Verteporfin photodynamic therapy for neovascular age-related ...

More documents

Recommendations

Info

196 Health Technology Assessment programmeHTA Commissioning Board (continued)Professor Barney Reeves,Professorial Research Fellowin Health Services Research,Department of Clinical Science,University of BristolProfessor Martin Underwood,Professor of Primary CareResearch, Warwick MedicalSchool, University of WarwickProfessor Marion Walker,Professor in Stroke Rehabilitation,Associate Director UK StrokeResearch Network, University ofNottinghamDr Duncan Young,Senior Clinical Lecturer andConsultant, Nuffield Departmentof Anaesthetics, University ofOxfordObserversDr Tom Foulks,Medical Research CouncilDr Kay Pattison,Senior NIHR ProgrammeManager, Department of HealthHTA Clinical Evaluation and Trials BoardChair,Professor Sallie Lamb,Director,Warwick Clinical Trials Unit,Warwick Medical School,University of Warwick and Professor ofRehabilitation,Nuffield Department of Orthopaedic,Rheumatology and Musculoskeletal Sciences,University of OxfordDeputy Chair,Professor Jenny Hewison,Professor of the Psychology of Health Care,Leeds Institute of Health Sciences,University of LeedsProgramme Director,Professor Tom Walley, CBE,Director, NIHR HTA programme, Professor ofClinical Pharmacology, University of LiverpoolMembersProfessor Keith Abrams,Professor of Medical Statistics,Department of Health Sciences,University of LeicesterProfessor Martin Bland,Professor of Health Statistics,Department of Health Sciences,University of YorkProfessor Jane Blazeby,Professor of Surgery andConsultant Upper GI Surgeon,Department of Social Medicine,University of BristolProfessor Julia M Brown,Director, Clinical Trials ResearchUnit, University of LeedsProfessor Alistair Burns,Professor of Old Age Psychiatry,Psychiatry Research Group, Schoolof Community-Based Medicine,The University of Manchester &National Clinical Director forDementia, Department of HealthDr Jennifer Burr,Director, Centre for HealthcareRandomised trials (CHART),University of AberdeenProfessor Linda Davies,Professor of Health Economics,Health Sciences Research Group,University of ManchesterProfessor Simon Gilbody,Prof of Psych Medicine and HealthServices Research, Department ofHealth Sciences, University of YorkProfessor Steven Goodacre,Professor and Consultant inEmergency Medicine, School ofHealth and Related Research,University of SheffieldProfessor Dyfrig Hughes,Professor of Pharmacoeconomics,Centre for Economics and Policyin Health, Institute of Medicaland Social Care Research, BangorUniversityProfessor Paul Jones,Professor of Respiratory Medicine,Department of Cardiac andVascular Science, St George‘sHospital Medical School,University of LondonProfessor Khalid Khan,Professor of Women’s Health andClinical Epidemiology, Barts andthe London School of Medicine,Queen Mary, University of LondonProfessor Richard J McManus,Professor of Primary CareCardiovascular Research, PrimaryCare Clinical Sciences Building,University of BirminghamProfessor Helen Rodgers,Professor of Stroke Care, Institutefor Ageing and Health, NewcastleUniversityProfessor Ken Stein,Professor of Public Health,Peninsula Technology AssessmentGroup, Peninsula Collegeof Medicine and Dentistry,Universities of Exeter andPlymouthProfessor Jonathan Sterne,Professor of Medical Statisticsand Epidemiology, Departmentof Social Medicine, University ofBristolMr Andy Vail,Senior Lecturer, Health SciencesResearch Group, University ofManchesterProfessor Clare Wilkinson,Professor of General Practice andDirector of Research North WalesClinical School, Department ofPrimary Care and Public Health,Cardiff UniversityDr Ian B Wilkinson,Senior Lecturer and HonoraryConsultant, Clinical PharmacologyUnit, Department of Medicine,University of CambridgeObserversMs Kate Law,Director of Clinical Trials,Cancer Research UKDr Morven Roberts,Clinical Trials Manager, HealthServices and Public HealthServices Board, Medical ResearchCouncilCurrent and past membership details of all HTA programme ‘committees’ are available from the HTA website (www.hta.ac.uk)
DOI: 10.3310/hta16060Health Technology Assessment 2012; Vol. 16: No. 6197Diagnostic Technologies and Screening PanelMembersChair,Professor Lindsay WilsonTurnbull,Scientific Director of theCentre for Magnetic ResonanceInvestigations and YCR Professorof Radiology, Hull Royal InfirmaryProfessor Judith E Adams,Consultant Radiologist,Manchester Royal Infirmary,Central Manchester & ManchesterChildren’s University HospitalsNHS Trust, and Professor ofDiagnostic Radiology, Universityof ManchesterMr Angus S Arunkalaivanan,Honorary Senior Lecturer,University of Birmingham andConsultant Urogynaecologistand Obstetrician, City Hospital,BirminghamDr Diana Baralle,Consultant and Senior Lecturerin Clinical Genetics, University ofSouthamptonDr Stephanie Dancer,Consultant Microbiologist,Hairmyres Hospital, East KilbrideDr Diane Eccles,Professor of Cancer Genetics,Wessex Clinical Genetics Service,Princess Anne HospitalDr Trevor Friedman,Consultant Liason Psychiatrist,Brandon Unit, Leicester GeneralHospitalDr Ron Gray,Consultant, National PerinatalEpidemiology Unit, Institute ofHealth Sciences, University ofOxfordProfessor Paul D Griffiths,Professor of Radiology, AcademicUnit of Radiology, University ofSheffieldMr Martin Hooper,Public contributorProfessor Anthony RobertKendrick,Associate Dean for ClinicalResearch and Professor of PrimaryMedical Care, University ofSouthamptonDr Nicola Lennard,Senior Medical Officer, MHRADr Anne Mackie,Director of Programmes, UKNational Screening Committee,LondonMr David Mathew,Public contributorDr Michael Millar,Consultant Senior Lecturer inMicrobiology, Department ofPathology & Microbiology, Bartsand The London NHS Trust, RoyalLondon HospitalMrs Una Rennard,Public contributorDr Stuart Smellie,Consultant in Clinical Pathology,Bishop Auckland General HospitalMs Jane Smith,Consultant UltrasoundPractitioner, Leeds TeachingHospital NHS Trust, LeedsDr Allison Streetly,Programme Director, NHS SickleCell and Thalassaemia ScreeningProgramme, King’s College Schoolof MedicineDr Matthew Thompson,Senior Clinical Scientist and GP,Department of Primary HealthCare, University of OxfordDr Alan J Williams,Consultant Physician, General andRespiratory Medicine, The RoyalBournemouth HospitalObserversDr Tim Elliott,Team Leader, Cancer Screening,Department of HealthDr Joanna Jenkinson,Board Secretary, Neurosciencesand Mental Health Board(NMHB), Medical ResearchCouncilProfessor Julietta Patnick,Director, NHS Cancer ScreeningProgramme, SheffieldDr Kay Pattison,Senior NIHR ProgrammeManager, Department of HealthProfessor Tom Walley, CBE,Director, NIHR HTAprogramme, Professor of ClinicalPharmacology, University ofLiverpoolDr Ursula Wells,Principal Research Officer, PolicyResearch Programme, Departmentof HealthDisease Prevention PanelMembersChair,Professor Margaret Thorogood,Professor of Epidemiology,University of Warwick MedicalSchool, CoventryDr Robert Cook,Clinical Programmes Director,Bazian Ltd, LondonDr Colin Greaves,Senior Research Fellow, PeninsulaMedical School (Primary Care)Mr Michael Head,Public contributorObserversProfessor Cathy Jackson,Professor of Primary CareMedicine, Bute Medical School,University of St AndrewsDr Russell Jago,Senior Lecturer in Exercise,Nutrition and Health, Centrefor Sport, Exercise and Health,University of BristolDr Julie Mytton,Consultant in Child Public Health,NHS BristolProfessor Irwin Nazareth,Professor of Primary Care andDirector, Department of PrimaryCare and Population Sciences,University College LondonDr Richard Richards,Assistant Director of PublicHealth, Derbyshire CountyPrimary Care TrustProfessor Ian Roberts,Professor of Epidemiology andPublic Health, London School ofHygiene & Tropical MedicineDr Kenneth Robertson,Consultant Paediatrician, RoyalHospital for Sick Children,GlasgowDr Catherine Swann,Associate Director, Centre forPublic Health Excellence, NICEMrs Jean Thurston,Public contributorProfessor David Weller,Head, School of Clinical Scienceand Community Health,University of EdinburghMs Christine McGuire,Research & Development,Department of HealthDr Kay Pattison,Senior NIHR ProgrammeManager, Department of HealthProfessor Tom Walley, CBE,Director, NIHR HTAprogramme, Professor of ClinicalPharmacology, University ofLiverpool© Queen’s Printer and Controller of HMSO 2012. This work was produced by Reeves et al. under the terms of a commissioning contract issued by theSecretary of State for Health.
Page 5 and 6:
DOI: 10.3310/hta16060Health Technol
Page 12 and 13:
xExecutive summaryretreat on criter
Page 14 and 15:
xiiExecutive summaryof data, with i
Page 16 and 17:
2 Introductionon-going or new clini
Page 18 and 19:
4 Introductionof VPDT in routine cl
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31:
Page 34 and 35:
20 Key changes to the protocolThese
Page 36 and 37:
22 Key changes to the protocolCentr
Page 38 and 39:
24 Key changes to the protocolADVER
Page 40 and 41:
26 Key changes to the protocolPlan
Page 42 and 43:
28 Key changes to the protocolClass
Page 44 and 45:
30 Key changes to the protocolFor i
Page 46 and 47:
32 Key changes to the protocolIn ad
Page 48 and 49:
34 Key changes to the protocolsites
Page 52 and 53:
38 Results (1) - study cohortTABLE
Page 54 and 55:
Page 56 and 57:
Page 58 and 59:
Page 60 and 61:
46 Results (2) - objectives A, B, C
Page 62 and 63:
Page 64 and 65:
Page 66 and 67:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77:
Page 80 and 81:
66 Discussion of resultsStrengths a
Page 82 and 83:
68 Discussion of resultsThe VPDT st
Page 84 and 85:
70 Discussion of resultsOur analyse
Page 86 and 87:
72 Discussion of resultsA further c
Page 88 and 89:
74 Discussion of resultsVPDT. It is
Page 91 and 92:
Page 93 and 94:
Page 95:
Page 98 and 99:
84 References16. Stelmack J. Qualit
Page 100 and 101:
86 References49. Guymer RH, Chiu AW
Page 102 and 103:
88 References83. Margrain TH. Minim
Page 104 and 105:
90 Appendix 1THE VERTEPORFIN PHOTOD
Page 106 and 107:
92 Appendix 11. Overview of Manual
Page 108 and 109:
94 Appendix 1And, if also collectin
Page 110 and 111:
96 Appendix 1more patients in the v
Page 112 and 113:
98 Appendix 12.4 Limitations of the
Page 114 and 115:
100 Appendix 1Box 2 Key advantages
Page 116 and 117:
102 Appendix 14. Study population4.
Page 118 and 119:
104 Appendix 15. Recruitment to the
Page 120 and 121:
106 Appendix 16. Background data co
Page 122 and 123:
108 Appendix 1Table 1: Schedule of
Page 124 and 125:
110 Appendix 1The Verteporfin Photo
Page 126 and 127:
112 Appendix 1• Additional clinic
Page 128 and 129:
114 Appendix 18. Recording adverse
Page 130 and 131:
116 Appendix 1level of benefit from
Page 132 and 133:
118 Appendix 1• comparison of num
Page 134 and 135:
120 Appendix 110.6 Sub-group analys
Page 136 and 137:
122 Appendix 112. Data issues12.1 D
Page 138 and 139:
124 Appendix 113. Organisation13.1
Page 140 and 141:
126 Appendix 114. References[1] Ref
Page 142 and 143:
128 Appendix 1Barnes RM, Gee L, Tay
Page 144 and 145:
130 Appendix 1Appendix 1: Classifyi
Page 146 and 147:
132 Appendix 1Liverpool re-treatmen
Page 148 and 149:
134 Appendix 1Service StructurePlea
Page 150 and 151:
136 Appendix 1Has your photographer
Page 152 and 153:
138 Appendix 1There are many differ
Page 154 and 155:
140 Appendix 1testing on vision tes
Page 156 and 157:
142 Appendix 1something to do with
Page 158 and 159:
144 Appendix 1College of Ophthalmol
Page 160 and 161: 146 Appendix 1Appendix 5:Protocol f
Page 162 and 163: 148 Appendix 16.2 Subjective Refrac
Page 164 and 165: 150 Appendix 1• The patient shoul
Page 166 and 167: 152 Appendix 1Appendix 6:Protocol f
Page 168 and 169: 154 Appendix 18. It is customary to
Page 170 and 171: 156 Appendix 1Early or Transit Phas
Page 172 and 173: 158 Appendix 1
Page 174 and 175: 160 Appendix 1---------------------
Page 180 and 181: 166 Appendix 1Appendix 9:Site imple
Page 182 and 183: 168 Appendix 1Option 2 - units inte
Page 184 and 185: 170 Appendix 1Dos and Don’tsDosDo
Page 186 and 187: 172 Appendix 1Resource use question
Page 188 and 189: 174 Appendix 1Appendix 11: Recommen
Page 190 and 191: 176 Appendix 1ADVERSE REACTION AND
Page 192 and 193: 178 Appendix 1acute Trust; note tha
Page 194 and 195: 180 Appendix 1Ophthalmologistrespon
Page 197 and 198: DOI: 10.3310/hta16060Health Technol
Page 203: DOI: 10.3310/hta16060Health Technol
Page 206 and 207: 192 Appendix 3manufacturer’s pers
Page 209: DOI: 10.3310/hta16060Health Technol
Page 216: FeedbackThe HTA programme and the a
show all

Verteporfin photodynamic therapy for neovascular age-related ...

Create successful ePaper yourself

Delete template?

Save as template?