Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB

Systematic review on clinical benefits of continuousadministration of beta-lactan antibioticsSystematic review 14 RCTs (from 59 studies)No difference in clinical cure rateNo difference in mortalityAll studies except one used higher dosages in the bolusgroup potentially favouring this treatment armThe limited data available suggest that CI leads to the sameclinical results as higher dosed bolus administration inhospitalized patientsRoberts, Lipmans et al Crit Care Med 2009; 37:2071-2078