Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB
Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB
Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB
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Basic principlesExtracorporeal clearance (Cl EC ) is usually considered clinicallysignificant only if its contribution to total body clearanceexceeds 25 - 30%Fr EC =Cl ECCl EC + Cl R + Cl NRNot relevant for drugs with high non-renal clearanceOnly drug not bound to plasma proteins can be removed byextracorporeal procedures (unbound protein of a drug Fup)Schetz. Curr Opin crit Care 2007;13:645-5151