Verteporfin photodynamic therapy for neovascular age-related ...

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40 Results (1) – study cohortTABLE 6 Baseline characteristics of eligible patients (column percentages within characteristic unless otherwise stated)Patient characteristicNumber of patients first treated> 350 days before the end of the studyNumber of patients first treated≤ 350 days before the end of the studyTotal eligible patients 4566 1655 6221(see Figure 3)GenderMale 1893 (41.5%) 689 (41.6%) 2582 (41.5%)Female 2658 (58.2%) 962 (58.1%) 3620 (58.2%)Missing 15 (0.3%) 4 (0.2%) 19 (0.3%)Age (years)Median 78 79 78Interquartile range 72–83 73–84 72–83Range 8–102 14–102 8–102Age group< 50 years 203 (4.6%) 61 (3.7%) 264 (4.2%)≥ 50 to < 65 years 345 (7.6%) 120 (7.3%) 465 (7.5%)≥ 65 to < 75 years 993 (21.7%) 319 (19.3%) 1312 (21.1%)≥ 75 to < 85 years 2180 (47.7%) 805 (48.6%) 2985 (48.0%)≥ 85 years 845 (18.5%) 350 (21.1%) 1195 (19.2%)Smoking historyUnknown 775 (17.0%) 164 (9.9%) 939 (15.1%)Current smoker 617 (13.5%) 215 (13.0%) 832 (13.4%)Ex-smoker 1543 (33.8%) 549 (33.2%) 2092 (33.6%)Never smoked 1631 (35.7%) 727 (43.9%) 2358 (37.9%)TotalThe baseline characteristics of this subset of patients and eyes are shown in Table 9, which breaksdown the data according to whether patients/eyes were classified as EFT, IFT or UNC. In the EFTgroup, predominantly classic CNV was present in 86.7% (1064/1227) and minimally classic in13.3% (163/1227). In the IFT group, predominantly classic CNV was present in 52.9% (628/1187)and minimally classic in 47.1% (559/187). The mean baseline logMAR BCVA was 50 letters(20/100) in the treated eye, which was very similar to study eyes of patients randomised in theTAP trials (53 letters). 3
DOI: 10.3310/hta16060Health Technology Assessment 2012; Vol. 16: No. 641TABLE 7 Baseline characteristics of eligible eyes (column percentages within characteristic unless otherwise stated)Visual function measureNumber of eyes first treated> 350 days before the end of the studyNumber of eyes ≤ 350 days before theend of the studyTotalTotal eligible eyes (see Figure 3) 4919 1728 6647Visual acuity at baseline (first treatment visit)Mean BCVA (SD) 50.4 (16.0) 50.6 (15.5) 50.4 (15.9)Median (interquartile range) 51 (39–62) 51 (40–62) 51 (40–62)Number of ETDRS letters read> 73 356 (7.2%) 122 (7.1%) 478> 53 to ≤ 73 1838 (37.4%) 640 (37.0%) 2478> 33 to ≤ 53 2089 (42.5%) 767 (44.4%) 2856≤ 33 626 (12.7%) 195 (11.3%) 821CF, HM, PL, NPL 10 (0.2%) 2 (0.1%) 12Contrast sensitivityMean contrast sensitivity (SD) 22.8 (7.6) 22.4 (7.6) 22.7 (7.6)Median (interquartile range) 24 (18–28) 24 (18–28) 24 (18–48)Number of CS letters read0 45 (0.9%) 26 (1.5%) 71> 0 and ≤ 18 684 (13.9%) 224 (13.0%) 908> 18 and ≤ 24 828 (16.8%) 300 (7.2%) 1128> 24 and ≤ 28 580 (11.8%) 188 (17.4%) 768> 28 679 (7.2%) 210 (12.1%) 889Missing 2103 (13.8%) 780 (45.1%) 2883Evidence of prior laserphotocoagulation12 3 15CF, counting fingers; HM, hand movements; NPL,no perception of light; PL, perception of light.© Queen’s Printer and Controller of HMSO 2012. This work was produced by Reeves et al. under the terms of a commissioning contract issued by theSecretary of State for Health.
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90 Appendix 1THE VERTEPORFIN PHOTOD
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FeedbackThe HTA programme and the a
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