Post Stroke Depression
Post Stroke Depression
Post Stroke Depression
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Traditional (anecdotal) Therapies•Stimulants used even before the development ofantidepressants•MAOIs were not favoured due to side-effects•TCA’s long history though side-effects were limiting•Amitryptylline, imipramine, desipramine, trimipramine, doxepin(maprotiline) etc. All TCA’s•Trazadone used for mixed anxiety –depressive states•Desipramine still popular due to Noradrenergic action andminimal anticholinergic side effects•Specific benefit for emotionalism (? Mode of action)•Recent increased concern about prolonged QTc
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