Verteporfin photodynamic therapy for neovascular age-related ...

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90 Appendix 1THE VERTEPORFIN PHOTODYNAMIC THERAPY COHORTSTUDY FOR THE UNITED KINGDOMManual of OperationsVersion 2.123 December 2005Principal Investigators:Professor Usha Chakravarthy, Queen’s University BelfastMr Simon Harding, St Paul’s Eye Unit, LiverpoolDr Barnaby Reeves, London School of Hygiene and Tropical MedicineOn behalf of the Royal College of Ophthalmologists, London
DOI: 10.3310/hta16060Health Technology Assessment 2012; Vol. 16: No. 691LIST OF ABBREVIATIONSAMDCARFCNVCSDPBDVAETDRSFADGLDGPlogMARLRECLSCGMDVAMRECNEIVFQNICENCCHTAPCTPDTQoLRCOphthSDSF-36SFRADSSRVFTAP studyVIP studyAge-related macular degenerationCentral Angiographic Resource Facility (Belfast)Choroidal neo-vascularisationContrast sensitivityDesignated providerBinocular distance visual acuityEarly Treatment for Diabetic Retinopathy StudyFinal appraisal determinationGreatest lesion diameterGeneral practitionerLog minimum angle of resolutionLocal research ethics committeeLocal specialist commissioning groupMonocular distance visual acuityMulti-centre research ethics committeeNational Eye Institute Visual Functioning QuestionnaireNational Institute for Clinical ExcellenceNational Coordinating Centre for Health Technology AssessmentPrimary care trustPhotodynamic therapyQuality of lifeRoyal College of OphthalmologistsStandard deviationShort-Form 36 item questionnaireSub-Foveal RADiotheraphy StudySelf-reported visual function‘Treatment of Age-related macular degeneration by photodynamicTherapy’ study‘Visudyne In Photodynamic therapy’ study© Queen’s Printer and Controller of HMSO 2012. This work was produced by Reeves et al. under the terms of a commissioning contract issued by theSecretary of State for Health.
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DOI: 10.3310/hta16060Health Technol
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xExecutive summaryretreat on criter
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xiiExecutive summaryof data, with i
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2 Introductionon-going or new clini
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4 Introductionof VPDT in routine cl
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20 Key changes to the protocolThese
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22 Key changes to the protocolCentr
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24 Key changes to the protocolADVER
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26 Key changes to the protocolPlan
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28 Key changes to the protocolClass
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30 Key changes to the protocolFor i
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32 Key changes to the protocolIn ad
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34 Key changes to the protocolsites
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38 Results (1) - study cohortTABLE
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Page 60 and 61: 46 Results (2) - objectives A, B, C
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Page 80 and 81: 66 Discussion of resultsStrengths a
Page 82 and 83: 68 Discussion of resultsThe VPDT st
Page 84 and 85: 70 Discussion of resultsOur analyse
Page 86 and 87: 72 Discussion of resultsA further c
Page 88 and 89: 74 Discussion of resultsVPDT. It is
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Page 98 and 99: 84 References16. Stelmack J. Qualit
Page 100 and 101: 86 References49. Guymer RH, Chiu AW
Page 102 and 103: 88 References83. Margrain TH. Minim
Page 106 and 107: 92 Appendix 11. Overview of Manual
Page 108 and 109: 94 Appendix 1And, if also collectin
Page 110 and 111: 96 Appendix 1more patients in the v
Page 112 and 113: 98 Appendix 12.4 Limitations of the
Page 114 and 115: 100 Appendix 1Box 2 Key advantages
Page 116 and 117: 102 Appendix 14. Study population4.
Page 118 and 119: 104 Appendix 15. Recruitment to the
Page 120 and 121: 106 Appendix 16. Background data co
Page 122 and 123: 108 Appendix 1Table 1: Schedule of
Page 124 and 125: 110 Appendix 1The Verteporfin Photo
Page 126 and 127: 112 Appendix 1• Additional clinic
Page 128 and 129: 114 Appendix 18. Recording adverse
Page 130 and 131: 116 Appendix 1level of benefit from
Page 132 and 133: 118 Appendix 1• comparison of num
Page 134 and 135: 120 Appendix 110.6 Sub-group analys
Page 136 and 137: 122 Appendix 112. Data issues12.1 D
Page 138 and 139: 124 Appendix 113. Organisation13.1
Page 140 and 141: 126 Appendix 114. References[1] Ref
Page 142 and 143: 128 Appendix 1Barnes RM, Gee L, Tay
Page 144 and 145: 130 Appendix 1Appendix 1: Classifyi
Page 146 and 147: 132 Appendix 1Liverpool re-treatmen
Page 148 and 149: 134 Appendix 1Service StructurePlea
Page 150 and 151: 136 Appendix 1Has your photographer
Page 152 and 153: 138 Appendix 1There are many differ
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140 Appendix 1testing on vision tes
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142 Appendix 1something to do with
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144 Appendix 1College of Ophthalmol
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146 Appendix 1Appendix 5:Protocol f
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148 Appendix 16.2 Subjective Refrac
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150 Appendix 1• The patient shoul
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152 Appendix 1Appendix 6:Protocol f
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154 Appendix 18. It is customary to
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156 Appendix 1Early or Transit Phas
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158 Appendix 1
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160 Appendix 1---------------------
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162 Appendix 1---------------------
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164 Appendix 1---------------------
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166 Appendix 1Appendix 9:Site imple
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168 Appendix 1Option 2 - units inte
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170 Appendix 1Dos and Don’tsDosDo
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172 Appendix 1Resource use question
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174 Appendix 1Appendix 11: Recommen
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176 Appendix 1ADVERSE REACTION AND
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178 Appendix 1acute Trust; note tha
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180 Appendix 1Ophthalmologistrespon
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192 Appendix 3manufacturer’s pers
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FeedbackThe HTA programme and the a
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