Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB

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Convective Elimination during CVVHBlood flow outCl CVVH= SC XCl CVVHQ UFmembraneSieving Coefficient (SC)SC =[UF][Blood]HemofilterBloodUltrafiltrateBlood flow in
Basic principlesExtracorporeal clearance (Cl EC ) is usually considered clinicallysignificant only if its contribution to total body clearanceexceeds 25 - 30%Fr EC =Cl ECCl EC + Cl R + Cl NRNot relevant for drugs with high non-renal clearanceOnly drug not bound to plasma proteins can be removed byextracorporeal procedures (unbound protein of a drug Fup)Schetz. Curr Opin crit Care 2007;13:645-5151
Page 1 and 2: Antimicrobial Pharmacokinetics/dyna
Page 3 and 4: Inappropriate therapy and VAP morta
Page 5 and 6: Antibiotic dosing strategies in ren
Page 7 and 8: SepsisIncreased CardiacOutputLeaky
Page 9: Continuous Renal Replacement Therap
Page 13 and 14: Efficacy and PharmacodynamicsDrug l
Page 15 and 16: Use of ciprofloxacin in the critica
Page 17 and 18: Quinolones: AUC/MIC > 125AUC above
Page 19 and 20: AUC 1-241ciprofloxacin 2 x 400 mg I
Page 21 and 22: Simulated fractional attainment of
Page 23 and 24: β-lactam static effects: streptoco
Page 25 and 26: More antibiotic specific: T > MIC f
Page 27 and 28: Randomised, prospective, open singl
Page 29 and 30: Systematic review on clinical benef
Page 31 and 32: Total costs of intravenous antibiot
Page 33 and 34: The jury is still out on continuous
Page 35 and 36: Pk during CVVH various antibiotics3
Page 37 and 38: Risk of underdosingHydrophylic anti
Page 39: Thank you!Arthur van Zantenzantena@

Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB

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