Pre-Exposure Prophylaxis PrEP

ARV Regimens for HIV PEP• Raltegravir is well tolerated, has few d-d interactions,achieves higher concentrations in male and femalegenital tract t than do PIs and efavirenz• Atazanavir and Darunavir are well tolerated ,cause lesslipid abnormalities than Lopinavir/ritonavir, and each issingle daily dosing.• If selected, Atazanavir and Darunavir should be given withritonavir, which boosts the serum levels of the parent drug.• Maraviroc is of interest, since new infection involves CCR5tropic virus exclusively. However, experience with this drugis still limited recommended at the current timeElse LJ. Antivir Ther 2011; 16:1149.Méchai F. J Med Virol 2008; 80:9.