Post Stroke Depression

The Lancet 2009: Cipriani et al.Background• Independently funded meta-analysis that compared theefficacy and patient acceptability of 12 antidepressants• 117 randomised clinical trials (25 928 participants) from1991 - 30 th Nov. 2007• Included 12 new-generation anti-depressants:bupropion, citalopram, duloxetine, escitalopram, fluoxetine,fluvoxamine, milnacipran, mirtazapine, paroxetine, reboxetine,sertraline and venlafaxine• Assessed the acute treatment phase (first 8 weeks oftreatment) in adults with unipolar major depressive disorderCipriani et al., Lancet 2009; 373: 746-58