Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB

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Ways to prolong duration of β-lactamconcentrations over MIC1. Use another drug (eg, probenecid) that interferes with itselimination.2. Dose frequently.3. Increase the dose of the antibiotic.4. Replace it with another therapeutically equivalent antibioticwith a longer serum half-life (T 1/2 ).5. Administer it by constant infusion.Quintiliani Infect Med 21(5):219-233, 233, 2004
Randomised, prospective, open single centre study in 93 COPDpatientssuspected or proven pulmonary infection: cefotaximecontinuous infusion: 1 gr loading dose iv, 2 gr/24 hr vs.intermittent infusion: 3 x 1 gr = equivalentMore optimal drug levels at the end of dosing interval duringcontinuous infusion
Page 1 and 2: Antimicrobial Pharmacokinetics/dyna
Page 3 and 4: Inappropriate therapy and VAP morta
Page 5 and 6: Antibiotic dosing strategies in ren
Page 7 and 8: SepsisIncreased CardiacOutputLeaky
Page 9 and 10: Continuous Renal Replacement Therap
Page 11 and 12: Basic principlesExtracorporeal clea
Page 13 and 14: Efficacy and PharmacodynamicsDrug l
Page 15 and 16: Use of ciprofloxacin in the critica
Page 17 and 18: Quinolones: AUC/MIC > 125AUC above
Page 19 and 20: AUC 1-241ciprofloxacin 2 x 400 mg I
Page 21 and 22: Simulated fractional attainment of
Page 23 and 24: β-lactam static effects: streptoco
Page 25: More antibiotic specific: T > MIC f
Page 29 and 30: Systematic review on clinical benef
Page 31 and 32: Total costs of intravenous antibiot
Page 33 and 34: The jury is still out on continuous
Page 35 and 36: Pk during CVVH various antibiotics3
Page 37 and 38: Risk of underdosingHydrophylic anti
Page 39: Thank you!Arthur van Zantenzantena@

Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB

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