Verteporfin photodynamic therapy for neovascular age-related ...

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156 Appendix 1Early or Transit Phase4. The 1st photograph of F2 of the index eye is taken at the start of theinjection and the 2nd at the end of the injection. The purpose of this is todocument the time taken to inject the dye.5. 15-30 sec (F2 index eye) : - Take a rapid series of about 10-16 exposures atintervals of about 1 to 2 seconds.Mid Phase6. 30 - 45 seconds :- F2 and F1 of the index eye7. 50 seconds - 1 min :- F2 and F1 of the fellow eye8. 2 min : - F2 of the index and fellow eye9. 2½-3 min : - F2 of index eyeLate Phase10. 5 min : - F2 of index eye and fellow eye11. 10 min : - F2 of index eye and fellow-eyeUsing the appropriate software, the entire angiogram should be copied to a studydrive on the system. This is simply a partition of the main hard drive. As theseimages are a copy of those already on the main hard drive, the patients ID number,and name can be modified to protect their identity before the CD is burned. Only CD-Rs (not CD-RWs, re-writable discs) must be used.Digital files must include the following information about each patient:• Centre ID• Hospital number• Date of birth• Date of angiogramUsing CD burning software such as “Easy CD Creator” or “Gear Pro” burn the CDand label it with the patients study ID.
DOI: 10.3310/hta16060Health Technology Assessment 2012; Vol. 16: No. 61574. Film Fluorescein AngiographyFluorescein angiography may be captured on film if digital facilities are not available.• The recommended film is Kodak T-Max or Ilford 400 speed film.• The film may be processed by clinic staff or at a local processing laboratory.• The use of Kodak D-11, or similar developer, is recommended.• Any processing procedure that produces good quality negatives may be used.• Proper care should be taken to adequately fix the film to insure archivalstability.The timing for analogue fluorescein procedures is the same as for digital.Although it is customary to take the left member of a stereo pair first, when shootingwith film you must take the right side first.5. Mounting and Labelling of colour slidesAfter the slides are returned from the processing lab they must be sorted into theirstereo sets and each correctly labelled, with the centre and patient IDs. The labelledslides are then placed into transparent plastic sheets in the correct order for eacheye (see diagram below). Use one sheet for each eye. An identification label iscompleted and attached to the front of each plastic sheet.• The original negatives are cut into strips of six images per strip and are placedin a transparent plastic sheet with six strips per sheet (see diagram below).• A page identification label is attached to each page of negatives.• When cutting the film into strips, the photographer should take care not toseparate the members of a stereo pair.• Clinical centres should retain a copy of the angiogram by making a duplicateof the original negatives.As for digital files, films must include the following information about each patient:• Centre ID• Hospital number• Date of birth• Date of angiogram© Queen’s Printer and Controller of HMSO 2012. This work was produced by Reeves et al. under the terms of a commissioning contract issued by theSecretary of State for Health.
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xExecutive summaryretreat on criter
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xiiExecutive summaryof data, with i
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2 Introductionon-going or new clini
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4 Introductionof VPDT in routine cl
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20 Key changes to the protocolThese
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24 Key changes to the protocolADVER
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26 Key changes to the protocolPlan
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28 Key changes to the protocolClass
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30 Key changes to the protocolFor i
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34 Key changes to the protocolsites
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38 Results (1) - study cohortTABLE
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46 Results (2) - objectives A, B, C
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66 Discussion of resultsStrengths a
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68 Discussion of resultsThe VPDT st
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70 Discussion of resultsOur analyse
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72 Discussion of resultsA further c
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74 Discussion of resultsVPDT. It is
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84 References16. Stelmack J. Qualit
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86 References49. Guymer RH, Chiu AW
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88 References83. Margrain TH. Minim
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90 Appendix 1THE VERTEPORFIN PHOTOD
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92 Appendix 11. Overview of Manual
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94 Appendix 1And, if also collectin
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96 Appendix 1more patients in the v
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98 Appendix 12.4 Limitations of the
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100 Appendix 1Box 2 Key advantages
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102 Appendix 14. Study population4.
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104 Appendix 15. Recruitment to the
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Page 122 and 123: 108 Appendix 1Table 1: Schedule of
Page 124 and 125: 110 Appendix 1The Verteporfin Photo
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Page 130 and 131: 116 Appendix 1level of benefit from
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Page 158 and 159: 144 Appendix 1College of Ophthalmol
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