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in pathology.<br />

26. 4.1.1.3. Animal<br />

mo<strong>de</strong>ls for the<br />

study of<br />

<strong>de</strong>generative<br />

chronic diseases<br />

(cancer, obesity,<br />

diabetis mellitus,<br />

cardiovascular<br />

diseases).<br />

4.1.6.2. Study of<br />

the mammary<br />

tumors:<br />

vasculogenic<br />

mimicry in<br />

mammary<br />

carcinomas.<br />

4.1.5.1. I<strong>de</strong>ntifying<br />

the new<br />

therapeutic<br />

opportunities based<br />

on natural<br />

compound in the<br />

treatment of<br />

chronic<br />

<strong>de</strong>generative<br />

diseases<br />

27. 4.1.3.10.<br />

I<strong>de</strong>ntification,<br />

isolation and<br />

characte-rization of<br />

molecular<br />

biomarkers with<br />

diagnostic and<br />

prognostic value in<br />

animal pathology<br />

4.1.6.1. The role of<br />

the inflammation<br />

and endothelial<br />

progenitor cells in<br />

the<br />

neovasculatisation<br />

of adipose tissue in<br />

obesity<br />

Research Center:<br />

Comparative and<br />

Experimental<br />

Pathology<br />

Director: Prof. Cornel<br />

Cătoi<br />

Research Laboratory:<br />

Laboratory of<br />

Veterinary Medical<br />

Diagnosis<br />

Director: Prof.<br />

Marina Spanu<br />

- Investigation of transmission,<br />

pathogenicity and phytotherapy<br />

of the infections with prototheca<br />

in humans and animals; Director<br />

Project Bouari (Cuc) 2010-2012,<br />

Contract CNCSIS tip, PD, nr.175,<br />

Cosmina Boari Cuc.<br />

- Study of mammary tumors:<br />

vasculogenic mimicry in dogs<br />

mammary tumors, tumor stem<br />

cells - a new hypothesis mo<strong>de</strong>l of<br />

tumorigenesis, the implication of<br />

oxidative stress in Breast chemical<br />

carcinogenesis; Grant CNCSIS, cod.<br />

364<br />

Obtaining and characterization of<br />

new targeted-nanodrugs with<br />

naphtoquinonic active substance<br />

(NANOQMED). PNCDI II.Grant nr.<br />

61-002/2007 (2007-2010<br />

- Full achieve and extracts<br />

fractionated with high<br />

bioavailability and adjuvant<br />

potential for economic interest<br />

species; Proiect CEEX<br />

- Antibacterial character and<br />

stimulating regeneration tissue of<br />

biomaterials,phosphate; PN II I<strong>de</strong>i<br />

simple<br />

- The study of the influence of<br />

housing and practices<br />

management on the welfare of<br />

dairy cows; PN II, I<strong>de</strong>i simple<br />

- Fundamental and applied<br />

studies of epi<strong>de</strong>miology, biology<br />

and molecular genetics of vector<br />

Bouari (Cuc) M. C., N. Fiţ, S. Răpuntean, G.<br />

Nadăş, A. Gal, P. Bolfă, M. Taulescu, C.<br />

Cătoi, (2011),In vitro <strong>evaluation</strong> of the<br />

antimicrobial properties of some plant<br />

essential oils against clinical isolates of<br />

Prototheca spp., Romanian<br />

Biotechnological Leters, Vol.16, nr.3,<br />

6146-6152.<br />

Adrian F. Gal, Alecsandru I. Baba,<br />

ViorelMiclaus, Adriana Titilincu,<br />

CosminaCuc, Marian Taulescu, Cornel<br />

Catoi, (2011), Aspects regarding<br />

intratumor angiogenesis and vasculogenic<br />

mimicry in canine mammary tumors.,<br />

RevistaRomană <strong>de</strong> Medicină <strong>de</strong> Laborator,<br />

Vol. 19, Nr 3/4 :289-303.<br />

MARCUS I, IULIA PRODAN, SEVASTRE B,<br />

SARPATAKI O, MANALACHIOAIE R,<br />

TAMAIAN R, 2011, In vivo testing of the<br />

biological effects of new synthesized 2cloro-3-nicotinamido<br />

-1,4 – naphtoquinone<br />

(CNNQ) and 2-mercapto-3-nicotinamido<br />

-1,4-naphtoquinone (MNNQ),<br />

International Conference of Animal<br />

Pathophysiology, St. Petersburg State<br />

Aca<strong>de</strong>my of Vet Med, Russia, 139-141<br />

Immune response to fleas in a wild <strong>de</strong>sert<br />

ro<strong>de</strong>nt: effect of parasite species, parasite<br />

bur<strong>de</strong>n, sex of host and host<br />

parasitological experience, Khokhlova IS;<br />

Spinu M; Krasnov BR; et al., 2004,<br />

JOURNAL OF EXPERIMENTAL<br />

BIOLOGY Vol: 207 Issue: 16 Pages:<br />

2725-2733 DOI: 10.1242/jeb.01090<br />

- Human type M. tuberculosis expresses<br />

increased immune-pathogenic effects in<br />

Guinea pigs after corticosteroid<br />

treatment,<br />

Spînu Marina, Pop Carmen Monica,<br />

Brudaşcă F., Anca Opriş, Şandru Carmen –<br />

2003, European Respiratory Journal,<br />

vol.22, supplement 45, p.397<br />

- Evaluation of diagnostic value of<br />

USAMV CN<br />

UMF CN<br />

IO CN<br />

ICSI R. Valcea<br />

USAMV CN<br />

PLANTA MEDICA<br />

Appendix – Research topics<br />

Patent<br />

Application<br />

(CBI) A/01250<br />

dated<br />

30.11.2010<br />

Protocol(techni<br />

que) of<br />

administration<br />

of a <strong>de</strong>rivative<br />

naftalendionic<br />

used in the<br />

control of the<br />

tumor growth<br />

Patent<br />

Application<br />

(CBI) A/01251<br />

dated<br />

30.11.2010<br />

Derived<br />

naftalen-dionic<br />

used in the<br />

control of the<br />

tumor growth.<br />

Page 85 SELF-EVALUATION REPORT, March, 2012

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