Mohammed T. Abou-Saleh

352Table 63.1 Clinical and structural correlates on CT in ADReference Mean age (or range) n CT measure Clinical features Association {36 70.0 43 Cortex GRD C=0.56Lateral ventricles C=0.6237 78.6 40 Cortex Age, paranoid delusions NS, C=70.65**Lateral ventricles Age, digit symbol test NS, C=70.31*Evan’s ratio Age, digit symbol test NS, C=70.31*38 NS 22 Lateral ventricles GRD, duration C=0.73**, NSSylvian fissures GRD, duration C=0.59*, NSSurface sulci GRD, duration NS, C=0.61**(a) Presenile 59.6 10 Cortex Age NS(b) Senile 77.6 740 53–87 59 Cortex GRD, age NS, C=0.27*Lateral ventricles GRD, age C=0.29*, C=0.50***, C=0.46***III ventricle GRD NSIV ventricle GRD41 77.0 57 Cortex Age, duration, cognition, AD NS, NS, NS, NSLateral ventricles Age, duration, cognition, AD NS, C=0.29*, C=70.35**, C=70.43***III ventricle Age, duration, cognition, AD NS, NS, C=70.40***, C=70.30**42 72.7 35 Lateral ventricles Age, GDS, MSQ C=0.55*, C=0.37*, C=0.42**32 58.1 8 Lateral ventricles Memory C=70.68**Lateral ventricles Verbal fluency C=70.59**Lateral ventricles Proverb interpretation C=0.74***Lateral ventricles Clock drawing C=0.60**43 78.1 47 Lateral ventricles Digit copying test, MTS C=0.24*, NSRegional density: pontine C=70.31***, C=0.40**44 60.7 60 Cortex Aphasia, GRD NS, NSLateral ventricles Aphasia, GRD *, *45 67.9 42 Cortex Memory, deterioration in IQ C+0.30*, NSLateral ventricles Memory, deterioration in IQ NS, NS46 45–84 39 Total intracranial CSF IMC, MMSE, BDS *, *, *47 72.2 16 Lateral ventricles MMSE C=70.46*31 63.4 30 Cortex Age, duration, MMSE, GDS NS, *, ***, ***Lateral ventricles Age, duration, MMSE, GDS NS, NS, NS, NSIII ventricle Age, duration, MMSE, GDS **, NS, **, ***17 79.7 138 Cortex Age, duration, MMSE, CAMCOG C=70.27***, C=0.24**, C=70.42***, C=70.41***Lateral ventricles Age, duration, MMSE, CAMCOG NS, NS, C=70.25**, C=70.31***III ventricle Age, duration, MMSE, CAMCOG NS, C=0.22**, C=70.31***, C=70.34***R Sylvian fissure Age, duration, MMSE, CAMCOG C=0.21**, NS, C=70.25**, C=70.27**L Sylvian fissure Age, duration, CAMCOG NS, NS, C=70.28***, C=70.30***48 79.7 138 Lateral ventricles Delusions ** (Smaller venticles)Basal ganglia calcification Delusions **Temporal atrophy Aggression *Frontal/occipital atrophy Hyperorality ***50 75.0 60 Brain quadrants Misidentification symptoms (MS) MS associated with larger right anterior horn of lateralventricles and left anterior brain areas51 75.0 60 III ventricle Age, duration, MMSE, CAMCOG NS, C=0.34**, C=70.23**, C=70.27**L anterior horn Age, duration, MMSE, CAMCOG NS, C=0.39***, C=70.33***, C=70.36***R anterior horn Age, duration, MMSE, CAMCOG NS, NS, C=70.25**, C=70.23**Subarachnoid areas:L frontal Age, duration, MMSE, CAMCOG NS, C=0.32**, NS, NSR frontal Age, duration, MMSE, CAMCOG NS, C=0.39**, NS, NSL posterior Age, duration, MMSE, CAMCOG NS, C=0.36**, NS, NSR posterior Age, duration, MMSE, CAMCOG NS, NS, NS, NS52 75.0 60 Total intracranial density Age, duration, MMSE, CAMCOG NS, NS, NS, NSGrey matter Age, duration, MMSE, CAMCOG NS, NS, NS, NSWhite matter Age, duration, MMSE, CAMCOG NS, C=0.32** ƒ , NS, NS{ Associations reflect the information in the original paper: NS, not significant; C, correlation coefficient (Spearman or Pearson), given if significant followed by significance level: *p50.05, **p50.01; ***p50.001.ƒ In L parietal only.GRD, Global rating of dementia (varies from study to study): GDS, Global Deterioration Scale: MSQ, Mental Status Questionnaire: MTS, Mental Test Score; MMSE, Mini-Mental State Examination; CAMCOG, part ofCamdex 53 ; IMC, Information memory and Concentration Test; BDS, Blessed Dementia Scale. Table reproduced from O’Brien, J., Ames, D., and Burns, A. (eds), Dementia, 2nd edn, 2000, by permission of Edward Arnold.