Verteporfin photodynamic therapy for neovascular age-related ...

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124 Appendix 113. Organisation13.1 Steering Committee and other key personnelThe Steering Committee consists of the individuals listed in Table 2.Table 2: Members of the Steering CommitteeChairDeputy Chair, and representative of theRCOphth Scientific CommitteeRetina specialistsEditor, Cochrane Eyes and VisionCollaborative Review GroupPublic Health ConsultantIndependent Scientific AdvisorData Management Centre representativeMr N AstburyMr D WongProfessor A Bird,Professor U Chakravarthy,Mr S Harding,Mr B Dhillon,Mr Y YangMr R WormaldDr D AustinProfessor A FletcherDr B ReevesNCCHTA representative Professor K Woods (until 31/10/03),Dr P Davidson (from 01/11/03)Consumer representativeMr T BremridgeDepartment of Health representative Mr D BusbyNovartis representative Mr N Gwatkin (until 29/02/04),Ms J Potts (from 01/03/04)Representative for Local Specialist Mr Peter GrahamCommissioners13.2 Data safety and monitoringThe Steering Committee has taken responsibility for data and safety monitoring. TheData Management Centre has responsibility for regular submission of a core set ofsummary descriptive data for review by the Committee. The details of thesesummary statistics have not yet been finalised, but will include all reports of adverseevents, recruitment rates overall and by DP, and details of treatments given by CNVcategory.
DOI: 10.3310/hta16060Health Technology Assessment 2012; Vol. 16: No. 612513.3 Central Angiographic Resource FacilityProfessor U Chakravarthy has responsibility for the Central Angiographic ResourceFacility (CARF) at Queen’s University, Belfast. All angiograms from DPs must besubmitted to the CARF, which will then digitise angiograms submitted on film anddistribute digital images between the three Angiogram Reading Centres (Belfast,Moorfields and Liverpool) in accordance with their capacity and current workloads.The submission, distribution and assessment of angiograms will be supported bysoftware designed for the study by Digital Health Care, Cambridge.13.4 Contact detailsData Management Centre:Dr Barney ReevesMs Sonia DhimanMiss Julia LanghamMs Annette CroucherLSHTM, Keppel Street,London WC1E 7HTE-mail address for databarney.reeves@lshtm.ac.ukparminder.dhiman@lshtm.ac.ukJulia.langham@lshtm.ac.ukannette.croucher@lshtm.ac.ukVPDT@lshtm.ac.ukCentral Angiographic Resource Facility (CARF):Alison Murphy; Nicola Duff;Liam PattersonOphthalmic ResearchCentre, Queen's Universityof Belfast, Royal VictoriaHospital, Belfast BT12 6BJCARF@qub.ac.ukDatabase support:Mr John FullartonStrategenMr Ian Kearyjohnrfullarton@aol.comian.keary@strategen.co.ukChief Investigator:Professor U ChakravarthyDept Ophthalmology,Queen's University ofBelfast, Royal VictoriaHospital, Belfast BT12 6BJu.chakravarthy@qub.ac.ukSee above for CARF© Queen’s Printer and Controller of HMSO 2012. This work was produced by Reeves et al. under the terms of a commissioning contract issued by theSecretary of State for Health.
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DOI: 10.3310/hta16060Health Technol
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xExecutive summaryretreat on criter
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xiiExecutive summaryof data, with i
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2 Introductionon-going or new clini
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4 Introductionof VPDT in routine cl
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20 Key changes to the protocolThese
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24 Key changes to the protocolADVER
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26 Key changes to the protocolPlan
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28 Key changes to the protocolClass
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30 Key changes to the protocolFor i
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38 Results (1) - study cohortTABLE
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46 Results (2) - objectives A, B, C
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66 Discussion of resultsStrengths a
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68 Discussion of resultsThe VPDT st
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70 Discussion of resultsOur analyse
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72 Discussion of resultsA further c
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Page 98 and 99: 84 References16. Stelmack J. Qualit
Page 100 and 101: 86 References49. Guymer RH, Chiu AW
Page 102 and 103: 88 References83. Margrain TH. Minim
Page 104 and 105: 90 Appendix 1THE VERTEPORFIN PHOTOD
Page 106 and 107: 92 Appendix 11. Overview of Manual
Page 108 and 109: 94 Appendix 1And, if also collectin
Page 110 and 111: 96 Appendix 1more patients in the v
Page 112 and 113: 98 Appendix 12.4 Limitations of the
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Page 116 and 117: 102 Appendix 14. Study population4.
Page 118 and 119: 104 Appendix 15. Recruitment to the
Page 120 and 121: 106 Appendix 16. Background data co
Page 122 and 123: 108 Appendix 1Table 1: Schedule of
Page 124 and 125: 110 Appendix 1The Verteporfin Photo
Page 126 and 127: 112 Appendix 1• Additional clinic
Page 128 and 129: 114 Appendix 18. Recording adverse
Page 130 and 131: 116 Appendix 1level of benefit from
Page 132 and 133: 118 Appendix 1• comparison of num
Page 134 and 135: 120 Appendix 110.6 Sub-group analys
Page 136 and 137: 122 Appendix 112. Data issues12.1 D
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Page 142 and 143: 128 Appendix 1Barnes RM, Gee L, Tay
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Page 146 and 147: 132 Appendix 1Liverpool re-treatmen
Page 148 and 149: 134 Appendix 1Service StructurePlea
Page 150 and 151: 136 Appendix 1Has your photographer
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Page 156 and 157: 142 Appendix 1something to do with
Page 158 and 159: 144 Appendix 1College of Ophthalmol
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174 Appendix 1Appendix 11: Recommen
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176 Appendix 1ADVERSE REACTION AND
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178 Appendix 1acute Trust; note tha
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180 Appendix 1Ophthalmologistrespon
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192 Appendix 3manufacturer’s pers
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FeedbackThe HTA programme and the a
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