Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB

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<strong>Antimicrobial</strong> Pk/Pd: <strong>Bedside</strong> Applications inthe Critically Ill with Renal FailureIn many infections in ICU patients higher ciprofloxacin dosagesshould be used even in renal failure or alternative antibiotics shouldbe consideredTherapeutic drug monitoring may be used to optimize antibiotictherapyTDM during continuous infusion does require fewer serum samplesDuring therapeutic hypothermia cefotaxime levels are 2 times highercompared to normothermiaICU Pk/Pd data are scarceDuring CVVH: calculate maintenance dose multiplication factor orTDMClinical failure could be due to underdosingTDM maybe also for non-toxic antibioticsKnow or measure MICs for common pathogens in hospital ICUFor nontoxic antibiotics overdosing is preferable to underdosing
Thank you!Arthur van Zantenzantena@zgv.nl
Page 1 and 2: Antimicrobial Pharmacokinetics/dyna
Page 3 and 4: Inappropriate therapy and VAP morta
Page 5 and 6: Antibiotic dosing strategies in ren
Page 7 and 8: SepsisIncreased CardiacOutputLeaky
Page 9 and 10: Continuous Renal Replacement Therap
Page 11 and 12: Basic principlesExtracorporeal clea
Page 13 and 14: Efficacy and PharmacodynamicsDrug l
Page 15 and 16: Use of ciprofloxacin in the critica
Page 17 and 18: Quinolones: AUC/MIC > 125AUC above
Page 19 and 20: AUC 1-241ciprofloxacin 2 x 400 mg I
Page 21 and 22: Simulated fractional attainment of
Page 23 and 24: β-lactam static effects: streptoco
Page 25 and 26: More antibiotic specific: T > MIC f
Page 27 and 28: Randomised, prospective, open singl
Page 29 and 30: Systematic review on clinical benef
Page 31 and 32: Total costs of intravenous antibiot
Page 33 and 34: The jury is still out on continuous
Page 35 and 36: Pk during CVVH various antibiotics3
Page 37: Risk of underdosingHydrophylic anti

Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB

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