Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB

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Antibiotics, , PK in wards and ICUHydrophilicantibioticsLipophilic antibioticsGeneral PKLow VdPredominant renal ClLow intracellular penetrationHigh VdPredominant hepatic ClGood intracellularpenetrationAltered ICU PKIncreased VdCl higher or lowerdependent on renal functionVd largely unchangedCl higher or lowerdependent on hepaticfunctionExamplesBeta-lactamsAminoglycosidesGlycopeptidenLinezolidColisitinFluoroquinolonesMacrolidesLincoamidesTigecyclineRoberts. Crit Care Med;37:840-851851
SepsisIncreased CardiacOutputLeaky Capillaries&/oralteredprotein bindingNormal organfunctionEnd OrganDysfunction (e.g.renal or hepatic)Increased ClIncreased VdUnchanged VdDecreased ClLow plasmaconcentrationsNormal plasmaconcentrationsHigh plasmaconcentrationsRoberts. Crit Care Med;37:840-851851
Page 1 and 2: Antimicrobial Pharmacokinetics/dyna
Page 3 and 4: Inappropriate therapy and VAP morta
Page 5: Antibiotic dosing strategies in ren
Page 9 and 10: Continuous Renal Replacement Therap
Page 11 and 12: Basic principlesExtracorporeal clea
Page 13 and 14: Efficacy and PharmacodynamicsDrug l
Page 15 and 16: Use of ciprofloxacin in the critica
Page 17 and 18: Quinolones: AUC/MIC > 125AUC above
Page 19 and 20: AUC 1-241ciprofloxacin 2 x 400 mg I
Page 21 and 22: Simulated fractional attainment of
Page 23 and 24: β-lactam static effects: streptoco
Page 25 and 26: More antibiotic specific: T > MIC f
Page 27 and 28: Randomised, prospective, open singl
Page 29 and 30: Systematic review on clinical benef
Page 31 and 32: Total costs of intravenous antibiot
Page 33 and 34: The jury is still out on continuous
Page 35 and 36: Pk during CVVH various antibiotics3
Page 37 and 38: Risk of underdosingHydrophylic anti
Page 39: Thank you!Arthur van Zantenzantena@

Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB

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