Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB

Loading doseMainly depends on Vd, not eliminationReflection of volume to dissolve drugNo adjustment in renal failure or CVVHVd affected by:◦ Total body water◦ Tissue perfusion◦ Protein binding◦ Lipid solubility◦ pH gradients◦ Active transport mechanismsIncreased loading dose may be required in critically illBouman. Curr Opin Crit Care;14:654-659659