Pre-Exposure Prophylaxis PrEP

Indications for Occupational PEP*Source HIV status Type of exposure Type of body fluid PEPPositiveUnknown withhigh risk for HIVinfection (eg.,IVDU)Unknown withlow risk for HIVinfectionNot availablePercutaneous,mucous membrane,non-intact skinPercutaneous,mucous membrane,non-intact skinPercutaneous,mucous membrane,non-intact skinPercutaneous,mucous membrane,non-intact skinDefinitely orpotentially InfectiousDefinitely orpotentially InfectiousDefinitely orpotentially InfectiousDefinitely orpotentially InfectiousOfferOffer and awaitingHIV testingDelay whileawaiting rapidHIV testing(result is availablewithin 2 hours)Not recommend***In all cases, the decision to administer PEP must weigh the risk of infection with HIV against the toxicity andinconvenience of PEP. The individual preferences of the exposed HCP will generally determine the decision about whether toproceed with PEP.**unless it occurred in a setting where exposure to HIV is likely (eg, a needlestick from a sharps container in an HIV clinic).Bartlett JG. Management of healthcare personnel exposed to HIV. UpToDate. July 2012http://www.uptodate.com/home/clinicians/index.html