Guanti G, Resta
Page 190 and 191:
RØYRVIK ET AL.155. Li YC, Korol AB
show all

Novel genetic and epigenetic alterations in ... - Ous-research.no

Create successful ePaper yourself

Delete template?

Save as template?