Sircol Publications - Tebu-Bio

2009 

Allograft Collagen 

Sircol Assay Citations in Scientific Literature 

Abreu,E.L., Palmer,M.P. and Murray,M.M. (2009) Storage conditions do not have detrimental effect on allograft 

collagen or scaffold performance. Cell and Tissue Banking, 10, 333-340. 

Murine Colon 

Alexandra,M., Arthur,W., Van,P. and Derek,M. (2009) Infection with Hymenolepis diminuta Is More Effective than Daily 

Corticosteroids in Blocking Chemically Induced Colitis in Mice. Journal of Biomedicine and Biotechnology, doi: 

10.1155/2010/384523. 

MC3T3-E1 Pre-Osteoblasts 

Alford,A.I., Terkhorn,S.P., Reddy,A.B. and Hankenson,K.D. (2009) Thrombospondin-2 regulates matrix mineralization in 

MC3T3-E1 pre-osteoblasts. Bone, doi: 10.1016/j.bone.2009.08.058. 

Fibroblast Cells 

Aramwit,P., Kanokpanont,S., De-Eknamkul,W., Kamei,K. and Srichana,T. (2009) The Effect of Sericin with Variable 

Amino-Acid Content from Different Silk Strains on the Production of Collagen and Nitric Oxide. Journal of 

Biomaterials Science, Polymer Edition, 20, 1295-1306. 

Fibroblast Populated Fibrin Gels 

Balestrini,J.L. and Billiar,K.L. (2009) Magnitude and Duration of Stretch Modulate Fibroblast Remodeling. Journal of 

Biomechanical Engineering, 131, 051005. 

Osteoblasts 

Ball,M.D., O’Connor,D. and Pandit,A. (2009) Use of tissue transglutaminase and fibronectin to influence osteoblast 

responses to tricalcium phosphate scaffolds. Journal of Materials Science: Materials in Medicine, 20, 113-122. 

Murine Lung Tissue 

Banerjee,E.R., Jiang,Y., Henderson,W.R., Latchman,Y. and Papayannopoulou,T. (2009) Absence of α4 but not ß2 

integrins restrains development of chronic allergic asthma using mouse genetic models. Experimental 

Hematology, 37, 715-727. 

Murine Renal Tissue and a Proximal Tubule Epithelial Cell Line (HK-2 Cells) 

Bani-Hani,A.H., Leslie,J.A., Asanuma,H., Dinarello,C.A., Campbell,M.T., Meldrum,D.R., Zhang,H., Hile,K. and 

Meldrum,K.K. (2009) IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition 

and renal fibrosis. Kidney International, 76, 500-511. 

Human Fibroblasts 

Bendersky,A., Markovits,N. and Bank,I. (2009) Vγ9+ γδT cells in systemic sclerosis patients are numerically and 

functionally preserved and induce fibroblast apoptosis. Immunobiology, doi: 10.1016/j.imbio.2009.05.012. 

Mesenchymal Stem Cells on Chitosan Scaffold 

Breyner, N.M., Hell, R.C.R., Carvalho, L.R.P., Machado, C.B., Peixoto Filho, I.N., Valério, P., Pereira, M.M. 

and Goes, A.M. (2009) Effect of a Three-Dimensional Chitosan Porous Scaffold on the Differentiation 

of Mesenchymal Stem Cells into Chondrocytes. Cells Tissues Organs, doi: 10.1159/000231472.

NIH 3T3 Fibroblasts 

Chen,M., Michaud,H. and Bhowmick,S. (2009) Controlled Vacuum Seeding as a Means of Generating Uniform Cellular 

Distribution in Electrospun Polycaprolactone (PCL) Scaffolds. Journal of Biomechanical Engineering, 131, 

074521. 


Choi,H., Kim,D., Kim,J.W., Ngadiran,S., Sarmidi,M.R. and Park,C.S. (2009) Labisia pumila extract protects skin cells 

from photoaging caused by UVB irradiation. Journal of Bioscience and Bioengineering, doi: 

10.1016/j.biosc.2009.08.478. 

Rat Dorsal Tissue 

Chung,P.S., Shin,J.I., Chang,S.Y. and Ahn,J.C. (2009) Histological Change and Collagen Formation on Laser Wounded 

Rat using 808 Diode Laser and CO2 Laser. Science for the Life of Issue 1, 15, 81-86. 


Couillin,I., Vasseur,V., Charron,S., Gasse,P., Tavernier,M., Guillet,J., Lagente,V., Fick,L., Jacobs,M. and Coelho,F.R. 

(2009) IL-1R1/MyD88 Signaling Is Critical for Elastase-Induced Lung Inflammation and Emphysema. The Journal 

of Immunology, 183, 8195. 

Human Mucosal Myofibroblasts 

Di Sabatino,A., Jackson,C.L., Pickard,K.M., Buckley,M., Rovedatti,L., Leakey,N.A.B., Picariello,L., Cazzola,P., 

Monteleone,G. and Tonelli,F. (2009) Transforming growth factor ß signalling and matrix metalloproteinases in 

the mucosa overlying Crohn's disease strictures. British Medical Journal, 58, 777-789. 


Du,G., Jin,L., Han,X., Song,Z., Zhang,H. and Liang,W. (2009) Naringenin: A Potential Immunomodulator for Inhibiting 

Lung Fibrosis and Metastasis. Cancer Research, 69, 3205. 

Porcine Bone Marrow-Derived Mesenchymal Cells (bMSCs) 

Elder,S.H., Cooley Jr,A.J., Borazjani,A., Sowell,B.L., To,H. and Tran,S.C. (2009) Production of Hyaline-like Cartilage by 

Bone Marrow Mesenchymal Stem Cells in a Self-Assembly Model. Tissue Engineering Part A, 15, 3025 – 3036. 


Failla,M., Genovese,T., Mazzon,E., Fruciano,M., Fagone,E., Gili,E., Barera,A., La Rosa,C., Conte,E. and Crimi,N. (2009) 

16, 16-Dimethyl Prostaglandin E2 Efficacy on Prevention and Protection from Bleomycin-Induced Lung Injury 

and Fibrosis. American Journal of Respiratory Cell and Molecular Biology, 41, 50 – 58. 

Skeletal Muscle Construct from C2C12 Myoblast Cell Line 

Fujita,H., Shimizu,K. and Nagamori,E. (2009) Novel method for fabrication of skeletal muscle construct from the C2C12 

myoblast cell line using serum-free medium AIM-V. Biotechnology and Bioengineering, 103, 1034-1041. 


Fukumoto,J., Harada,C., Kawaguchi,T., Suetugu,S., Maeyama,T., Inoshima,I., Hamada,N., Kuwano,K. and Nakanishi,Y. 

(2009) Amphiregulin attenuates bleomycin-induced pneumopathy in mice. American Journal of Physiology- 

Lung Cellular and Molecular Physiology, doi: 10.1152/ajplung.90576.2008. 


Gill,S.E., Huizar,I., Bench,E.M., Sussman,S.W., Wang,Y., Khokha,R. and Parks,W.C. (2010) Tissue Inhibitor of 

Metalloproteinases 3 Regulates Resolution of Inflammation following Acute Lung Injury. American Journal of 

Pathology, 176, 64-73.


Glass,W.G., Argentieri,R.L., Bracht,M., Farrell,F.X., Das,A.M., Del Vecchio,A.M., Hogaboam,C.M. and Murray,L.A. 

(2009) Generation of bleomycin-induced lung fibrosis is independent of IL-16. Cytokine, 46, 17–23. 

Atherosclerotic Carotid Plaques 

Gonçalves,I., Stollenwerk,M.M., Lindholm,M.W., Dias,N., Pedro,L.M., Fernandes,J.F., Moses,J., Fredrikson,G.N., 

Nilsson,J. and Ares,M.P.S. (2009) Activator protein-1 in carotid plaques is related to cerebrovascular symptoms 

and cholesteryl ester content. Cardiovascular Pathology, doi: 10.1016/j.carpath.2009.09.003. 

Human Bone Marrow Stromal Cells 

Green,D.W., Bolland,B.J.R.F., Kanczler,J.M., Lanham,S.A., Walsh,D., Mann,S. and Oreffo,R.O.C. (2009) Augmentation 

of skeletal tissue formation in impaction bone grafting using vaterite microsphere biocomposites. Biomaterials, 

30, 1918-1927. 

Murine Colon Tissue 

Guan,Q., Ma,Y., Hillman,C.L., Ma,A., Zhou,G., Qing,G. and Peng,Z. (2009) Development of recombinant vaccines 

against IL-12/IL-23 p40 and in vivo evaluation of their effects in the downregulation of intestinal inflammation 

in murine colitis. Vaccine, 27, 7096 – 7104. 

Articular Cartilages from Human Knee Joint 

Han,D.W., Bae,J.Y. and Hyon,S.H. (2009) Biochemical and Histological Evaluations of Articular Cartilages Preserved in 

Cold Storage Solution Containing Green Tea Catechin, EGCG. Tissue Engineering and Regenerative Medicine, 6, 

380-387. 

Murine Asthma Model 

Hansen,G. (2009) Different role of CD30 in the development of acute and chronic airway inflammation in a murine 

asthma model. Eur.J.Immunol, 39, 1736-1742. 

Bladder Smooth Muscle Cells 

Heise,R.L., Ivanova,J., Parekh,A. and Sacks,M.S. (2009) Generating Elastin-Rich Small Intestinal Submucosa-Based 

Smooth Muscle Constructs Utilizing Exogenous Growth Factors and Cyclic Mechanical Stimulation. Tissue 

Engineering Part A, 15, 3951-3960. 

Rat Renal Tissue 

He,L., Qi,Y., Rong,X., Jiang,J., Yang,Q., Yamahara,J., Murray,M. and Li,Y. (2009) The Ayurvedic medicine Salacia 

oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evidence-based 

Complementary and Alternative Medicine, doi: 10.1093/ecam/nep095. 

Murine Lung Mesenchymal Cells and Myofibroblasts 

Hecker,L., Vittal,R., Jones,T., Jagirdar,R., Luckhardt,T.R., Horowitz,J.C., Pennathur,S., Martinez,F.J. and 

Thannickal,V.J. (2009) NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung 

injury. Nature Medicine, 15, 1077-1081. 

Human Skin Fibroblasts 

Hemmatazad,H., Rodrigues,H.M., Maurer,B., Brentano,F., Pileckyte,M., Distler,J.H.W., Gay,R.E., Michel,B.A., Gay,S. 

and Huber,L.C. (2009) Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic 

sclerosis. Arthritis & Rheumatism, 60, 1519-1529.

Rabbit Subcutaneous Implant Model 

Henry,J.A., Burugapalli,K., Neuenschwander,P. and Pandit,A. (2009) Structural variants of biodegradable 

polyesterurethane in vivo evoke a cellular and angiogenic response that is dictated by architecture. Acta 

Biomaterialia, 5, 29-42. 

Rat Cardiac Fibroblasts 

Hermida,N., Lopez,B., Gonzalez,A., Dotor,J., Lasarte,J.J., Sarobe,P., Borras-Cuesta,F. and Diez,J. (2009) A synthetic 

peptide from transforming growth factor-β 1 type III receptor prevents myocardial fibrosis in spontaneously 

hypertensive rats. Cardiovascular Research, 81, 601. 

Murine Embryonic Fibroblasts and Primary Hepatocytes 

Hosui,A., Kimura,A., Yamaji,D., Zhu,B., Na,R. and Hennighausen,L. (2009) Loss of STAT5 causes liver fibrosis and 

cancer development through increased TGF-ß and STAT3 activation. Journal of Experimental Medicine, 

doi:10.1084/jem.20080003. 

Human Osteoarthritis Cartilage explants and a Rabbit Model of Osteoarthritis 

Huh,J.E., Baek,Y.H., Ryu,S.R., Lee,J.D., Choi,D.Y. and Park,D.S. (2009) Efficacy and mechanism of action of KHBJ-9B, 

a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit model 

of collagenase-induced osteoarthritis. International Immunopharmacology, 9, 230-240. 

Mouse Osteoclasts 

Idris,A.I., Greig,I.R., Bassonga-Landao,E., Ralston,S.H. and van't Hof,R.J. (2009) Identification of Novel Biphenyl 

Carboxylic Acid Derivatives as Novel Antiresorptive Agents that Do Not Impair Parathyroid Hormone-Induced 

Bone Formation. Endocrinology, 150, 5-13. 

Human Term Fetal Membranes 

Jabareen,M., Mallik,A.S., Bilic,G., Zisch,A.H. and Mazza,E. (2009) Relation between mechanical properties and 

microstructure of human fetal membranes: An attempt towards a quantitative analysis. European Journal of 

Obstetrics and Gynecology, 144, 134-141. 


Kakizaki,T., Kohno,M., Watanabe,M., Tajima,A., Izumi,Y., Miyasho,T., Tasaka,S., Fukunaga,K., Maruyama,I. and 

Ishizaka,A. (2009) Exacerbation of Bleomycin-Induced Injury and Fibrosis by Pneumonectomy in the Residual 

Lung of Mice. Journal of Surgical Research, 154, 336-344. 


Kanda,A., Driss,V., Hornez,N., Abdallah,M., Roumier,T., Abboud,G., Legrand,F., Staumont-Sallé�D., Quéant,S. and 

Bertout,J. (2009) Eosinophil-derived IFN- induces airway hyperresponsiveness and lung inflammation in the 

absence of lymphocytes. The Journal of Allergy and Clinical Immunology, 124, 573-582. 

Rat Renal Tissue and Cultured Mesangial Cells 

Kang,Y.S., Ko,G.J., Lee,M.H., Song,H.K., Han,S.Y., Han,K.H., Kim,H.K., Han,J.Y. and Cha,D.R. (2009) Effect of 

eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats. 

Nephrology Dialysis Transplantation, 24, 73-84. 

Murine Skin Tissue 

Kanno,Y., Kawashita,E., Minamida,M., Kaneiwa,A., Okada,K., Ueshima,S., Matsuo,O. and Matsuno,H. (2009) α2- 

Antiplasmin Is Associated with the Progression of Fibrosis. American Journal of Pathology, doi: 

10.2353/ajpath.2010.090150.

Human Dermal Fibroblasts 

Kim,H.J., Song,S.B., Lee,J.Y., Cho,B.K., Cho,D.H. and Park,H.J. (2009) Interleukin-18 Downregulates Collagen 

Production in Human Dermal Fibroblasts via ERK pathway. The Journal of Immunology, 182, 98-14. 

Rat Ear Fibroblast Cells 

Kim, J.-H. and Choi, J.-Y. (2009) Study on thermosensitivity of chitosan scaffold and on its effects on fibroblast 

proliferation in cell therapy for soft tissue augmentation. J. Kor. Oral Maxillofac. Surg., 35, 146-152. 

Rat Common Bile Duct Fibroblasts 

Kim,T.H., Moon,J.H., Savard,C.E., Kuver,R. and Lee,S.P. (2009) Effects of lipopolysaccharide on platelet-derived 

growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes. 

Journal of Gastroenterology and Hepatology, 24, 1218-1225. 

Osteoblastic MC3T3-E1 Cells 

Kim,Y.H. and Choi,E.M. (2009) Stimulation of osteoblastic differentiation and inhibition of interleukin-6 and nitric 

oxide in MC3T3-E1 cells by pomegranate ethanol extract. Phytotherapy Research, 23, 737-739. 

Immobilised Matrix Vesicle Model 

Kinugawa,M., Fukuzawa,S. and Tachibana,K. (2009) Skeletal protein protection: the mode of action of an antiosteoporotic 

marine alkaloid, norzoanthamine. Journal of Bone and Mineral Metabolism, 27, 303-314. 

Mouse and Human Lung Fibroblasts 

Königshoff,M., Kramer,M., Balsara,N., Wilhelm,J., Amarie,O.V., Jahn,A., Rose,F., Fink,L., Seeger,W. and Schaefer,L. 

(2009) WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans 

with idiopathic pulmonary fibrosis. The Journal of Clinical Investigation, 119, 772-787. 

Murine Bone Marrow Mesenchymal Stem Cells 

Kumamoto,M., Nishiwaki,T., Matsuo,N., Kimura,H. and Matsushima,K. (2009) Minimally-cultured Bone Marrow 

mesenchymal stem cells ameliorate fibrotic lung injury. European Respiratory Journal, doi:10.1183/ 

09031936-00128508. 

Mouse Breast Cell Line 

Lee,C.G., Hartl,D., Lee,G.R., Koller,B., Matsuura,H., Da Silva,C.A., Sohn,M.H., Cohn,L., Homer,R.J. and Kozhich,A.A. 

(2009) Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue 

responses and apoptosis. Journal of Experimental Medicine, 206, 1149-1166. 

Chondrocytes 

Lee,N.K., Oh,H.J., Hong,C.M., Suh,H. and Hong,S.H. (2009) Comparison of the synthetic biodegradable polymers, 

polylactide (PLA), and polylactic-co-glycolic acid (PLGA) as scaffolds for artificial cartilage. Biotechnology and 

Bioprocess Engineering, 14, 180-186. 


Lee,J., Reddy,R., Barsky,L., Scholes,J., Chen,H., Shi,W. and Driscoll,B. (2009) Lung alveolar integrity is compromised 

by telomere shortening in telomerase-null mice. American Journal of Physiology- Lung Cellular and Molecular 

Physiology, 296, L57. 


Lefler,A. and Ghanem,A. (2009) Development of bFGF-Chitosan Matrices and Their Interactions with Human Dermal 

Fibroblast Cells. Journal of Biomaterials Science, Polymer Edition, 20, 1335-1351.

Connective Tissue and Fibroblasts 

Lin,Y.K. and Kuan,C.Y. (2009) Development of 4-hydroxyproline analysis kit and its application to collagen 

quantification. Food Chemistry, doi: 10.1016/j.foodchem.2009.08.009. 

Rat Hepatic Stellate Cells 

Lin,Y.L., Lin,C.Y., Chi,C.W. and Huang,Y.T. (2009) Study on antifibrotic effects of curcumin in rat hepatic stellate 

cells. Phytotherapy Research, 23, 927-932. 

Rat Hepatic Stellate Cell Line (HSC-T6) 

Lin,Y.L., Wu,C.F. and Huang,Y.T. (2009) Effects of rhubarb on migration of rat hepatic stellate cells. Journal of 

Gastroenterology and Hepatology, 24, 453-461. 

Human Myocardium 

Lopez,B., Querejeta,R., Gonzalez,A., Beaumont,J., Larman,M. and Diez,J. (2009) Impact of Treatment on Myocardial 

Lysyl Oxidase Expression and Collagen Cross-Linking in Patients With Heart Failure. Hypertension, 53, 236-242. 

Osteoblastic Cell Cultures 

Lozano,D., Manzano,M., Doadrio,J.C., Salinas,A.J., Vallet-Regí�M., Gómez-Barrena,E. and Esbrit,P. (2009) Osteostatinloaded 

bioceramics stimulate osteoblastic growth and differentiation. Acta Biomaterialia, doi: 

10.1016/j.actbio.2009.08.033. 

Bone Marrow Cultures and Osteoblastic MC3T3-E1 Cells 

Lozano,D., de Castro,L.F., Dapía,S., Andrade-Zapata,I., Manzarbeitia,F., Ayvarez-Arroyo,M., Gómez-Barrena,E. and 

Esbrit,P. (2009) Role of Parathyroid Hormone-Related Protein in the Decreased Osteoblast Function in 

Diabetes-Related Osteopenia. Endocrinology, 150, 2027-2035. 


Manicone,A.M., Huizar,I. and McGuire,J.K. (2009) Matrilysin (Matrix Metalloproteinase-7) Regulates Anti-Inflammatory 

and Antifibrotic Pulmonary Dendritic Cells That Express CD103 αE ß7-Integrin). American Journal of Pathology, 

175, 2319 – 2331. 


Markart,P., Luboeinski,T., Korfei,M., Schmidt,R., Wygrecka,M., Mahavadi,P., Mayer,K., Wilhelm,J., Seeger,W. and 

Guenther,A. (2009) Alveolar Oxidative Stress is Associated with Elevated Levels of Nonenzymatic Low- 

Molecular-Weight Antioxidants in Patients with Different Forms of Chronic Fibrosing Interstitial Lung Diseases. 

Antioxidants & Redox Signaling, 11, 227-240. 

Human Fibrocytes 

Mehrad,B., Burdick,M.D. and Strieter,R.M. (2009) Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary 

fibrosis. International Journal of Biochemistry and Cell Biology, 41, 1708-1718. 

Human Retinal Pigment (ARPE-19) Cell Line 

Morales,S.A., Mareninov,S., Wadehra,M., Zhang,L., Goodglick,L., Braun,J. and Gordon,L.K. (2009) FAK Activation and 

the Role of Epithelial Membrane Protein 2 (EMP2) in Collagen Gel Contraction. Investigative Ophthalmology & 

Visual Science, 50, 462-469.

EpiDerm FT Engineered Skin, Murine Epidermal Cells (JB6 P+) and Immune-Competent Hairless SKH-1 Mice 

Murray,A.R., Kisin,E., Leonard,S.S., Young,S.H., Kommineni,C., Kagan,V.E., Castranova,V. and Shvedova,A.A. (2009) 

Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes. Toxicology, 

257, 161-171. 

Murine Peritoneal Fibroblasts 

Nakav,S., Kachko,L., Vorobiov,M., Rogachev,B., Chaimovitz,C., Zlotnik,M. and Douvdevani,A. (2009) Blocking 

adenosine A2A receptor reduces peritoneal fibrosis in two independent experimental models. Nephrology 

Dialysis Transplantation, doi:10.1093/ndt/gfp041. 

Bovine Chondrocytes Seeded in Non-Adherent Agarose Molds 

Natoli,R.M., Revell,C.M. and Athanasiou,K.A. (2009) Chondroitinase ABC Treatment Results in Increased Tensile 

Properties of Self-Assembled Tissue Engineered Articular Cartilage. Tissue Engineering.Part A, 15, 3119 – 3128. 


Nicola,T., Hagood,J.S., James,M.L., MacEwen,M.W., Williams,T.A., Hewitt,M.M., Schwiebert,L., Bulger,A., Oparil,S. 

and Chen,Y.F. (2009) Loss of Thy-1 inhibits alveolar development in the newborn mouse lung. American 

Journal of Physiology- Lung Cellular and Molecular Physiology, 296, L738-L750. 


Niese,K.A., Collier,A.R., Hajek,A.R., Cederbaum,S.D., O'Brien,W.E., Wills-Karp,M., Rothenberg,M.E. and 

Zimmermann,N. (2009) Bone marrow cell derived arginase I is the major source of allergen-induced lung 

arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in 

mice. BMC Immunology, 10, 33. 

Murine Lung Fibroblasts 

Oga,T., Matsuoka,T., Yao,C., Nonomura,K., Kitaoka,S., Sakata,D., Kita,Y., Tanizawa,K., Taguchi,Y. and Chin,K. (2009) 

Prostaglandin F2 αreceptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of 

transforming growth factor-ß. Nature medicine, 15, 1426-1430. 

Human Lung Fibroblasts 

Okada,M., Suzuki,K., Matsumoto,M., Takada,K., Nakanishi,T., Horikoshi,H., Higuchi,T., Hosono,Y., Nakayama,M. and 

Ohsuzu,F. (2009) Effects of angiotensin on the expression of fibrosis-associated cytokines, growth factors, and 

matrix proteins in human lung fibroblasts. Journal of Clinical Pharmacy & Therapeutics, 34, 289-299. 

Rat Calvariae Osteoblasts 

Orriss,I.R., Key,M.L., Colston,K.W. and Arnett,T.R. (2009) Inhibition of osteoblast function in vitro by 

aminobisphosphonates. Journal of Cellular Biochemistry, 106, 109-118. 

Swiss Mouse Intraplantar Region 

Pareja-Santos,A., Saraiva,T.C., Costa,E.P., Santos,M.F., Zorn,T.T., Souza,V.M.O., Lopes-Ferreira,M. and Lima,C. (2009) 

Delayed local inflammatory response induced by Thalassophryne nattereri venom is related to extracellular 

matrix degradation. International Journal of Experimental Pathology, 90, 34-43. 


Park,H.J., Cho,D.H., Kim,H.J., Lee,J.Y., Cho,B.K., Bang,S.I., Song,S.Y., Yamasaki,K., Di Nardo,A. and Gallo,R.L. (2009) 

Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37. The Journal 

of investigative dermatology, 129, 843-850.

Rat Respiratory Tract 

Pauluhn,J. (2009) Subchronic 13-week Inhalation Exposure of Rats to Multiwalled Carbon Nanotubes: Toxic Effects are 

determined by Density of Agglomerate Structures, not fibrillar Structures. Toxicological Sciences, doi: 

10.1093/toxsci/kfp247. 

Tissue Engineered Valve Constructs Seeded With Mesenchymal Stem Cells 

Ramaswamy,S., Gottlieb,D., Engelmayr,G.C., Aikawa,E., Schmidt,D.E., Gaitan-Leon,D.M., Sales,V.L., Mayer,J.E. and 

Sacks,M.S. (2010) The role of organ level conditioning on the promotion of engineered heart valve tissue 

development in-vitro using mesenchymal stem cells. Biomaterials, 31, 1114-1125. 


Ryman-Rasmussen,J.P., Tewksbury,E.W., Moss,O.R., Cesta,M.F., Wong,B.A. and Bonner,J.C. (2009) Inhaled multiwalled 

carbon nanotubes potentiate airway fibrosis in murine allergic asthma. American Journal of Respiratory Cell 

and Molecular Biology, 40, 349-358. 

Dermal Fibroblasts 

Saesoo,S., Sramala,I., Soottitantawat,A., Charinpanitkul,T. and Ruktanonchai,U.R. (2009) Enhanced stability and in 

vitro bioactivity of surfactant-loaded liposomes containing Asiatic Pennywort extract. Journal of 

Microencapsulation, doi: 10.3109/02652040903447686. 

Ovine Peripheral Blood Endothelial Progenitor Cells 

Sales,V.L., Mettler,B.A., Engelmayr Jr,G.C., Aikawa,E., Bischoff,J., Martin,D.P., Exarhopoulos,A., Moses,M.A., 

Schoen,F.J. and Sacks,M.S. (2009) Endothelial Progenitor Cells as a Sole Source for Ex Vivo Seeding of Tissue- 

Engineered Heart Valves. Tissue Engineering Part A, doi: 10.1089/ten.tea.2009.0424. 

Human Heart Valves 

Schenke-Layland,K., Stock,U.A., Nsair,A., Xie,J., Angelis,E., Fonseca,C.G., Larbig,R., Mahajan,A., Shivkumar,K., 

Fishbein,M.C. and MacLellan, W.R. (2009) Cardiomyopathy is associated with structural remodelling of heart 

valve extracellular matrix. European Heart Journal, 30, 2254-2265. 

Human Foreskin Fibroblasts 

Schenke-Layland,K., Rofail,F., Heydarkhan,S., Gluck,J.M., Ingle,N.P., Angelis,E., Choi,C.H., MacLellan,W.R., 

Beygui,R.E. and Shemin,R.J. (2009) The use of three-dimensional nanostructures to instruct cells to produce 

extracellular matrix for regenerative medicine strategies. Biomaterials, 30, 4665-4675. 

Mesenchymal Stem Cells 

Schnabel,L.V., Lynch,M.E., van der Meulen,M.C.H., Yeager,A.E., Kornatowski,M.A. and Nixon,A.J. (2009) Mesenchymal 

stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects 

of healing in equine flexor digitorum superficialis tendons. Journal of Orthopaedic Research, 27, 1392-1398. 

Murine Airways 

Schneider,D.J., Lindsay,J.C., Zhou,Y., Molina,J.G. and Blackburn,M.R. (2009) Adenosine and osteopontin contribute to 

the development of chronic obstructive pulmonary disease. The FASEB Journal, doi: 10.1096/fj.09-140772. 

Anterior Cruciatge Ligament Cell and T-Lymophocytes on Composite Silk Scaffolds 

Seo,Y.K., Yoon,H.H., Song,K.Y., Kwon,S.Y., Lee,H.S., Park,Y.S. and Park,J.K. (2009) Increase in cell migration and 

angiogenesis in a composite silk scaffold for tissue-engineered ligaments. Journal of Orthopaedic Research, 

27, 495-503.

Murine Skin and Lung Tissue 

Servettaz,A., Goulvestre,C., Kavian,N., Nicco,C., Guilpain,P., Chereau,C., Vuiblet,V., Guillevin,L., Mouthon,L. and 

Weill,B. (2009) Selective Oxidation of DNA Topoisomerase 1 Induces Systemic Sclerosis in the Mouse. The 

Journal of Immunology, 182, 5855-5864. 

Murine Conjunctival Tissue 

Shii,D., Nakagawa,S., Shinomiya,K., Yoshimi,M., Katsuta,O., Oda,T. and Nakamura,M. (2009) Cyclosporin A Eye Drops 

Inhibit Fibrosis and Inflammatory Cell Infiltration in Murine Type I Allergic Conjunctivitis without Affecting the 

Early-Phase Reaction. Current Eye Research, 34, 426-437. 

Smooth Muscle Cells 

Shin,J.W., Lee,Y.J., Heo,S.J., Park,S.A., Kim,S.H., Kim,Y.J., Kim,D.H. and Shin,J.W. (2009) Manufacturing of Multi- 

Layered Nanofibrous Structures Composed of Polyurethane and Poly (ethylene oxide) as Potential Blood Vessel 

Scaffolds. Journal of Biomaterials Science, Polymer Edition, 20, 5, 757-771. 

Rat Myogenic Cells from Large Thigh Muscle 

Stern,M.M., Myers,R.L., Hammam,N., Stern,K.A., Eberli,D., Kritchevsky,S.B., Soker,S. and Van Dyke,M. (2009) The 

influence of extracellular matrix derived from skeletal muscle tissue on the proliferation and differentiation of 

myogenic progenitor cells ex vivo. Biomaterials, 30, 2393-2399. 

Mesenchymal Progenitor Cells (Fibrocytes) 

Strieter,R.M., Keeley,E.C., Hughes,M.A., Burdick,M.D. and Mehrad,B. (2009) The role of circulating mesenchymal 

progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis. Journal of leukocyte biology, 86, 1111- 

1118. 

Mouse Osteoblastic Cell Line (MC3T3-E1) 

Suh,K.S., Choi,E.M., Kwon,M., Chon,S., Oh,S., Woo,J.T., Kim,S.W., Kim,J.W. and Kim,Y.S. (2009) Kaempferol 

Attenuates 2-Deoxy-D-ribose-Induced Oxidative Cell Damage in MC3T3-E1 Osteoblastic Cells. Biological & 

Pharmaceutical Bulletin, 32, 746-749. 

Rat Pancreatic Tissue 

Suzuki,N., Masamune,A., Kikuta,K., Watanabe,T., Satoh,K. and Shimosegawa,T. (2009) Ellagic Acid Inhibits Pancreatic 

Fibrosis in Male Wistar Bonn/Kobori Rats. Digestive Diseases and Sciences, 54, 802-810. 

Murine Patellar Tendons 

Szczodry,M., Zhang,J., Lim,C., Davitt,H.L., Yeager,T., Fu,F.H. and Wang,J.H.C. (2009) Treadmill running exercise 

results in the presence of numerous myofibroblasts in mouse patellar tendons. Journal of Orthopaedic 

Research, 27, 1373-1378. 

Human Embryonic Stem Cells (hESCs) 

Toh,W.S., Guo,X-M., Choo,A.B., Lu,K., Lee,E.H. and Cao,T. (2009) Differentiation and Enrichment of Expandable 

Chondrogenic Cells from Human Embryonic Stem Cells in Vitro. Journal of Cellular and Molecular Medicine, 

doi:10.1111/j.1582-4934.2009.00762.x. 

Murine Hepatic Tissue 

Tong,Z.Y., Chen,R., Alt,D.S., Kemper,S., Perbal,B. and Brigstock,D.R. (2009) Susceptibility to liver fibrosis in mice 

expressing a connective tissue growth factor transgene in hepatocytes. Hepatology, 50, 939-947.

Rat Liver Tissue 

Tsai,P.C., Fu,T.W., Chen,Y.M.A., Ko,T.L., Chen,T.H., Shih,Y.H., Hung,S.C. and Fu,Y.S. (2009) The therapeutic 

potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis. 

Liver Transplantation, 15, 484-495. 

Rat Glomeruli and Cultured Mesangial Cells 

Urushihara,M., Takamatsu,M., Shimizu,M., Kondo,S., Kinoshita,Y., Suga,K., Kitamura,A., Matsuura,S., Yoshizumi,M. 

and Tamaki,T. (2009) ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat 

progressive glomerulonephritis. American Journal of Physiology- Renal Physiology, doi: 

10.1152/ajprenal.00124.2009. 

Primary Human Cardiac Fibroblasts 

Venkatachalam,K., Venkatesan,B., Valente,A.J., Melby,P.C., Nandish,S., Reusch,J.E.B., Clark,R.A. and 

Chandrasekar,B. (2009) Wisp1, a pro-mitogenic, pro-survival factor, mediates TNF-alpha stimulated cardiac 

fibroblast proliferation, but inhibits TNF-alpha-induced cardiomyocyte death. Journal of Biological Chemistry, 

284, 14414-14427. 

Murine Diaphragm 

Vetrone,S.A., Montecino-Rodriguez,E., Kudryashova,E., Kramerova,I., Hoffman,E.P., Liu,S.D., Miceli,M.C. and 

Spencer,M.J. (2009) Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell 

subsets and intramuscular TGF-ß. The Journal of Clinical Investigation, 119, 1583-1594. 

Human Palmar Fascia Cells 

Vi,L., Njarlangattil,A., Wu,Y., Gan,B.S. and O'Gorman,D.B. (2009) Type-1 collagen differentially alters beta-catenin 

accumulation in primary Dupuytren's Disease cord and adjacent palmar fascia cells. BMC Musculoskeletal 

Disorders, 10, 72. 

Human Palmar Fascia Cells 

Vi,L., Feng,L., Zhu,R.D., Wu,Y., Satish,L., Gan,B.S. and O'Gorman,D.B. (2009) Periostin differentially induces 

proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells. 

Experimental Cell Research, 315, 3574 – 3586. 

Human Smooth Muscle Cells 

Wang,C., Cen,L., Yin,S., Liu,Q., Liu,W., Cao,Y. and Cui,L. (2010) A small diameter elastic blood vessel wall prepared 

under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adiposederived 

stem cells. Biomaterials, 31, 621-630. 

Murine Colonic Fibroblast Cells 

Wang,H., Zhang,R., Wen,S., McCafferty,D.M., Beck,P.L. and MacNaughton,W.K. (2009) Nitric oxide increases Wntinduced 

secreted protein-1 (WISP-1/CCN4) expression and function in colitis. Journal of Molecular Medicine, 

87, 435-445. 

Murine Calf Muscle 

Watanuki,M., Kishimoto,K.N., Kotajima,S., Iwabuchi,S. and Kokubun,S. (2009) Effect of low-intensity pulsed ultrasound 

on scaffold-free ectopic bone formation in skeletal muscle. Upsala Journal of Medical Sciences, 114, 242-248. 

Rat Stellate Liver Cell Line (HSC-T6) 

Weng,T.C., Shen,C.C., Chiu,Y.T., Lin,Y.L., Kuo,C.D. and Huang,Y.T. (2009) Inhibitory effects of armepavine against 

hepatic fibrosis in rats. Journal of Biomedical Science, 16, 78.


Wigenstam,E., Rocksén,D., Ekstrand-Hammarström,B. and Bucht,A. (2009) Treatment with dexamethasone or 

liposome-encapsuled vitamin E provides beneficial effects after chemical-induced lung injury. Inhalation 

Toxicology, 11, 958-964. 

Murine Skin and Lung Tissue 

Wu,M., Melichian,D.S., de la Garza,M., Gruner,K., Bhattacharyya,S., Barr,L., Nair,A., Shahrara,S., Sporn,P.H.S. and 

Mustoe,T.A. (2009) Essential Roles for Early Growth Response Transcription Factor Egr-1 in Tissue Fibrosis and 

Wound Healing. American Journal of Pathology, 175, 1041. 

Murine Model of Scleroderma 

Wu,M., Melichian,D.S., Chang,E., Warner-Blankenship,M., Ghosh,A.K. and Varga,J. (2009) Rosiglitazone Abrogates 

Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated 

Receptor-γ. American Journal of Pathology, 174, 519. 

Rat Liver Tissue 

Yasoshima,M., Sato,Y., Furubo,S., Kizawa,K., Sanzen,T., Ozaki,S., Harada,K. and Nakanuma,Y. (2009) Matrix proteins 

of basement membrane of intrahepatic bile ducts are degraded in congenital hepatic fibrosis and Caroli's 

disease No conflicts of interest were declared. The Journal of Pathology, 217, 442-451. 

Porcine Hind Leg Tibial Osteochondral Explants 

Yeow,C.H., Lau,S.T., Lee,P.V.S. and Goh,J.C.H. (2009) Damage and degenerative changes in menisci-covered and 

exposed tibial osteochondral regions after simulated landing impact compression-a porcine study. Journal of 

Orthopaedic Research, 27, 1100-1108. 

Equine Tendon Tissue 

Young,N.J., Becker,D.L., Fleck,R.A., Goodship,A.E. and Patterson-Kane,J.C. (2009) Maturational alterations in gap 

junction expression and associated collagen synthesis in response to tendon function. Matrix Biology, 28, 311- 

323. 

Mouse Embryonic Fibroblast Cell Line (NIH 3T3) 

Zhang,W., Rong,J., Wang,Q. and He,X. (2009) The encapsulation and intracellular delivery of trehalose using a 

thermally responsive nanocapsule. Nanotechnology, 20, 275101. 

Mouse Model of Atopic Dermatitis 

Zheng,T., Oh,M., Oh,S., Wu,F., Myers,A. and Zhu,Z. (2009) IL-13 Regulation of Skin Remodeling in a Mouse Model of 

Atopic Dermatitis. The Journal of Allergy and Clinical Immunology, 123, 35. 


Zhou,Y., Mohsenin,A., Morschl,E., Young,H.W.J., Molina,J.G., Ma,W., Sun,C.X., Martinez-Valdez,H. and Blackburn,M.R. 

(2009) Enhanced Airway Inflammation and Remodeling in Adenosine Deaminase-Deficient Mice Lacking the A2B 

Adenosine Receptor. The Journal of Immunology, 182, 8037-8046. 

2008 

Mouse Model of Dermal Fibrosis 

Akhmetshina,A., Dees,C., Pileckyte,M., Maurer,B., Axmann,R., Jungel,A., Zwerina,J., Gay,S., Schett,G. and Distler,O. 

(2008) Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of 

dermal fibrosis. The FASEB Journal, 22, 2214-2222.

Scleroderma Fibroblasts 

Akhmetshina,A., Dees,C., Pileckyte,M., Szucs,G., Spriewald,B.M., Zwerina,J., Distler,O., Schett,G. and Distler,J.H. 

(2008) Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular 

matrix in scleroderma fibroblasts. Arthritis Rheum, 58, 2553-2564. 

Rabbit Bone Marrow Cells Seeded on Porcine Small Intestine Submucosa 

Almarza,A.J., Yang,G., Woo,S.L.Y., Nguyen,T. and Abramowitch,S.D. (2008) Positive Changes in Bone Marrow-Derived 

Cells in Response to Culture on an Aligned Bioscaffold. Tissue Engineering, 14, 1489-1495. 


Antao-Menezes,A., Turpin,E.A., Bost,P.C., Ryman-Rasmussen,J.P. and Bonner,J.C. (2008) STAT-1 Signaling in Human 

Lung Fibroblasts Is Induced by Vanadium Pentoxide through an IFN-beta Autocrine Loop. The Journal of 

Immunology, 180, 4200-4207. 

Cultured Human Intrahepatic (Myo) Fibroblasts (hIHFs) 

Aoudjehane,L., Pissaia,A., Scatton,O., Podevin,P., Massault,P.P., Chouzenoux,S., Soubrane,O., Calmus,Y. and Conti,F. 

(2008) Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts 

via the STAT-6 pathway. Laboratory Investigation, 88, 973-985. 


Bhogal, R.K. and Bona, C.A. (2008) Regulatory Effect of Extracellular Signal- Regulated Kinases (ERK) on Type I 

Collagen Synthesis in Human Dermal Fibroblasts Stimulated by IL-4 and IL-13. International Reviews of 

Immunology, 27, 472 – 496. 

Porcine Valvular Interstitial Cells from Various Regions of the Mitral Valve 

Blevins,T.L., Peterson,S.B., Lee,E.L., Bailey,A.M., Frederick,J.D., Huynh,T.N., Gupta,V. and Grande-Allen,K. (2008) 

Mitral Valvular Interstitial Cells Demonstrate Regional, Adhesional, and Synthetic Heterogeneity. Cells Tissues 

Organs, 187, 113-122. 

Human Lung Fibroblasts and Mouse Bleomycin Induced Lung Fibrosis 

Borie,R., Fabre,A., Prost,F., Marchal-Somme,J., Lebtahi,R., Marchand-Adam,S., Aubier,M., Soler,P. and Crestani,B. 

(2008) Activation of somatostatin receptors attenuates pulmonary fibrosis. Thorax, 63, 251-258. 

An Alloxan Rabbit Ear Ulcer Model 

Breen,A.M., Dockery,P., O'Brien,T. and Pandit,A.S. (2008) The use of therapeutic gene eNOS delivered via a fibrin 

scaffold enhances wound healing in a compromised wound model. Biomaterials, 29, 3143-3151. 

Polycarbonate Track-Etched Membranes 

Bueno,E.M. and Ruberti,J.W. (2008) Optimizing collagen transport through track-etched nanopores. Journal of 

Membrane Science, 321, 250-263. 


Caraci,F., Gili,E., Calafiore,M., Failla,M., La Rosa,C., Crimi,N., Sortino,M.A., Nicoletti,F., Copani,A. and Vancheri,C. 

(2008) TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of human lung 

fibroblasts into myofibroblasts. Pharmacological Research, 57, 274-282. 

Fetal Rat Lung Tissue 

Chen,C.M., Chou,H.C., Wang,L.F. and Lang,Y.D. (2008) Experimental Oligohydramnios Decreases Collagen in 

Hypoplastic Fetal Rat Lungs. Experimental Biology and Medicine, 233, 1334-1340.

Rabbit Digitorum Extensor Tendon 

Chen,C.H., Liu,H.W., Tsai,C.L., Yu,C.M. and Lin,I. (2008) Photoencapsulation of Bone Morphogenetic Protein-2 and 

Periosteal Progenitor Cells Improve Tendon Graft Healing in a Bone Tunnel. The American Journal of Sports 

Medicine, 36, 461-473. 

Murine Osteoblastic MC3T3-E1 Cells 

Choi,E.M. and Kim,Y.H. (2008) Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast 

differentiation. Cell Biology and Toxicology, 24, 225-231. 

Bone Marrow Derived Mesenchymal Stem Cells (MSCs) 

Choi,K.M., Seo,Y.K., Yoon,H.H., Song,K.Y., Kwon,S.Y., Lee,H.S. and Park,J.K. (2008) Effect of ascorbic acid on bone 

marrow-derived mesenchymal stem cell proliferation and differentiation. Journal of Bioscience and 

Bioengineering, 105, 586-594. 

Rabbit Autologous Cells from Vaginal Biopsy 

De Philippo,R.E., Bishop,C.E., Freitas Filho,L., Yoo,J.J. and Atala,A. (2008) Tissue Engineering a Complete Vaginal 

Replacement From a Small Biopsy of Autologous Tissue. Transplantation, 86, 208-214. 

Human Fibroblasts from Systemic Sclerotic Patients 

Distler,J.H.W., Akhmetshina,A., Schett,G. and Distler,O. (2008) Monocyte chemoattractant proteins in the 

pathogenesis of systemic sclerosis. Rheumatology, 48, 98-103. 

Atherosclerotic Lesions in Apo-E-Deficient Mice 

Do,G.M., Kwon,E.Y., Kim,H.J., Jeon,S.M., Ha,T.Y., Park,T. and Choi,M.S. (2008) Long-term effects of resveratrol 

supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient 

mice. Biochemical and Biophysical Research Communications, 374, 55-59. 

Rat Lung Tissue 

Elgrabli,D., bella-Gallart,S., Robidel,F., Rogerieux,F., Boczkowski,J. and Lacroix,G. (2008) Induction of apoptosis and 

absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes. 

Toxicology, 253, 131-136. 


Fabre,A., Marchal-Somme,J., Marchand-Adam,S., Quesnel,C., Borie,R., Dehoux,M., Ruffie,C., Callebert,J., Launay,J.M. 

and Henin,D. (2008) Modulation of bleomycin induced lung fibrosis by serotonin receptor antagonists in mice. 

European Respiratory Journal, doi:10.1183/09031936-00126907. 


Failla,M., Genovese,T., Mazzon,E., Fruciano,M., Fagone,E., Gili,E., Barera,A., La Rosa,C., Conte,E., Crimi,N., 

Cuzzocrea, S. and Vaneheri, C. (2008) 16, 16-Dimethyl Prostaglandin E2 Efficacy on Prevention and Protection 

from Bleomycin-induced Lung Injury and Fibrosis. American Journal of Respiratory Cell and Molecular Biology, 

doi:10.1165/rcmb.2007-04380C. 

Mesenchymal Stem Cells 

Fan,H., Liu,H., Toh,S.L. and Goh,J.C.H. (2008) Enhanced differentiation of mesenchymal stem cells co-cultured with 

ligament fibroblasts on gelatin/silk fibroin hybrid scaffold. Biomaterials, 29, 1017-1027. 

Mesenchymal Stem Cells and Silk Scaffold 

Fan,H., Liu,H., Wong,E.J.W., Toh,S.L. and Goh,J.C.H. (2008) In vivo study of anterior cruciate ligament regeneration 

using mesenchymal stem cells and silk scaffold. Biomaterials, 29, 3324-3337.

Murine Intestinal Myofibroblasts 

Fichtner-Feigl,S., Young,C.A., Kitani,A., Geissler,E.K., Schlitt,H.J. and Strober,W. (2008) IL-13 Signaling via IL-13Ra2 

Induces Major Downstream Fibrogenic Factors Mediating Fibrosis in Chronic TNBS Colitis. Gastroenterology, 

135, 2003-2013.e7. 

Bone Marrow Samples 

Freyman, T. (2008) Decellularized bone marrow extracellular matrix. US Patent 7326571. 

Cartilage Tissue 

Furukawa,K.S., Imura,K., Tateishi,T. and Ushida,T. (2008) Scaffold-free cartilage by rotational culture for tissue 

engineering. Journal of Biotechnology, 133, 134-145. 

Collagen Based Scaffolds 

Garcia,Y., Wilkins,B., Collighan,R.J., Griffin,M. and Pandit,A. (2008) Towards development of a dermal rudiment for 

enhanced wound healing response. Biomaterials, 29, 857-868. 

Hepatic Stellate Cells 

Gardi,C., Arezzini,B., Monaco,B., De Montis,M.G., Vecchio,D. and Comporti,M. (2008) F 2-isoprostane receptors on 

hepatic stellate cells. Laboratory Investigation, 88, 124-131. 

ECM Model of Fibroblast Monolayer and Endothelial Cell-Coated Beads 

Ghajar,C.M., Chen,X., Harris,J.W., Suresh,V., Hughes,C.C.W., Jeon,N.L., Putnam,A.J. and George,S.C. (2008) The 

Effect of Matrix Density on the Regulation of 3-D Capillary Morphogenesis. Biophysical Journal, 94, 1930-1941. 

Human Carotid Plaques 

Gonçalves, I., Ares, M.P.S., Moberg, A., Moses, J., To, F., Montan, J., Pedro, L.M., Dias, N., e Fernandes, J.F., 

Fredrikson, G.N., Nilsson, J., Jovinge, S. and Bengtsson, E. (2008) Elastin- and Collagen-Rich Human Carotid 

Plaques Have Increased Levels of the Cysteine Protease Inhibitor Cystatin C. Journal of Vascular Research, 45, 

395 – 401. 

Murine Intestinal Tissue 

Grassl,G.A., Valdez,Y., Bergstrom,K.S.B., Vallance,B.A. and Finlay,B.B. (2008) Chronic Enteric Salmonella Infection in 

Mice Leads to Severe and Persistent Intestinal Fibrosis. Gastroenterology, 134,768-780.e2. 

293 T-Rex Cell Line 

Greenspan,D., Zhang,Y. and GE,G. (2008) Method and composition for treating a fibrotic disorder. WIPO Patent 

Application WO/2008/024767. 

Porcine Valvular Interstitial Cells from Distinct Regions of Mitral Valve 

Gupta,V., Werdenberg,J.A., Mendez,J.S. and Jane Grande-Allen,K. (2008) Influence of strain on proteoglycan synthesis 

by valvular interstitial cells in three-dimensional culture. Acta Biomaterialia, 4, 88-96. 

Porcine Valvular Interstitial Cells from Valve Leaflet and Chordae 

Gupta,V., Werdenberg,J.A., Lawrence,B.D., Mendez,J.S., Stephens,E.H. and Grande-Allen,K.J. (2008) Reversible 

Secretion of Glycosaminoglycans and Proteoglycans by Cyclically Stretched Valvular Cells in 3D Culture. Annals 

of Biomedical Engineering, 36, 1092-1103.

Demineralized Bone Matrix 

Han,B., Yang,Z. and Nimni,M. (2008) Effects of gamma irradiation on osteoinduction associated with demineralized 

bone matrix. Journal of Orthopaedic Research, 26, 75-82. 


Hardie,W.D., Davidson,C., Ikegami,M., Leikauf,G.D., Le Cras,T.D., Prestridge,A., Whitsett,J.A. and Korfhagen,T.R. 

(2008) EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-α-induced pulmonary 

fibrosis. American Journal of Physiology- Lung Cellular and Molecular Physiology, 294, L1217-L1225. 

Rabbit Fibrocartilaginous Tissues 

Hashem,G., Zhang,Q., Hayami,T., Chen,J., Wang,W. and Kapila,S. (2008) Relaxin and β-estradiol modulate targeted 

matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss. Arthritis 

Research and Therapy, 8, R98. 


Hashimoto,S., Amaya,F., Matsuyama,H., Ueno,H., Kikuchi,S., Tanaka,M., Watanabe,Y., Ebina,M., Ishizaka,A. and 

Tsukita,S. (2008) Dysregulation of lung injury and repair in moesin-deficient mice treated with intratracheal 

bleomycin. American Journal of Physiology- Lung Cellular and Molecular Physiology, 295, L566-L574. 

Human Annulus Fibrosus (HAF) Cells 

Helen,W. and Gough,J.E. (2008) Cell viability, proliferation and extracellular matrix production of human annulus 

fibrosus cells cultured within PDLLA/Bioglass® composite foam scaffolds in vitro. Acta Biomaterialia, 4, 230- 

243. 


Hirata,H., Arima,M., Fukushima,Y., Ishii,Y., Tokuhisa,T. and Fukuda,T. (2008) Effects of Th2 pulmonary inflammation 

in mice with bleomycin-induced pulmonary fibrosis. Respirology, 13, 788-798. 

Murine Liver Tissue 

Hisamori,S., Tabata,C., Kadokawa,Y., Okoshi,K., Tabata,R., Mori,A., Nagayama,S., Watanabe,G., Kubo,H. and Sakai,Y. 

(2008) All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through 

modulating cytokine production. Liver International, 28, 1217-1225. 

Rat Mesenchymal Stem Cells and Porcine Aortic Valve Leaflets. 

Hong,H., Dong,G.N., Shi,W.J., Chen,S., Guo,C. and Hu,P. (2008) Fabrication of Biomatrix/Polymer Hybrid Scaffold for 

Heart Valve Tissue Engineering in Vitro. ASAIO Journal, 54, 627-632. 

Murine Dorsum 

Hong,H.J., Jin,S.E., Park,J.S., Ahn,W.S. and Kim,C.K. (2008) Accelerated wound healing by smad3 antisense 

oligonucleotides-impregnated chitosan/alginate polyelectrolyte complex. Biomaterials, 29, 4831-4837. 

Mouse Model of Scleroderma 

Hoyles,R.K., Khan,K., Shiwen,X., Howat,S.L., Lindahl,G.E., Leoni,P., du Bois,R.M., Wells,A.U., Black,C.M. and 

Abraham,D.J. (2008) Fibroblast-Specific Perturbation of Transforming Growth Factor Signaling Provides Insight 

Into Potential Pathogenic Mechanisms of Scleroderma-Associated Lung Fibrosis. Arthritis & Rheumatism, 58, 

1175-1188.

Mouse Cardiac Fibroblasts 

Hu,C., Dandapat,A., Sun,L., Khan,J.A., Liu,Y., Hermonat,P.L. and Mehta,J.L. (2008) Regulation of TGF β1-mediated 

Collagen Formation by LOX-1: Studies Based on Forced Overexpression of TGF β1 in Wild-Type and LOX-1 

Knock-Out Mouse Cardiac Fibroblasts. Journal of Biological Chemistry, 283, 10226-10231. 

Human Cartilage Culture and a Rabbit Model of Osteoarthritis 

Huh,J.E., Baek,Y.H., Ryu,S.R., Lee,J.D., Choi,D.Y. and Park,D.S. (2008) Efficacy and mechanism of action of KHBJ-9B, 

a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit model 

of collagenase-induced osteoarthritis. International Immunopharmacology, 9, 230-240. 

Osteoblasts In Vitro and Calvarial Osteoblasts In Vivo 

Idris,A.I., Rojas,J., Greig,I.R., van’t Hof,R.J. and Ralston,S.H. (2008) Aminobisphosphonates Cause Osteoblast 

Apoptosis and Inhibit Bone Nodule Formation In Vitro. Calcified Tissue International, 82, 191-201. 

Murine Cardiac Tissue 

Inagaki,K., Koyanagi,T., Berry,N.C., Sun,L. and Mochly-Rosen,D. (2008) Pharmacological Inhibition of ε-Protein Kinase C 

Attenuates Cardiac Fibrosis and Dysfunction in Hypertension-Induced Heart Failure. Hypertension, 51, 1565. 

Human Periodontal Ligament Cell Line (HPL) 

Inubushi,T., Tanaka,E., Rego,E.B., Kitagawa,M., Kawazoe,A., Ohta,A., Okada,H., Koolstra,J.H., Miyauchi,M. and 

Takata,T. (2008) Effects of Ultrasound on the proliferation and differentiation of Cementoblast lineage Cells. 

Journal of Periodontology, 79, 1-2. 

Primary Hepatic Stellate Cells from Wild Type and Sept 4-/-Mice 

Iwaisako,K., Hatano,E., Taura,K., Nakajima,A., Tada,M., Seo,S., Tamaki,N., Sato,F., Ikai,I. and Uemoto,S. (2008) Loss 

of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells. Journal of Hepatology, 

49, 768-778. 


Kakizaki,T., Kohno,M., Watanabe,M., Tajima,A., Izumi,Y., Miyasho,T., Tasaka,S., Fukunaga,K., Maruyama,I. and 

Ishizaka,A. (2008) Exacerbation of Bleomycin-Induced Injury and Fibrosis by Pneumonectomy in the Residual 

Lung of Mice. Journal of Surgical Research, doi:10.1016/j.jss.2008.06.021. 


Kang,Y.S., Ko,G.J., Lee,M.H., Song,H.K., Han,S.Y., Han,K.H., Kim,H.K., Han,J.Y. and Cha,D.R. (2008) Effect of 

eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats. 

Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfn448. 

Murine Skin 

Kanno,Y., Kaneiwa,A., Minamida,M., Kanno,M., Tomogane,K., Takeuchi,K., Okada,K., Ueshima,S., Matsuo,O. and 

Matsuno,H. (2008) The Absence of uPAR Is Associated with the Progression of Dermal Fibrosis. Journal of 

Investigative Dermatology, doi:10.1038/jid.2008.157. 

Human Gingival Fibroblasts 

Kim,J.Y., Park,S.H., Cho,K.S., Kim,H.J., Lee,C.K., Park,K.K., Choi,S.H. and Chung,W.Y. (2008) Mechanism of 

Azithromycin Treatment on Gingival Overgrowth. Journal of Dental Research, 87, 1075.

Mouse Primary and NIH/3T3 Fibroblasts 

Kitowska,K., Zakrzewicz,D., Königshoff,M., Chrobak,I., Grimminger,F., Seeger,W., Bulau,P. and Eickelberg,O. (2008) 

Functional role and species-specific contribution of arginases in pulmonary fibrosis. American Journal of 

Physiology- Lung Cellular and Molecular Physiology, 294, L34-L45. 


Ko,G.J., Kang,Y.S., Han,S.Y., Lee,M.H., Song,H.K., Han,K.H., Kim,H.K., Han,J.Y. and Cha,D.R. (2008) Pioglitazone 

attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Nephrology 

Dialysis Transplantation, 23, 2750-2760. 

Lung Epithelial Cells 

Königshoff,M., Balsara,N., Pfaff,E.M., Kramer,M., Chrobak,I., Seeger,W. and Eickelberg,O. (2008) Functional Wnt 

Signaling Is Increased in Idiopathic Pulmonary Fibrosis. PLoS ONE, 3 (5) e2142.doi:1371/journal.pone.0002142. 

Rat Bone Marrow-Derived Mesenchymal Stromal Cells (BMSCs) 

Kwon,D.S., Gao,X., Liu,Y.B., Dulchavsky,D.S., Danyluk,A.L., Bansal,M., Chopp,M., McIntosh,K., Arbab,A.S. and 

Dulchavsky,S.A. (2008) Treatment with bone marrow-derived stromal cells accelerates wound healing in 

diabetic rats. International Wound Journal, 5, 453-463. 

Mouse Osteoblastic MC3T3-E1 Cell Line 

Lee,K.H. and Choi,E.M. (2008) Myricetin, a naturally occurring flavonoid, prevents 2-deoxy-d-ribose induced 

dysfunction and oxidative damage in osteoblastic MC3T3-E1 cells. European Journal of Pharmacology, 591, 1- 

6. 


Lee,K.S., Park,S.J., Kim,S.R., Min,K.H., Lee,K.Y., Choe,Y.H., Hong,S.H., Lee,Y.R., Kim,J.S. and Hong,S.J. (2008) 

Inhibition of VEGF blocks TGF-β1 production through a PI3K/Akt signalling pathway. European Respiratory 

Journal, 31, 523-531. 

Murine Tissue 

Lee,S.J., Van Dyke,M., Atala,A. and Yoo,J.J. (2008) Host Cell Mobilization for In Situ Tissue Regeneration. 

Rejuvenation Research, 11, 747-756. 


Le Saux,O., Teeters,K., Miyasato,S., Choi,J., Nakamatsu,G., Richardson,J.A., Starcher,B., Davis,E.C., Tam,E.K. and 

Jourdan-Le Saux,C. (2008) The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties. 

American Journal of Physiology- Lung Cellular and Molecular Physiology, 295, L1007-L1017. 

Renal Tissue of Zucker Diabetic Fatty Rats 

Li,Y., Qi,Y., Kim,M.S., Xu,K.Z., Huang,T.H., Rong,X., Murray,M. and Yamahara,J. (2008) Increased renal collagen crosslinking 

and lipid accumulation in nephropathy of Zucker diabetic fatty rats. Diabetes Metab Res Rev., 24, 498- 

506. 

Cardiac Fibroblasts 

Lijnen,P., Petrov,V., van Pelt,J. and Fagard,R. (2008) Inhibition of Superoxide Dismutase Induces Collagen Production 

in Cardiac Fibroblasts. American Journal of Hypertension, 21, 1129-1136.

Human Lung Tissue from Patients with Idiopathic Pulmonary Fibrosis and Human Fibroblasts 

Lin,L., Zhou,Z., Zheng,L., Alber,S., Watkins,S., Ray,P., Kaminski,N., Zhang,Y. and Morse,D. (2008) Cross Talk between 

Id1 and Its Interactive Protein Dril1 Mediate Fibroblast Responses to Transforming Growth Factor-β in 

Pulmonary Fibrosis. American Journal of Pathology, 173, 337-346. 

Rat Hepatic Stellate Cell Line (HSC-T6) 

Lin,Y.L., Wu,C.F. and Huang,Y.T. (2008) Effects of rhubarb on migration of rat hepatic stellate cells. Journal of 

Gastroenterology and Hepatology, doi:10.1111/j.1440-1746.2008.05573.x. 

Osteoblasts 

Liu,H., Yazici,H., Ergun,C., Webster,T.J. and Bermek,H. (2008) An in vitro evaluation of the Ca/P ratio for the 

cytocompatibility of nano-to-micron particulate calcium phosphates for bone regeneration. Acta Biomaterialia, 

4, 1472-1479. 

Normal Human Bronchial Epithelial Cells 

Malavia,N.K., Mih,J.D., Raub,C.B., Dinh,B.T., George,S.C., Tirumurugaan,K.G., Kang,B.N., Panettieri,R.A., Foster,D.N. 

and Walseth,T.F. (2008) IL-13 induces a bronchial epithelial phenotype that is profibrotic. Respiratory 

Research, 9, 27. 

Leiomyoma and Myometrial Cells 

Malik,M., Webb,J. and Catherino,W.H. (2008) Retinoic acid treatment of human leiomyoma cells transformed the cell 

phenotype to one strongly resembling myometrial cells. Clinical Endocrinology, 69, 462-470. 

Rat Cardiomyocytes 

Mancuso,P., Rahman,A., Hershey,S.D., Dandu,L., Nibbelink,K.A. and Simpson,R.U. (2008) 1, 25-Dihydroxyvitamin-D3 

Treatment Reduces Cardiac Hypertrophy and Left Ventricular Diameter in Spontaneously Hypertensive Heart 

Failure-prone (cp/+) Rats Independent of Changes in Serum Leptin. Journal of Cardiovascular Pharmacology, 

51, 559-564. 

Murine Model of Plexiform Neurofibroma 

McDaniel,A.S. (2008) The role of PAK1 in the cellular and molecular components of plexiform neurofibromas. 

http://hdl.handle.net/1805/1696 

Human Lung Fibroblasts and Myofibroblasts 

Milam,J.E., Keshamouni,V.G., Phan,S.H., Hu,B., Gangireddy,S.R., Hogaboam,C.M., Standiford,T.J., Thannickal,V.J. 

and Reddy,R.C. (2008) PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycininduced 

pulmonary fibrosis. American Journal of Physiology- Lung Cellular and Molecular Physiology, 294, 

L891-L901. 

Human Retinal Pigment Epithelial (ARPE-19) Cell Line 

Morales,S.A., Mareninov,S., Wadehra,M., Zhang,L., Goodglick,L., Braun,J. and Gordon,L.K. (2008) Epithelial Membrane 

Protein 2 (EMP2) Controls Collagen Gel Contraction in ARPE-19 Cells by Modulating FAK Activation. 

Investigative Ophthalmology & Visual Science, doi:10:1167/iovs.07-1598. 


Mozaffarian,A., Brewer,A.W., Trueblood,E.S., Luzina,I.G., Todd,N.W., Atamas,S.P. and Arnett,H.A. (2008) Mechanisms 

of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis. The Journal of Immunology, 181, 7243.

Human IPF/UIP Fibroblasts 

Murray,L.A., Argentieri,R.L., Farrell,F.X., Bracht,M., Sheng,H., Whitaker,B., Beck,H., Tsui,P., Cochlin,K. and 

Evanoff,H.L. (2008) Hyper-responsiveness of IPF/UIP fibroblasts: Interplay between TGFβ1, IL-13 and CCL2. 

International Journal of Biochemistry and Cell Biology, 40, 2174-2182. 


Murray,L.A., Hackett,T.L., Warner,S.M., Shaheen,F., Argentieri,R.L., Dudas,P., Farrell,F.X. and Knight,D.A. (2008) 

BMP-7 Does Not Protect against Bleomycin-Induced Lung or Skin Fibrosis. PLoS ONE, 3,e4039. 

Bovine Articular Cartilage 

Natoli,R.M., Scott,C.C. and Athanasiou,K.A. (2008) Temporal Effects of Impact on Articular Cartilage Cell Death, Gene 

Expression, Matrix Biochemistry, and Biomechanics. Annals of Biomedical Engineering, 36, 780-792. 

Murine Model of Liver Cirrhosis 

Nishibe,Y., Kaneko,H., Suzuki,H., Abe,T., Matsuura,Y. and Takaku,H. (2008) Baculovirus-mediated interferon alleviates 

dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model. Gene Therapy, 15, 990-997. 

Horse Superficial Digital Flexor Tendon 

Nixon,A.J., Dahlgren,L.A., Haupt,J.L., Yeager,A.E. and Ward,D.L. (2008) Effect of adipose-derived nucleated cell 

fractions on tendon repair in horses with collagenase-induced tendinitis. American Journal of Veterinary 

Research, 69, 928-937. 

Rat Mesenchymal Stem Cells 

Ocarino,N.M., Boeloni,J.N., Goes,A.M., Silva,J.F., Marubayashi,U. and Serakides,R. (2008) Osteogenic differentiation of 

mesenchymal stem cells from osteopenic rats subjected to physical activity with and without nitric oxide 

synthase inhibition. Nitric Oxide, 19,320-325. 

Murine Intestinal Tissue 

Okoshi,K., Kubo,H., Nagayama,S., Tabata,C., Kadokawa,Y., Hisamori,S., Yonenaga,Y., Fujimoto,A., Mori,A. and 

Onodera,H. (2008) All-trans-Retinoic Acid Attenuates Radiation-Induced Intestinal Fibrosis in Mice. Journal of 

Surgical Research, 150, 53-59. 

Normal Human Lung Fibroblast (NHLF) Cells 

Pandey, A., Scarborough, R. M., and Venkatraman, M. S. (2008) Compositions and methods for inhibiting TGF-β. US 

Patent 7314939. 


Park,H.J., Cho,D.H., Kim,H.J., Lee,J.Y., Cho,B.K., Bang,S.I., Song,S.Y., Yamasaki,K., Di Nardo,A. and Gallo,R.L. (2008) 

Collagen Synthesis Is Suppressed in Dermal Fibroblasts by the Human Antimicrobial Peptide LL-37. Journal of 

Investigative Dermatology, doi:10.1038/jid.2008.320. 

Rabbit Mesenchymal Cells 

Park,K.H. and Na,K. (2008) Effect of growth factors on chondrogenic differentiation of rabbit mesenchymal cells 

embedded in injectable hydrogels. Journal of Bioscience and Bioengineering, 106, 74-79. 

Human Mesenchymal Stem Cells 

Richardson,S.M., Hughes,N., Hunt,J.A., Freemont,A.J. and Hoyland,J.A. (2008) Human mesenchymal stem cell 

differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. Biomaterials, 29, 85-93.

Normal Human Lung Fibroblast (NHLF) Cells 

Scarborough, R. M., Pandey, A., and Mehrotra, M. (2008) Compositions and method for inhibiting TGF-β. US Patent 

7361669. 

Lacrimal Gland Extra Cellular Matrix from Healthy (BALB/C) and Diseased (NOD) Mice 

Schenke-Layland,K., Xie,J., Angelis,E., Starcher,B., Wu,K., Riemann,I., MacLellan,W.R. and Hamm-Alvarez,S.F. (2008) 

Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of 

Sjögren's syndrome. Matrix Biology, 27, 53-66. 

Human Anterior Cruciate Ligament Cell and T-Lymphocyte Cultures 

Seo,Y.K., Yoon,H.H., Song,K.Y., Kwon,S.Y., Lee,H.S., Park,Y.S. and Park,J.K. (2008) Increase in cell migration and 

angiogenesis in a composite silk scaffold for tissue-engineered ligaments. Journal of Orthopaedic Research: 

doi:1002/jor.20752. 

Mouse Model of Dermal Fibrosis 

Shibusawa,Y., Negishi,I., Tabata,Y. and Ishikawa,O. (2008) Mouse model of dermal fibrosis induced by one-time 

injection of bleomycin-poly (L-lactic acid) microspheres. Rheumatology, 47, 454-457. 

Several Tumor Cell Lines 

Shimazaki,M. and Kudo,A. (2008) Impaired capsule formation of tumors in periostin-null mice. Biochemical and 

Biophysical Research Communications, 367, 736-742. 


Shofer,S., Badea,C., Qi,Y., Potts,E., Foster,W.M. and Johnson,G.A. (2008) A micro-CT analysis of murine lung 

recruitment in bleomycin-induced lung injury. Journal of Applied Physiology, 105, 669-677. 


Shvedova,A.A., Kisin,E., Murray,A.R., Johnson,V.J., Gorelik,O., Arepalli,S., Hubbs,A.F., Mercer,R.R., Keohavong,P. and 

Sussman,N. (2008) Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, 

fibrosis, oxidative stress, and mutagenesis. American Journal of Physiology- Lung Cellular and Molecular 

Physiology, 295, L552-L565. 

Human Fibroblast Cultures from Healthy Patients and Patients with Systemic Sclerosis (SSC) 

Skhirtladze,C., Distler,O., Dees,C., Akhmetshina,A., Busch,N., Venalis,P., Zwerina,J., Spriewald,B., Pileckyte,M. and 

Schett,G. (2008) Src kinases in systemic sclerosis: Central roles in fibroblast activation and in skin fibrosis. 

Arthritis and Rheumatism, 58, 1475-1484. 

Cultured Mesangial Cells 

Song,H.K., Lee,M.H., Kim,B.K., Park,Y.G., Ko,G.J., Kang,Y.S., Han,J.Y., Han,S.Y., Han,K.H. and Kim,H.K. (2008) 

Visfatin: A New Player in Mesangial Cell Physiology and Diabetic Nephropathy. American Journal of Physiology- 

Renal Physiology, doi:10:1152/ajprenal.90231.2008. 

Osteoblasts 

Souza,D.M., Andrade,A.L., Fabris,J.D., Valério,P., Góes,A.M., Leite,M.F. and Domingues,R.Z. (2008) Synthesis and in 

vitro evaluation of toxicity of silica-coated magnetite nanoparticles. Journal of Non-Crystalline Solids, 354, 

4894-4897.

Primary Cultures of Dermal Papilla Cells, Dermal Sheath Cells and Interfollicular Dermal Fibroblasts from 

Female Temporo-Occipital Scalp 

Stevenson,S., Taylor,A.H., Meskiri,A., Sharpe,D.T. and Thornton,M.J. (2008) Differing responses of human follicular 

and nonfollicular scalp cells in an in vitro wound healing assay: Effects of estrogen on vascular endothelial 

growth factor secretion. Wound Repair and Regeneration, 16, 243-253. 

Dermis Extracellular Matrix 

Sun,W.Q. and Leung,P. (2008) Calorimetric study of extracellular tissue matrix degradation and instability after gamma 

irradiation. Acta Biomaterialia, 4, 817-826. 

Rat Pancreatic Stellate Cells and Rat Pancreatic Acinar Cells 

Tahara,J., Shimizu,K. and Shiratori,K. (2008) Engulfment of Necrotic Acinar Cells by Pancreatic Stellate Cells Inhibits 

Pancreatic Fibrogenesis. Pancreas, 37, 69-74. 


Tourdot,S., Mathie,S., Hussell,T., Edwards,L., Wang,H., Openshaw,P.J.M., Schwarze,J. and Lloyd,C.M. (2008) 

Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior 

allergen sensitization. Clinical & Experimental Allergy, 38, 1016-1024. 

Murine Cardiac Tissue from Transgenic Mice 

Ueno,M., Suzuki,J., Zenimaru,Y., Takahashi,S., Koizumi,T., Noriki,S., Yamaguchi,O., Otsu,K., Shen,W.J. and 

Kraemer,F.B. (2008) Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and 

fibrosis in streptozotocin diabetic mice. American Journal of Physiology- Endocrinology and Metabolism, 294, 

E1109-E1118. 


Walters, D.M. and Kleeberger, S.R. (2008) Mouse Models of Bleomycin-Induced Pulmonary Fibrosis. Current Protocols in 

Pharmacology, doi: 10.1002/0471141755.ph0546s40. 


Wang,C., Abe,S., Matsuda,K., Yu,C., Li,Y., Usuki,J., Azuma,A. and Kudoh,S. (2008) Effects of Gefitinib on Radiationinduced 

Lung Injury in Mice. Journal of Nippon Medical School, 75, 96-105. 

Human Primary Lung Fibroblasts and Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis 

Xia,H., Diebold,D., Nho,R., Perlman,D., Kleidon,J., Kahm,J., Avdulov,S., Peterson,M., Nerva,J. and Bitterman,P. 

(2008) Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with 

idiopathic pulmonary fibrosis. Journal of Experimental Medicine, doi:10.1084/jem.20080001. 


Yamauchi,E., Shoji,S., Nishihara,M., Shimoda,T. and Nishima,S. (2008) Contribution of Lung Fibroblast Migration in the 

Fibrotic Process of Airway Remodelling in Asthma. Allergology International, 57, 73-78. 

Canine Chondrocytes 

Yanez,J.A., Remsberg,C.M., Vega-Villa,K.R., Miranda,N.D., Navas,J., Ohgami,Y., McCormick,D., Hughes,K., Temple,C. 

and Martinez,S.A. (2008) Pharmacological Evaluation of Glyco-Flex® III and its Constituents on Canine 

Chondrocytes. Journal of Medical Sciences, 8, 98-101. 


Zheng,T., Liu,W., Oh,S.Y., Zhu,Z., Hu,B., Homer,R.J., Cohn,L., Grusby,M.J. and Elias,J.A. (2008) IL-13 Receptor α2 

Selectively Inhibits IL-13-Induced Responses in the Murine Lung. The Journal of Immunology, 180, 522-529.

Skin 

Zheng,T., Oh,M.H., Oh,S.Y., Schroeder,J.T., Glick,A.B. and Zhu,Z. (2008) Transgenic Expression of Interleukin-13 in 

the Skin Induces a Pruritic Dermatitis and Skin Remodeling. Journal of Investigative Dermatology, 

doi:10.1038/jid.2008.295. 

2007 

Dermal Fibroblasts 

Ahlfors,J.E.W. and Billiar,K.L. (2007) Biomechanical and biochemical characteristics of a human fibroblast-produced 

and remodeled matrix. Biomaterials, 28, 2183-2191. 

Murine Vascular and Pulmonary Cells 

Ambalavanan,N., LI,P., Bulger,A., Murphy-Ullrich,J., Oparil,S. and Chen,Y.F. (2007) Endothelin-1 Mediates Hypoxia- 

Induced Increases in Vascular Collagen in the Newborn Mouse Lung. Pediatr Res, 61, 559-564. 

Human Uterine Leiomyomas 

Britten,J.L., Malik,M., Payson,M., Norian,J., Joseph,D. and Catherino,W.H. (2007) All-trans retinoic acid regulates 

collagen synthesis in human uterine leiomyomas. Fertility and Sterility, 88, 218. 

Equine Tendon-Derived Fibrillar Collagen Constructs 

Butler,L.M., Metson-Scott,T., Felix,J., Abhyankar,A., Rainger,G.E., Farndale,R.W., Watson,S.P. and Nash,G.B. (2007) 

Sequential adhesion of platelets and leukocytes from flowing whole blood onto a collagen-coated surface: 

Requirement for a GpVI-binding site in collagen. Thromb Haemost, 97, 814-821. 

Rat Lung Tissue 

Chen,C.M., Wang,L.F., Chou,H.C., Lang,Y.D. and Lai,Y.P. (2007) Up-regulation of Connective Tissue Growth Factor in 

Hyperoxia-Induced Lung Fibrosis. Pediatric Research, 62, 128 – 133. 

Murine Osteoblastic MC3T3-E1 Cell Line 

Choi,E.M. (2007) Modulatory effects of luteolin on osteoblastic function and inflammatory mediators in osteoblastic 

MC3T3-E1 cells. Cell Biology International, 31, 870-877. 


Choi,E.M. (2007) Apigenin increases osteoblastic differentiation and inhibits tumor necrosis factor-α-induced 

production of interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells. Pharmazie, 62, 216-220. 

Human Mesenchymal Stem Cells 

Choi,K.M., Yoon,H.H., Seo,Y.K., Song,K.Y., Kwon,S.Y., Lee,H.S., Park,Y.S., Kim,Y.J. and Park,J.K. (2007) Effect of 

essential and nonessential amino acid compositions on the in vitro behavior of human mesenchymal stem cells. 

Korean Journal of Chemical Engineering, 24, 1058-1063. 

Murine Cardiac Fibroblasts 

Colston,J.T., de la Rosa,S.D., Koehler,M., Gonzales,K., Mestril,R., Freeman,G.L., Bailey,S.R. and Chandrasekar,B. 

(2007) Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. American Journal of 

Physiology- Heart and Circulatory Physiology, 293, H1839. 

Rat Hepatic Stellate Cells 

Comporti,M., Signorini,C., Arezzini,B., Vecchio,D., Monaco,B. and Gardi,C. (2007) F2-isoprostanes are not just markers 

of oxidative stress. Free Radical Biology and Medicine, 44, 247-256.

Mouse Lung Tissue 

Denis,O., van den Brûle,S., Heymans,J., Havaux,X., Rochard,C., Huaux,F. and Huygen,K. (2007) Chronic intranasal 

administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyperreactivity 

and remodelling. Immunology, 122, 268-278. 

Human Colonic Myofibroblasts 

Di Sabatino,A., Pender,S.L.F., Jackson,C.L., Prothero,J.D., Gordon,J.N., Picariello,L., Rovedatti,L., Docena,G., 

Monteleone,G. and Rampton,D.S. (2007) Functional Modulation of Crohn’s Disease Myofibroblasts by Anti-Tumor 

Necrosis Factor Antibodies. Gastroenterology, 133, 137-149. 


Digel,I., Kurulgan,E., Linder,P., Kayser,P., Porst,D., Braem,G.J., Zerlin,K., Artmann,G.M. and Artmann,A.T. (2007) 

Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts. Medical 

and Biological Engineering and Computing, 45, 91-97. 

Murine Muscle Samples 

DuBay,D.A., Choi,W., Urbanchek,M.G., Wang,X., Adamson,B., Dennis,R.G., Kuzon Jr,W.M. and Franz,M.G. (2007) 

Incisional Herniation Induces Decreased Abdominal Wall Compliance via Oblique Muscle Atrophy and Fibrosis. 

Ann Surg, 245, 140-146. 

Murine Kidney Samples 

El Chaar,M., Chen,J., Seshan,S.V., Jha,S., Richardson,I., Ledbetter,S.R., Vaughan Jr,E.D., Poppas,D.P. and Felsen,D. 

(2007) Effect of combination therapy with enalapril and the TGF-beta antagonist 1D11 in unilateral ureteral 

obstruction. American Journal of Physiology- Renal Physiology, 292, F1291-F1301. 


Faress,J.A., Nethery,D.E., Kern,E.F.O., Eisenberg,R., Jacono,F.J., Allen,C.L. and Kern,J.A. (2007) Bleomycin Induced 

Pulmonary Fibrosis is Attenuated by a Monoclonal Antibody Targeting HER2. Journal of Applied Physiology, 

103, 2077-2083. 

Murine Colon Samples 

Fichtner-Feigl,S., Fuss,I.J., Young,C.A., Watanabe,T., Geissler,E.K., Schlitt,H.J., Kitani,A. and Strober,W. (2007) 

Induction of IL-13 Triggers TGF-beta1-Dependent Tissue Fibrosis in Chronic 2, 4, 6-Trinitrobenzene Sulfonic 

Acid Colitis. The Journal of Immunology, 178, 5859. 

Leporine Mesenchymal Stem Cells 

Hannouche,D., Terai,H., Fuchs,J.R., Terada,S., Zand,S., Nasseri,B.A., Petite,H., Sedel,L. and Vacanti,J.P. (2007) 

Engineering of implantable cartilaginous structures from bone marrow-derived mesenchymal stem cells. Tissue 

Eng. 13, 87-99. 

Human Embryonic Stem Cells (hESCs) – Cell Lines H9 and BG01V 

Hoben,G.M., Koay,E.J. and Athanasiou,K.A. (2007) Fibrochondrogenesis in Two Embryonic Stem Cell Lines: Effects of 

Differentiation Timelines. Stem Cells, 26, 422- 430. 

Murine Liver Tissues 

Hsu,Y.C., Chiu,Y.T., Cheng,C.C., Wu,C.F., Lin,Y.L. and Huang,Y.T. (2007) Antifibrotic effects of tetrandrine on hepatic 

stellate cells and rats with liver fibrosis. Journal of Gastroenterology and Hepatology, 22, 99-111.

Human Primary Keloid Fibroblast Culture Supernatant 

Hsu,Y.C., Hsiao,M., Chien,Y.W. and Lee,W.R. (2007) Exogenous nitric oxide stimulated collagen type I expression and 

TGF-β1 production in keloid fibroblasts by a cGMP-dependent manner. Nitric Oxide, 16, 258-265. 

Murine Pulmonary Lysates, Macrophage Cell Line RAW 264.7 and Human Normal Lung Fibroblast MRC-5 Cell 

Line 

Hsu,Y.C., Wang,L.F. and Chien,Y.W. (2007) Nitric oxide in the pathogenesis of diffuse pulmonary fibrosis. Free Radical 

Biology and Medicine, 42, 599-607. 

Human Primary Fibroblast Culture and Murine Dermal Tissue Samples 

Huber,L.C., Distler,J.H., Moritz,F., Hemmatazad,H., Hauser,T., Michel,B.A., Gay,R.E., Matucci-Cerinic,M., Gay,S. and 

Distler,O. (2007) Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of 

bleomycin-induced skin fibrosis. Arthritis Rheum, 56, 2755-2764. 

Murine Bladder Tissue 

Imamura,M., Kanematsu,A., Yamamoto,S., Kimura,Y., Kanatani,I., Ito,N., Tabata,Y. and Ogawa,O. (2007) Basic 

fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle 

cells. American Journal of Physiology- Renal Physiology, 293, F1007-F1017. 

Dog Cardiovascular Tissue 

Jugdutt,B.I., Idikio,H. and Uwiera,R.R.E. (2007) Angiotensin receptor blockade and angiotensin-converting-enzyme 

inhibition limit adverse remodeling of infarct zone collagens and global diastolic dysfunction during healing 

after reperfused ST-elevation myocardial infarction. Molecular and Cellular Biochemistry, 303, 27-38. 


Kai,Y., Yoneyama,H., Koyama,J., Hamada,K., Kimura,H. and Matsushima,K. (2007) Treatment with chondroitinase ABC 

alleviates bleomycin-induced pulmonary fibrosis. Medical Molecular Morphology, 40, 128-140. 

Murine Pancreatic Stellate Cells 

Kaku,T., Oono,T., Zhao,H., Gibo,J., Kawabe,K., Ito,T. and Takayanagi,R. (2007) IS-741 Attenuates Local Migration of 

Monocytes and Subsequent Pancreatic Fibrosis in Experimental Chronic Pancreatitis Induced by Dibutyltin 

Dichloride in Rats. Pancreas, 34, 299-309. 

Murine Lung Homogenates 

Kang,H.R., Lee,C.G., Homer,R.J. and Elias,J.A. (2007) Semaphorin 7A plays a critical role in TGF-β1-induced pulmonary 

fibrosis. J. Exp. Med., 204, 1083. 


Kang,H.R., Cho,S.J., Lee,C.G., Homer,R.J. and Elias,J.A. (2007) TGF-beta 1 stimulates pulmonary fibrosis and 

inflammation via a bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. Journal 

of Biological Chemistry, 282, 7723-7732. 


Kanno,Y., Kuroki,A., Okada,K., Tomogane,K., Ueshima,S., Matsuo,O. and Matsuno,H. (2007) α2-Antiplasmin is involved 

in the production of transforming growth factor β1 and fibrosis. Journal of Thrombosis and Haemostasis, 5, 

2266-2273. 

Human Stem Cells 

Kim,S.G., Jeon,C.H., Suh,H., Choe,J.Y. and Shin,I.H. (2007) P-glycoprotein expression in extracellular matrix formation 

of chondrogenic differentiation of human adult stem cells. Cell Biology International, 31, 1042-1048.

Human Myocardial Samples 

Klotz,S., Danser,A.H., Foronjy,R.F., Oz,M.C., Wang,J., Mancini,D., D'Armiento,J. and Burkhoff,D. (2007) The Impact of 

Angiotensin-Converting Enzyme Inhibitor Therapy on the Extracellular Collagen Matrix During Left Ventricular 

Assist Device Support in Patients With End-Stage Heart Failure. Journal of the American College of Cardiology, 

49, 1166. 


Kohan, M., Bader,R., Puxeddu,I., Levi-Schaffer,F., Breuer,R. and Berkman,N. (2007) Enhanced osteopontin expression 

in a murine model of allergen-induced airway remodelling. Clinical & Experimental Allergy, 37, 1444-1454. 

Ovine Mesenchymal Progenitor Cells 

Kunisaki,S.M., Fuchs,J.R., Steigman,S.A. and Fauza,D.O. (2007) A comparative analysis of cartilage engineered from 

different perinatal mesenchymal progenitor cells. Tissue Eng. 13, 2633 – 2644. 

Human Fibroblast Cell Lines 

Lareu,R.R., Arsianti,I., Subramhanya,H.K., Yanxian,P., Raghunath,M. (2007) In vitro enhancement of collagen matrix 

formation and crosslinking for applications in tissue engineering; a preliminary study. Tissue Eng. 13, 385-391. 

Murine Cementoblastic Cell Line, OCCM-30 

La-Bona,D.A., Tanaka,E., Inubushi,T., Oka,H., Ohta,A., Okada,H., Miyauchi,M., Takata,T. and Tanne,K. (2007) 

Cementoblast response to low-and high-intensity ultrasound. Archives of Oral Biology, 53, 318-323. 

Ovine Bone Marrow Mesenchymal Cells 

Luo,Z.J. and Seedhom,B.B. (2007) Light and low-frequency pulsatile hydrostatic pressure enhances extracellular matrix 

formation by bone marrow mesenchymal cells: an in-vitro study with special reference to cartilage repair. 

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 221, 499- 

507. 


Maret,M., Ruffie,C., Periquet,B., Campo,A.M., Menevret,M., Phelep,A., Dziewiszek,K., Druilhe,A. and Pretolani,M. 

(2007) Liposomal Retinoic Acids Modulate Asthma Manifestations in Mice. Journal of Nutrition, 137, 2730 – 

2736. 

Murine Dermal Biopsies 

Matsushita,T., Fujimoto,M., Hasegawa,M., Matsushita,Y., Komura,K., Ogawa,F., Watanabe,R., Takehara,K. and Sato,S. 

(2007) BAFF Antagonist Attenuates the Development of Skin Fibrosis in Tight-Skin Mice. Journal of Investigative 

Dermatology, 127, 2772-2780. 


Mishra,A., Wang,M., Schlotman,J., Nikolaidis,N.M., DeBrosse,C.W., Karow,M.L. and Rothenberg,M.E. (2007) Resistinlike 

molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine 

lung. American Journal of Physiology- Lung Cellular and Molecular Physiology, 293, L305. 


Misson,P., Brombacher,F., Delos,M., Lison,D. and Huaux,F. (2007) Type 2 immune response associated with silicosis is 

not instrumental in the development of the disease. American Journal of Physiology- Lung Cellular and 

Molecular Physiology, 292, L107-L113.

Murine Bronchoalveolar Lavage Fluid 

Morschl,E., Volmer,J.B., Molina,J.G., Lee,J.J., Ochkur,S.I. and Blackburn,M.R. (2007) A3 Adenosine Receptors 

Modulate Eosinophil Function In Bleomycin-Induced Lung Injury. The Journal of Allergy and Clinical 

Immunology, 119, 218. 

Murine Fibroblast NIH3T3 Cell Line 

Nishi,Y., Sano,H., Kawashima,T., Okada,T., Kuroda,T., Kikkawa,K., Kawashima,S., Tanabe,M., Goto,T. and 

Matsuzawa,Y. (2007) Role of Galectin-3 in Human Pulmonary Fibrosis. Allergology International, 1, 57-65. 


Niu,N., Le Goff,M.K., Li,F., Rahman,M., Homer,R.J. and Cohn,L. (2007) A Novel Pathway That Regulates Inflammatory 

Disease in the Respiratory Tract. The Journal of Immunology, 178, 3846. 


Nomiyama,Y., Tashiro,M., Yamaguchi,T., Watanabe,S., Taguchi,M., Asaumi,H., Nakamura,H. and Otsuki,M. (2007) High 

Glucose Activates Rat Pancreatic Stellate Cells Through Protein Kinase C and p38 Mitogen-Activated Protein 

Kinase Pathway. Pancreas, 34, 364-372. 

Human Epithelial Cells 

Ornatowski,W., Poschet,J.F., Perkett,E., Taylor-Cousar,J.L. and Deretic,V. (2007) Elevated furin levels in human cystic 

fibrosis cells result in hypersusceptibility to exotoxin A induced cytotoxicity. Journal of Clinical Investigation, 

117, 3489. 

Murine Primary Osteoblasts 

Orriss,I.R., Utting,J.C., Brandao-Burch,A., Colston,K., Grubb,B.R., Burnstock,G. and Arnett,T.R. (2007) Extracellular 

Nucleotides Block Bone Mineralization in Vitro: Evidence for Dual Inhibitory Mechanisms Involving Both P2Y2 

Receptors and Pyrophosphate. Endocrinology, 148, 4208. 

Murine Pulmonary Tissue 

Pena,A.M., Fabre,A., Débarre,D., Marchal-Somme,J., Crestani,B., Martin,J.L., Beaurepaire,E. and Schanne-Klein,M.C. 

(2007) Three-dimensional investigation and scoring of extracellular matrix remodeling during lung fibrosis using 

multiphoton microscopy. Microsc.Res.Tech. 70, 162 – 170. 


Pilling,D., Roife,D., Wang,M., Ronkainen,S.D., Crawford,J.R., Travis,E.L. and Gomer,R.H. (2007) Reduction of 

Bleomycin-Induced Pulmonary Fibrosis by Serum Amyloid P. The Journal of Immunology, 179, 4035. 

Human Primary Fetal and Postnatal Dermal Fibroblasts 

Rolfe,K., Grobbelaar,A.O. and Linge,C. (2007) Is TGF-B1 signalling active in fetuses? Journal of Plastic, Reconstructive 

& Aesthetic Surgery, 60, S11. 

Human Fetal and Postnatal Fibroblasts 

Rolfe,K.J., Richardson,J., Vigor,C., Irvine,L.M., Grobbelaar,A.O. and Linge,C. (2007) A Role for TGF-bold italic beta 1- 

Induced Cellular Responses during Wound Healing of the Non-Scarring Early Human Fetus? Journal of 

Investigative Dermatology, 127, 2656-2667.

Ovine Blood-Derived Endothelial Progenitor Cells 

Sales,V.L., Engelmayr Jr,G.C., Johnson Jr,J.A., Gao,J., Wang,Y., Sacks,M.S. and Mayer Jr,J.E. (2007) Protein 

Precoating of Elastomeric Tissue-Engineering Scaffolds Increased Cellularity, Enhanced Extracellular Matrix 

Protein Production, and Differentially Regulated the Phenotypes of Circulating Endothelial Progenitor Cells. 

Circulation, 116, 155-163. 

Rat Choloangiocytes 

Sato,Y., Harada,K., Ozaki,S., Furubo,S., Kizawa,K., Sanzen,T., Yasoshima,M., Ikeda,H., Sasaki,M. and Nakanuma,Y. 

(2007) Cholangiocytes with Mesenchymal Features Contribute to Progressive Hepatic Fibrosis of the Polycystic 

Kidney Rat. American Journal of Pathology, 171, 1859 – 1871. 

Equine Flexor Digitorum Superficialis Tendon (SDFT) Explants 

Schnabel,L.V., Mohammed,H.O., Miller,B.J., McDermott,W.G., Jacobson,M.S., Santangelo,K.S. and Fortier,L.A. (2007) 

Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. 

J Orthop Res, 25, 230-240. 


Shvedova,A.A., Kisin,E.R., Murray,A.R., Gorelik,O., Arepalli,S., Castranova,V., Young,S.H., Gao,F., Tyurina,Y.Y., 

Oury,T.D. and Kagan,V.E. (2007) Vitamin E deficiency enhances pulmonary inflammatory response and 

oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice. Toxicology and Applied 

Pharmacology, 221, 339-348. 

Murine Lung Homogenate 

Swain,S.D., Han,S., Harmsen,A., Shampeny,K. and Harmsen,A.G. (2007) Pulmonary Hypertension Can Be a Sequela of 

Prior Pneumocystis Pneumonia. American Journal of Pathology, 171, 790-799. 

Murine Sponge Implants 

Tkalcević,V.I., Cuzić,S., Brajsa,K., Mildner,B., Bokulić,A., Situm,K., Perović,D., Glojnarić,I. and Parnham,M.J. (2007) 

Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of 

egr-1 expression. European Journal of Pharmacology, 570, 212-221. 


Vittal,R., Zhang,H., Han,M.L.K., Moore,B.B., Horowitz,J.C. and Thannickal,V.J. (2007) Effects of the Protein Kinase 

Inhibitor, Imatinib Mesylate, on Epithelial/Mesenchymal Phenotypes: Implications for Treatment of Fibrotic 

Diseases. Journal of Pharmacology and Experimental Therapeutics, 321, 35-44. 


Wallach-Dayan,S.B., Golan-Gerstl,R. and Breuer,R. (2007) Evasion of myofibroblasts from immune surveillance: A 

mechanism for tissue fibrosis. Proceedings of the National Academy of Sciences, 104, 20460. 

Leporine Chondrocyte 

Xie,J.U.N., Han,Z., Kim,S.O.O.H., Kim,Y.H.A. and Takehisa Matsuda,P.D. (2007) Mechanical Loading-Dependence of 

mRNA Expressions of Extracellular Matrices of Chondrocytes Inoculated into Elastomeric Microporous Poly (Llactide-co-e-caprolactone) 

Scaffold. Tissue Engineering, 13, 29-40. 

Bovine Decellularised Vocal Fold Lamina and Human Vocal Fold Fibroblast Primary Culture 

Xu,C.C., Chan,R.W. and Tirunagari,N. (2007) A Biodegradable, Acellular Xenogeneic Scaffold for Regeneration of the 

Vocal Fold Lamina Propria. Tissue Engineering, 13, 551-566.

Murine Dermal Biopsy 

Yamamoto,T., Yokozeki,H. and Nishioka,K. (2007) Fas-and FasL-deficient mice are resistant to the induction of 

bleomycin-induced scleroderma. Archives of Dermatological Research, 298, 465-468. 

Murine Dermal Tissue 

Yoshioka,T., Imura,K., Hikita,I., Hirasawa,T., Sakata,T., Matsutani,T., Horikawa,T. and Arimura,A. (2007) Impact of Tcell 

receptor V haplotypes on the development of dermatitis in DS-Nh mice: synergistic production of 

interleukin-13 caused by staphylococcal enterotoxin C and peptide glycans from Staphylococcus aureus. 

Immunology, 121, 51-61. 

2006 

Murine Pacreatic Stellate Cells 

Asaumi,H., Watanabe,S., Taguchi,M., Tashiro,M., Nagashio,Y., Nomiyama,Y., Nakamura,H. and Otsuki,M. (2006) Green 

tea polyphenol (-)-epigallocatechin-3-gallate inhibits ethanol-induced activation of pancreatic stellate cells. 

European Journal of Clinical Investigation, 36, 113-122. 

Leporine cartilage and Chondrocyte Explants 

Baek,Y.H., Huh,J.E., Lee,J.D., Choi,D.Y. and Park,D.S. (2006) Effect of Aralia cordata Extracts on Cartilage Protection 

and Apoptosis Inhibition. Biological & Pharmaceutical Bulletin, 29, 1423-1430. 

Porcine Aortic Valves 

Balachandran,K., Konduri,S., Sucosky,P., Jo,H. and Yoganathan,A.P. (2006) An Ex Vivo Study of the Biological 

Properties of Porcine Aortic Valves in Response to Circumferential Cyclic Stretch. Annals of Biomedical 

Engineering, 34, 1655-1665. 

Human Articular Chondrocytes 

Banu,N., Tsuchiya,T. and Sawada,R. (2006) Effects of a biodegradable polymer synthesized with inorganic tin on the 

chondrogenesis of human articular chondrocytes. J Biomed Mater Res A. 77, 84-89. 

Murine Collagen Deposition on Polypropylene Tapes 

Bogusiewicz,M., Wrobel,A., Jankiewicz,K., Adamiak,A., Skorupski,P., Tomaszewski,J. and Rechberger,T. (2006) 

Collagen deposition around polypropylene tapes implanted in the rectus fascia of female rats. European 

Journal of Obstetrics & Gynecology and Reproductive Biology, 124, 106-109. 

Human Ventricular Tissue Samples 

Bruggink,A.H., van Oosterhout,M.F.M., de Jonge,N., Ivangh,B., van Kuik,J., Voorbij,R.H.A.M., Cleutjens,J.P.M., 

Gmelig-Meyling,F.H.J. and de Weger,R.A. (2006) Reverse Remodeling of the Myocardial Extracellular Matrix 

After Prolonged Left Ventricular Assist Device Support Follows a Biphasic Pattern. Journal of Heart and Lung 

Transplantation, 25, 1091-1098. 


Chan,E.S.L., Fernandez,P., Merchant,A.A., Montesinos,M.C., Trzaska,S., Desai,A., Tung,C.F., Khoa,D.N., Pillinger,M.H. 

and Reiss,A.B. (2006) Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal 

fibroblasts and in a murine model of scleroderma. Arthritis & Rheumatism, 54, 2632-2642. 

Murine Lung Samples 

Cho,S.J., Kang,M.J., Homer,R.J., Kang,H.R., Zhang,X., Lee,P.J., Elias,J.A. and Lee,C.G. (2006) Role of Early Growth 

Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling. Journal of Biological Chemistry, 

281, 8161.

Leporine Articular Cartilage 

Cho,Y.J., Huh,J.E., Kim,D.Y., Kim,N.J., Lee,J.D., Baek,Y.H., Cho,E.M., Yang,H.R., Choi,D.Y. and Park,D.S. (2006) 

Effect of Betula platyphylla var. japonica on Proteoglycan Release, Type II Collagen Degradation, and Matrix 

Metalloproteinase Expression in Rabbit Articular Cartilage Explants. Biological & Pharmaceutical Bulletin, 29, 

1408-1413. 

Murine Hepatic Stellate Cells HSC-T6 and Liver Samples 

Chong,L.W., Hsu,Y.C., Chiu,Y.T., Yang,K.C. and Huang,Y.T. (2006) Anti-Fibrotic Effects of Thalidomide on Hepatic 

Stellate Cells and Dimethylnitrosamine-Intoxicated Rats. Journal of Biomedical Science, 13, 403-418. 


Chou,W-Y., Lu,C-n., Lee,T-h., Wu,C-l., Hung,K-s., Concejero,A.M., Jawan,B. and Wang,C-h. (2006) Electroporative 

interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and TIMP 

modulation. Acta Pharmacologica Sinica 27, 469-476. 

Murine Bronchial Lavages 

Chunn,J.L., Mohsenin,A., Young,H.W.J., Lee,C.G., Elias,J.A., Kellems,R.E. and Blackburn,M.R. (2006) Partially 

adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations. 

American Journal of Physiology- Lung Cellular and Molecular Physiology, 290, 579-587. 


Distler,J.H., Jüngel,A., Caretto,D., Schulze-Horsel,U., Kowal-Bielecka,O., Gay,R.E., Michel,B.A., Müller-Ladner,U., 

Kalden,J.R., Gay,S. and Distler,O. (2006) Monocyte chemoattractant protein 1 released from 

glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T 

cells. Arthritis Rheum, 54, 214-225. 


Distler,J.H., Jüngel,A., Huber,L.C., Schulze-Horsel,U., Zwerina,J., Gay,R.E., Michel,B.A., Hauser,T., Schett,G. and 

Gay,S. (2006) Imatinib mesylate reduces production of extracellular matrix and prevents development of 

experimental dermal fibrosis. Arthritis Rheum, 56, 311-322. 

Murine Abdominal Wall Samples 

DuBay,D.A., Wang,X., Adamson,B., Kuzon,W.M., Dennis,R.G. and Franz,M.G. (2006) Mesh incisional herniorrhaphy 

increases abdominal wall elastic properties: A mechanism for decreased hernia recurrences in comparison with 

suture repair. Surgery, 140, 14-24. 

Human Normal and Keloid Fibroblasts 

Duong,H.S., Zhang,Q.Z., Le,A.D., Kelly,A.P., Kamdar,R. and Messadi,D.V. (2006) Elevated prolidase activity in keloids: 

correlation with type I collagen turnover. Br J Dermatol 154, 820-828. 

Ovine Bone Marrow-Derived Mesenchymal Stem Cells 

Engelmayr Jr,G.C., Sales,V.L., Mayer Jr,J.E. and Sacks,M.S. (2006) Cyclic flexure and laminar flow synergistically 

accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications for engineered heart 

valve tissues. Biomaterials, 27, 6083-6095. 


Fichtner-Feigl,S., Strober,W., Kawakami,K., Puri,R.K. and Kitani,A. (2006) IL-13 signaling through the IL-13α2 receptor 

is involved in induction of TGF-β production and fibrosis. Nature Medicine, 12, 99-106.


Fujimoto, H., Gabazza, E. C., Taguchi, O., Nishii, Y., Nakahara, H., Bruno, N. E., Alessandro-Gabazza, C. N., Kasper, 

M., Yano, Y., and Nagashima, M. (2006) Thrombin-Activatable Fibrinolysis Inhibitor Deficiency Attenuates 

Bleomycin-Induced Lung Fibrosis. American Journal of Pathology 168, 1086-1096. 

Porcine Aortic Smooth Muscle Cells 

Gavish,L., Perez,L. and Gertz,S.D. (2006) Low-level laser irradiation modulates matrix metalloproteinase activity and 

gene expression in porcine aortic smooth muscle cells. Lasers Surg Med., 38, 779-786. 

Porcine Bone Marrow Stromal Cells 

Goh,J.C.H., Te Tay,P.D. and Sl Toh,P.D. (2006) Characterization of a Novel Polymeric Scaffold for Potential Application 

in Tendon/Ligament Tissue Engineering. Tissue Engineering, 12, 91-99. 

Murine Mesangial and Proximal Tubular Cell Culture Supernatants 

Han,K.H., Kang,Y.S., Han,S.Y., Jee,Y.H., Lee,M.H., Han,J.Y., Kim,H.K., Kim,Y.S. and Cha,D.R. (2006) Spironolactone 

ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats. Kidney 

International, 70, 111-120. 

Human Kidney-2 Cell Culture Supernatants 

Han,S.Y., Jee,Y.H., Han,K.H., Kang,Y.S., Kim,H.K., Han,J.Y., Kim,Y.S. and Cha,D.R. (2006) An imbalance between 

matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development 

of early diabetic nephropathy. Nephrology Dialysis Transplantation, 21, 2406. 

Human Keratinocyte and Fibroblast Artificial Dermis 

Harrison,C.A., Gossiel,F., Layton,C.M., Bullock,A.J., Johnson,T., Ubrey Blumsohn,P.D. and Sheila Macneil,P.D. (2006) 

Use of an in Vitro Model of Tissue-Engineered Skin to Investigate the Mechanism of Skin Graft Contraction. 

Tissue Engineering, 12, 3119-3113. 

Leporine Temporomandibular Joint Disc Fibrocartilage, Knee Meniscus Fibrocartilage, Knee Articular 

Cartilage and Pubic Symphysis 

Hashem,G., Zhang,Q., Hayami,T., Chen,J., Wang,W. and Kapila,S. (2006) Relaxin and β-estradiol modulate targeted 

matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss. Arthritis Res 

Ther., 8, R98. 

Equine Superficial Digital Flexor Tendon in Explant Culture 

Haupt,JL., Donnelly,BP. and Nixon,AJ. (2006) Effects of platelet-derived growth factor-BB on the metabolic function 

and morphologic features of equine tendon in explants culture. Am J Vet Res, 67, 1595-1600. 

Human Osteoblast-Like SaOS-2 Cell Line 

Huh,J.E., Yang,H.R., Park,D.S., Choi,D.Y., Baek,Y.H., Cho,E.M., Cho,Y.J., Kang-Il,K., Kim,D.Y. and Lee,J.D. (2006) 

Puerariae radix promotes differentiation and mineralization in human osteoblast-like SaOS-2 cells. J 

Ethnopharmacol, 104, 345-350. 

Murine Pulmonary Myofibroblasts 

Izumi,N., Mizuguchi,S., Inagaki,Y., Saika,S., Kawada,N., Nakajima,Y., Inoue,K., Suehiro,S., Friedman,S.L. and Ikeda,K. 

(2006) BMP-7 opposes TGF-β1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2. 

American Journal of Physiology- Lung Cellular and Molecular Physiology, 290, 120-126.


Jacono,F.J., Peng,Y.J., Nethery,D., Faress,J.A., Lee,Z., Kern,J.A. and Prabhakar,N.R. (2006) Acute lung injury 

augments hypoxic ventilatory response in the absence of systemic hypoxemia. Journal of Applied Physiology, 

101, 1795. 


Kato,T., Okahashi,N., Ohno,T., Inaba,H., Kawai,S. and Amano,A. (2006) Effect of phenytoin on collagen accumulation 

by human gingival fibroblasts exposed to TNF-ain vitro. Oral Diseases, 12, 156-162. 

Human Alveolar Epithelial (A549) and Akata Cell Lines 

Keating,D.T., Sadlier,D.M., Patricelli,A., Smith,S.M., Walls,D., Egan,J.J. and Doran,P.P. (2006) Microarray identifies 

ADAM family members as key responders to TGF-beta 1 in alveolar epithelial cells. Respiratory Research, 7, 

114. 

Murine Kidneys 

Kellner,D., Chen,J., Richardson,I., Seshan,S.V., EL Chaar,M., Vaughan Jr,E.D., Poppas,D. and Felsen,D. (2006) 

Angiotensin receptor blockade decreases fibrosis and fibroblast expression in a rat model of unilateral ureteral 

obstruction. J Urol, 176, 806-812. 

Murine Kidney Cortex 

Kushibiki,T., Nagata-Nakajima,N., Sugai,M., Shimizu,A. and Tabata,Y. (2006) Enhanced anti-fibrotic activity of plasmid 

DNA expressing small interference RNA for TGF-beta type II receptor for a mouse model of obstructive 

nephropathy by cationized gelatin prepared from different amine compounds. J Control Release, 110, 610- 

617. 

Murine Tracheal Homogenates 

Lama,V.N., Harada,H., Badri,L.N., Flint,A., Hogaboam,C.M., McKenzie,A., Martinez,F.J., Toews,G.B., Moore,B.B. and 

Pinsky,D.J. (2006) Obligatory Role for Interleukin-13 in Obstructive Lesion Development in Airway Allografts. 

American Journal of Pathology, 169, 47. 

Human ER-Positive Breast Cancer MCF-7 Cell Line and Murine Osteoblast-Like MC3T3-E1 Cell Line 

Lee,K.H. and Choi,E.M. (2006) Stimulatory effects of extract prepared from the bark of Cinnamomum cassia blume on 

the function of osteoblastic MC3T3-E1 cells. Phytother.Res, 20, 952-960. 

Murine Osteoblast-Like MC3T3-E1 Cell Line 

Lee,K.H. and Choi,E.M. (2006) Rubus coreanus Miq. Extract Promotes Osteoblast Differentiation and Inhibits Bone- 

Resorbing Mediators in MC3T3-E1 Cells. The American Journal of Chinese Medicine, 34, 643-654. 


Lee,K.S., Park,S.J., Kim,S.R., Min,K.H., Jin,S.M., Lee,H.K. and Lee,Y.C. (2006) Modulation of Airway Remodeling and 

Airway Inflammation by Peroxisome Proliferator-Activated Receptor γ in a Murine Model of Toluene 

Diisocyanate-Induced Asthma. The Journal of Immunology, 177, 5248. 


Lee,T.H., Jawan,B., Chou,W.Y., Lu,C.N., Wu,C.L., Kuo,H.M., Concejero,A.M. and Wang,C.H. (2006) alpha-Melanocytestimulating 

hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice. J Gene Med, 8, 

764-772.


Lee,J.H., Roh,M.R. and Lee,K.H. (2006) Effects of Infrared Radiation on Skin Photo-Aging and Pigmentation. Yonsei 

Med J., 47, 485-490. 

Murine Bone Marrow Stromal Cells and Osteoblasts 

Leivo,J., Meretoja,V., Vippola,M., Levanen,E., Vallittu,P. and Mantyla,T.A. (2006) Sol-gel derived aluminosilicate 

coatings on alumina as substrate for osteoblasts. Acta Biomater. 2, 659-668. 

Human Skin Fibroblasts 

Li,B., Chen,J. and James,H.C.W. (2006) RGD peptide-conjugated poly (dimethylsiloxane) promotes adhesion, 

proliferation, and collagen secretion of human fibroblasts. Mater Res, 79, 989-998. 

Murine Cardiac Fibroblasts 

Lijnen,P., Papparella,I., Petrov,V., Semplicini,A. and Fagard,R. (2006) Angiotensin II-stimulated collagen production in 

cardiac fibroblasts is mediated by reactive oxygen species. J Hypertens, 24, 757-766. 

Murine Hepatocytes and Hepatic Stellate Cells 

Lin,Y.L., Wu,C.H., Luo,M.H., Huang,Y.J., Wang,C.N., Shiao,M.S. and Huang,Y.T. (2006) In vitro protective effects of 

salvianolic acid B on primary hepatocytes and hepatic stellate cells. Journal of Ethnopharmacology, 105, 215- 

222. 


Liu,H., Liu,L., Fletcher,B.S. and Visner,G.A. (2006) Sleeping Beauty-based gene therapy with indoleamine 2, 3dioxygenase 

inhibits lung allograft fibrosis. The FASEB Journal, 20, 2384. 


Lopez,E., del Pozo,V., Miguel,T., Sastre,B., Seoane,C., Civantos,E., Llanes,E., Baeza,M.L., Palomino,P. and Cardaba,B. 

(2006) Inhibition of Chronic Airway Inflammation and Remodeling by Galectin-3 Gene Therapy in a Murine 

Model 1. The Journal of Immunology, 176, 1943-1950. 


Ma,B., Blackburn,M.R., Lee,C.G., Homer,R.J., Liu,W., Flavell,R.A., Boyden,L., Lifton,R.P., Sun,C.X. and Young,H.W. 

(2006) Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. 

Journal of Clinical Investigation, 116, 1274-1283. 

Human Dermal Fibroblast Primary and CRL-2127 Cell Cultures 

Makareeva,E., Cabral,W.A., Marini,J.C. and Leikin,S. (2006) Molecular Mechanism of Alpha 1(I)-Osteogenesis 

Imperfecta/Ehlers-Danlos Syndrome: Unfolding of an N-Anchor Domain at the N-Terminal End of the Type I 

Collagen Triple Helix. Journal of Biological Chemistry, 281, 6463. 


Manoury,B., Nenan,S., Guenon,I., Boichot,E., Planquois,J.M., Bertrand,C.P. and Lagente,V. (2006) Macrophage 

metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice. J Inflamm 

(Lond), 3, 2. 


McFarlin,K., Gao,X., Liu,Y.B., Dulchavsky,D.S., Kwon,D., Arbab,A.S., Bansal,M., Li,Y., Chopp,M. and Dulchavsky,S.A. 

(2006) Bone marrow-derived mesenchymal stromal cells accelerate wound healing in the rat. Wound Repair 

and Regeneration, 14, 471-478.

Leporine Bone Marrow-Derived Mesenchymal Stem Cells 

Medrado,G.C.B., Machado,C.B., Valerio,P., Sanches,M.D. and Goes,A.M. (2006) The effect of a chitosan-gelatin matrix 

and dexamethasone on the behavior of rabbit mesenchymal stem cells. Biomedical Materials, 1, 155-161. 

Murine Rectal Tissue 

Motomura,Y., Khan,W.I., El-Sharkawy,R.T., Verma-Gandhu,M., Verdu,E.F., Gauldie,J. and Collins,S.M. (2006) Induction 

of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1. Gut, 55, 

662-670. 

Human Lung Fibroblastic Cell Line TIG-3-20 

Nagano, J., Iyonaga, K., Kawamura, K., Yamashita, A., Ichiyasu, H., Okamoto, T., Suga, M., Sasaki, Y., and Kohrogi, H. 

(2006) Use of tacrolimus, a potent antifibrotic agent, in bleomycin-induced lung fibrosis. European Respiratory 

Journal, 27, 460-469. 


Narita,Y., Nomura,J., Ohta,S., Inoh,Y., Suzuki,K.M., Araki,Y., Okada,S., Matsumoto,I., Isohama,Y. and Abe,K. (2006) 

Royal Jelly Stimulates Bone Formation: Physiologic and Nutrigenomic Studies with Mice and Cell Lines. 

Bioscience, Biotechnology, and Biochemistry, 70, 2508-2514. 


Oikonomou,N., Harokopos,V., Zalevsky,J., Valavanis,C., Kotanidou,A., Szymkowski,D.E., Kollias,G. and Aidinis,V. 

(2006) Soluble TNF Mediates the Transition from Pulmonary Inflammation to Fibrosis. PLoS ONE, 1, e108. 

Murine Osteoblast Primay Cultures 

Oktar,F.N., Valério,P., Goller,G., Agathopoulos,S., Goes,A.M. and Leite,M.F. (2006) Biocompatibility of the Outer 

Prismatic and the Inner Nacreous Layers of Four Different Molluscs. Key Engineering Materials, 309, 449. 

Human Ligament Fibroblasts Primary Culture 

Park,S.A., Kim,I.A., Lee,Y.J., Shin,J.W., Kim,C.R., Kim,J.K., Yang,Y.I. and Shin,J.W. (2006) Biological Responses of 

Ligament Fibroblasts and Gene Expression Profiling on Micropatterned Silicone Substrates Subjected to 

Mechanical Stimuli. Journal of Bioscience and Bioengineering, 102, 402-412. 

Murine Hepatic Stellate Cells 

Patella,S., Phillips,D.J., Tchongue,J., de Kretser,D.M. and Sievert,W. (2006) Follistatin attenuates early liver fibrosis: 

effects on hepatic stellate cell activation and hepatocyte apoptosis. American Journal of Physiology- 

Gastrointestinal and Liver Physiology, 290, 137-144. 

Human Fibroblast HFL-1 and Epithelial A549 Cell Line Co-Cultures 

Phillips,R.J., Blatt,L.M. and Ozes,O.N. (2006) Pirfenidone and Interferon Gamma-1b Inhibit the Profibrotic Effects of 

Osteopontin. Chest, 130, 229S. 


Polte,T., Foell,J., Werner,C., Hoymann,H.G., Braun,A., Burdach,S., Mittler,R.S. and Hansen,G. (2006) CD137-mediated 

immunotherapy for allergic asthma. Journal of Clinical Investigation, 116, 1025-1036. 

Human Mesenchymal Populations and Articular Chondrocytes 

Pound,J.C., Green,D.W., Chaudhuri,J.B., Mann,S., Roach,H.I. and Oreffo,R.O.C. (2006) Strategies to Promote 

Chondrogenesis and Osteogenesis from Human Bone Marrow Cells and Articular Chondrocytes Encapsulated in 

Polysaccharide Templates. Tissue Engineerig, 12, 2789-2799.

Murine Cardiac Tissue 

Reyes,M., Steinhelper,M.E., Alvarez,J.A., Escobedo,D., Pearce,J., Valvano,J.W., Pollock,B.H., Wei,C.L., Kottam,A. and 

Altman,D. (2006) Impact of physiological variables and genetic background on myocardial frequency-resistivity 

relations in the intact beating murine heart. American Journal of Physiology- Heart and Circulatory Physiology, 

291, H1659. 

Murine Fibroblast and Macrophage Co-Cultures 

Saika, S., Ikeda, K., Yamanaka, O., Flanders, K. C., Okada, Y., Miyamoto, T., Kitano, A., Ooshima, A., Nakajima, Y., 

and Ohnishi, Y. (2006) Loss of Tumor Necrosis Factor α Potentiates Transforming Growth Factor β-mediated 

Pathogenic Tissue Response During Wound Healing. American Journal of Pathology 168, 1848-1860. 

Ovine Blood-Derived Endothelial Progenitor Cells 

Sales,V.L., Engelmayr Jr,G.C., Mettler,B.A., Johnson Jr,J.A., Sacks,M.S. and Mayer Jr,J.E. (2006) Transforming Growth 

Factor-β1 Modulates Extracellular Matrix Production, Proliferation, and Apoptosis of Endothelial Progenitor 

Cells in Tissue-Engineering Scaffolds. Circulation, 114, 1193-1199. 


Sato,Y., Harada,K., Furubo,S., Kizawa,K., Sanzen,T., Yasoshima,M., Ozaki,S., Isse,K., Sasaki,M. and Nakanuma,Y. 

(2006) Inhibition of Intrahepatic Bile Duct Dilation of the Polycystic Kidney Rat with a Novel Tyrosine Kinase 

Inhibitor Gefitinib. American Journal of Pathology, 169, 1238. 

Porcine Cardiac Valve Leaflets 

Schenke-Layland, K., Madershahian, N., Riemann, I., Starcher, B., Halbhuber, K. J., Konig, K., and Stock, U. A. Impact 

of Cryopreservation on Extracellular Matrix Structures of Heart Valve Leaflets. The Annals of Thoracic Surgery 

81, 918-926. 

Human Primary Fibroblast Cultures from Scleroderma Patients 

Sherriff-Tadano,R., Ohta,A., Morito,F., Mitamura,M., Haruta,Y., Koarada,S., Tada,Y., Nagasawa,K. and Ozaki,I. (2006) 

Antifibrotic effects of hepatocyte growth factor on scleroderma fibroblasts and analysis of its mechanism. 

Modern Rheumatology, 16, 364-371. 


Shim,Y.M., Zhu,Z., Zheng,T., Lee,C.G., Homer,R.J., Ma,B. and Elias,J.A. (2006) Role of 5-Lipoxygenase in IL-13- 

Induced Pulmonary Inflammation and Remodeling. The Journal of Immunology, 177, 1918. 

Porcine Heart Valves 

Stock,U.A., Degenkolbe,I., Attmann,T., Schenke-Layland,K., Freitag,S. and Lutter,G. (2006) Prevention of devicerelated 

tissue damage during percutaneous deployment of tissue-engineered heart valves. The Journal of 

Thoracic and Cardiovascular Surgery, 131, 1323-1330. 

Murine Lung Tissue and Bronchoalveolar Lavage Fluid 

Sun,C.X., Zhong,H., Mohsenin,A., Morschl,E., Chunn,J.L., Molina,J.G., Belardinelli,L., Zeng,D. and Blackburn,M.R. 

(2006) Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. 

Journal of Clinical Investigation, 116, 2173-2182. 

Human Tendon Fibroblasts 

Talwalkar,S.C., Evans,C.E., Trail,I.A. and McGrouther,D.A. (2006) Does Anatomical Location of a Tendon (Hand or 

Forearm) Influences Fibroblast Function in the Presence of Physical Forces. Journal of Bone and Joint Surgery – 

British Volume 88-B Supp. III:411.


Volmer,J.B., Thompson,L.F. and Blackburn,M.R. (2006) Ecto-5'-Nucleotidase (CD73)-Mediated Adenosine Production Is 

Tissue Protective in a Model of Bleomycin-Induced Lung Injury. The Journal of Immunology, 176, 4449-4458. 


Wang,C.H., Lee,T.H., Lu,C.N., Chou,W.Y., Hung,K.S., Concejero,A.M. and Jawan,B. (2006) Electroporative alpha-MSH 

gene transfer attenuates thioacetamide-induced murine hepatic fibrosis by MMP and TIMP modulation. Gene 

Therapy, 13, 1000-1009. 

Bovine Annulus Fibrosus Primary Cell Culture 

Wilda,H. and Gough,J.E. (2006) In vitro studies of annulus fibrosus disc cell attachment, differentiation and matrix 

production on PDLLA/45S5 Bioglass composite films. Biomaterials, 27, 5220-5229. 


Wu,G.L.D.M. and Varga,J. (2006) Increased Bleomycin-Induced Skin Fibrosis in Mice Lacking the Th1-Specific 

Transcription Factor T-bet. Pathobiology, 73, 224-237. 


Yasuoka,H., Jukic,D.M., Zhou,Z., Choi,A.M. and Feghali-Bostwick,C.A. (2006) Insulin-like growth factor binding protein 

5 induces skin fibrosis: A novel murine model for dermal fibrosis. Arthritis Rheum, 54, 3001-3010. 

2005 

Murine Lung Explant 

Aono,Y., Nishioka,Y., Inayama,M., Ugai,M., Kishi,J., Uehara,H., Izumi,K. and Sone,S. (2005) Imatinib as a Novel 

Antifibrotic Agent in Bleomycin-induced Pulmonary Fibrosis in Mice. American Journal of Respiratory and 

Critical Care Medicine, 171, 1279. 

Murine Lung Explants 

Azuma,A., Li,Y.J., Abe,S., Usuki,J., Matsuda,K., Henmi,S., Miyauchi,Y., Ueda,K., Izawa,A. and Sone,S. (2005) 

Interferon-β Inhibits Bleomycin-Induced Lung Fibrosis by Decreasing Transforming Growth Factor-β and 

Thrombospondin. American Journal of Respiratory Cell and Molecular Biology, 32, 93-98. 


Barbarin,V., Xing,Z., Delos,M., Lison,D. and Huaux,F. (2005) Pulmonary overexpression of IL-10 augments lung fibrosis 

and Th2 responses induced by silica particles. American Journal of Physiology- Lung Cellular and Molecular 

Physiology, 288, 841-848. 


Beamer,C.A. and Holian,A. (2005) Scavenger receptor class A type I/II (CD204) null mice fail to develop fibrosis 

following silica exposure. American Journal of Physiology- Lung Cellular and Molecular Physiology, 289, 186- 

195. 


Burdick,M.D., Murray,L.A., Keane,M.P., Xue,Y.Y., Zisman,D.A., Belperio,J.A. and Strieter,R.M. (2005) CXCL11 

Attenuates Bleomycin-induced Pulmonary Fibrosis via Inhibition of Vascular Remodeling. American Journal of 

Respiratory and Critical Care Medicine, 171, 261.


Cabral,W.A., Makareeva,E., Colige,A., Letocha,A.D., Ty,J.M., Yeowell,H.N., Pals,G., Leikin,S. and Marini,J.C. (2005) 

Mutations Near Amino End of alpha 1(I) Collagen Cause Combined Osteogenesis Imperfecta/Ehlers-Danlos 

Syndrome by Interference with N-propeptide Processing. Journal of Biological Chemistry, 280, 19259-19269. 

Human to Mouse Cardiac Allografts 

Campbell,L.G., Ramachandran,S., Liu,W., Shipley,J.M., Itohara,S., Rogers,J.G., Moazami,N., Senior,R.M. and 

Jaramillo,A. (2005) Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the 

pathogenesis of cardiac allograft rejection. Am J Transplant, 5, 517-528. 

Human Dental Pulp Cells 

Chan,C.P., Lan,W.H., Chang,M.C., Chen,Y.J., Lan,W.C., Chang,H.H. and Jeng,J.H. (2005) Effects of TGF-βs on the 

growth, collagen synthesis and collagen lattice contraction of human dental pulp fibroblasts in vitro. Archives 

of Oral Biology, 50, 469-479. 


Chen,Q., Rabach,L., Noble,P., Zheng,T., Lee,C.G., Homer,R.J. and Elias,J.A. (2005) IL-11 Receptor a in the 

Pathogenesis of IL-13-Induced Inflammation and Remodeling 1. The Journal of Immunology, 174, 2305-2313. 

Human Periodontal Fibroblasts 

Chen,Y.J., Jeng,J.H., Jane Yao,C.C., Chen,M.H., Hou,L.T. and Lan,W.H. (2005) Long-term effect of pulsed Nd: YAG 

laser irradiation on cultured human periodontal fibroblasts. Lasers in Surgery and Medicine, 36, 225-233. 


Choi,E.M. (2005) The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells. 

Biochem Pharmacol, 70, 363-368. 


Chunn,J.L., Molina,J.G., Mi,T., Xia,Y., Kellems,R.E. and Blackburn,M.R. (2005) Adenosine-Dependent Pulmonary 

Fibrosis in Adenosine Deaminase-Deficient Mice 1. The Journal of Immunology, 175, 1937-1946. 


Comporti,M., Arezzini,B., Signorini,C., Sgherri,C., Monaco,B. and Gardi,C. (2005) F2-isoprostanes stimulate collagen 

synthesis in activated hepatic stellate cells: a link with liver fibrosis?’ Laboratory Investigation, 85, 1381-1391. 

Equine Tendons 

Dahlgren,L., Mohammed,H. and Nixon,A. (2005) Temporal expression of growth factors and matrix molecules in healing 

tendon lesions. Journal of Orthopaedic Research, 23, 84-92. 

Murine Thrombi 

Deatrick,K.B., Eliason,J.L., Lynch,E.M., Moore,A.J., Dewyer,N.A., Varma,M.R., Pearce,C.G., Upchurch,G.R., 

Wakefield,T.W. and Henke,P.K. (2005) Vein wall remodeling after deep vein thrombosis involves matrix 

metalloproteinases and late fibrosis in a mouse model. J Vasc Surg, 42, 140-148. 

Murine Abdominal Wall Samples 

DuBay,D.A., Wang,X., Adamson,B., Kuzon,W.M., Dennis,R.G. and FRANZ,M.G. (2005) Progressive fascial wound failure 

impairs subsequent abdominal wall repairs: A new animal model of incisional hernia formation. Surgery, 137, 

463-471.

Simian Renal Fibroblasts (NRK-49F) 

El Chaar,M., Attia,E., Chen,J., Hannafin,J., Poppas,D.P. and Felsen,D. (2005) Cyclooxygenase-2 Inhibitor Decreases 

Extracellular Matrix Synthesis in Stretched Renal Fibroblasts. Nephron Exp Nephrol, 100, 150-155. 

Ovine Vascular Smooth Muscle Cells 

Engelmayr,G.C., Mayer,J.E., Rabkin,E., Sacks,M.S., Schoen,F.J. and Sutherland,F.W.H. (2005) The independent role of 

cyclic flexure in the early in vitro development of an engineered heart valve tissue. Biomaterials, 26, 175-187. 

Murine Colon Homogenate 

Fichtner-Feigl,S., Fuss,I.J., Preiss,J.C., Strober,W. and Kitani,A. (2005) Treatment of murine Th1-and Th2-mediated 

inflammatory bowel disease with NF-κB decoy oligonucleotides. Journal of Clinical Investigation, 115, 3057- 

3071. 

Ovine Mesenchymal Progenitor Cells and Fetal Chondrocytes 

Fuchs, J. R., Hannouche, D., Terada, S., Zand, S., Vacanti, J. P., and Fauza, D. O. (2005) Cartilage Engineering from 

Ovine Umbilical Cord Blood Mesenchymal Progenitor Cells. Stem Cells 23, 958-964. 

Murine Fibroblasts and Mesenchymal Stem Cells 

Ge,Z., Goh,J.C.H. and Lee,E.H. (2005) Selection of Cell Source for Ligament Tissue Engineering. Cell Transplantation, 

14, 573-583. 

Murine Lung Biopsies 

Genovese,T., Cuzzocrea,S., Di Paola,R., Failla,M., Mazzon,E., Sortino,M.A., Frasca,G., Gili,E., Crimi,N. and Caputi,A.P. 

(2005) Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung 

injury. Respir Res, 6, 58. 

Porcine Anterior Cruciate Ligaments 

Harrison,R.D. (2005) Effect of Extraction Protocols and Epidermal Growth Factor on the Cellular Repopulaton of 

Decellularized Anterior Cruciate Ligament Allografts. Biomed Mater Res A,75, 841-854. 

Murine Hepatic Stellate cells (HSC-T6) and Liver Samples 

Hsu,Y.C., Lin,Y.L., Chiu,Y.T., Shiao,M.S., Lee,C.Y. and Huang,Y.T. (2005) Antifibrotic effects of Salvia miltiorrhiza on 

dimethylnitrosamine-intoxicated rats. Journal of Biomedical Science, 12, 185-195. 

Rat Left Ventricle 

Iwata,K., Sawa,Y., Kitagawa-Sakakida,S., Kawaguchi,N., Matsuura,N., Nakamura,T. and Matsuda,H. (2005) Gene 

transfection of hepatocyte growth factor attenuates the progression of cardiac remodeling in the 

hypertrophied heart. The Journal of Thoracic and Cardiovascular Surgery, 130, 719-725. 


Kato,T., Okahashi,N., Kawai,S., Kato,T., Inaba,H., Morisaki,I. and Amano,A. (2005) Impaired Degradation of Matrix 

Collagen in Human Gingival Fibroblasts by the Antiepileptic Drug Phenytoin. J Periodontol, 76, 941-950. 

Human Periodontal Ligament Cell Cultures 

Kawase,T., Okuda,K., Saito,Y. and Yoshie,H. (2005) In vitro evidence that the biological effects of platelet-rich plasma 

on periodontal ligament cells is not mediated solely by constituent transforming-growth factor-beta or 

platelet-derived growth factor. J Periodontol, 76, 760-767.

Cadaveric Human Lumbar Intervertebral Discs 

Keshari,K.R., Lotz,J.C., Kurhanewicz,J. and Majumdar,S. (2005) Correlation of HR-MAS Spectroscopy Derived 

Metabolite Concentrations With Collagen and Proteoglycan Levels and Thompson Grade in the Degenerative 

Disc. Spine, 30, 2683-2688. 

Human Myocardial Samples 

Klotz, S., Foronjy, R. F., Dickstein, M. L., Gu, A., Garrelds, I. M., Jan Danser, A. H., Oz, M. C., D'Armiento, J., and 

Burkhoff, D. (2005) Mechanical Unloading During Left Ventricular Assist Device Support Increases Left 

Ventricular Collagen Cross-Linking and Myocardial Stiffness. Circulation 112, 364-374. 

Porcine Aortic Valves in Culture 

Konduri,S., Xing,Y., Warnock,J.N., He,Z. and Yoganathan,A.P. (2005) Normal Physiological Conditions Maintain the 

Biological Characteristics of Porcine Aortic Heart Valves: An Ex Vivo Organ Culture Study. Annals of Biomedical 

Engineering, 33, 1158-1166. 

Murine Kidney Cortex 

Kushibiki,T., Nagata-Nakajima,N., Sugai,M., Shimizu,A. and Tabata,Y. (2005) Delivery of plasmid DNA expressing small 

interference RNA for TGF-beta type II receptor by cationized gelatin to prevent interstitial renal fibrosis. J 

Control Release, 105, 318-331. 

Murine Dermal Fibroblasts 

Lateef,H., Aslam,M.N., Stevens,M.J. and Varani,J. (2005) Pretreatment of diabetic rats with lipoic acid improves 

healing of subsequently-induced abrasion wounds. Archives of Dermatological Research, 297, 75-83. 

Murine Granulomas 

Layland,L.E., Wagner,H. and Prazeres da Costa,C. (2005) Lack of antigen-specific Th1 response alters granuloma 

formation and composition in Schistosoma mansoni-infected MyD88-/-mice. Eur.J.Immunol, 35, 3248-3257. 

Human Ligament Fibroblasts 

Lee,C.H., Shin,H.J., Cho,I.H., Kang,Y.M., Kim,I.A., Park,K.D. and Shin,J.W. (2005) Nanofiber alignment and direction 

of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials, 26, 1261-1270. 


Lee,K.H. and Choi,E.M. (2005) Biochanin A Stimulates Osteoblastic Differentiation and Inhibits Hydrogen Peroxide- 

Induced Production of Inflammatory Mediators in MC3T3-E1 Cells. Biological & Pharmaceutical Bulletin, 28, 

1948-1953. 

Murine Lung Tissue Supernatant 

Liu,H., Drew,P., Gaugler,A.C., Cheng,Y. and Visner,G.A. (2005) Pirfenidone inhibits lung allograft fibrosis through Larginine-arginase 

pathway. Am J Transplant, 5, 1256-1263. 


Matsushita,M., Yamamoto,T. and Nishioka,K. (2005) Plasminogen activator inhibitor-1 is elevated, but not essential, in 

the development of bleomycin-induced murine scleroderma. Clinical and Experimental Immunology, 139, 429- 

438. 

Human Venous Myofibroblasts 

Mol,A., van Lieshout,M.I., Dam-de Veen,C.G., Neuenschwander,S., Hoerstrup,S.P., Baaijens,F.P. and Bouten,C.V.C. 

(2005) Fibrin as a cell carrier in cardiovascular tissue engineering applications. Biomaterials, 26, 3113-3121.


Moore,B.B., Ballinger,M.N., White,E.S., Green,M.E., Herrygers,A.B., Wilke,C.A., Toews,G.B. and Peters-Golden,M. 

(2005) Bleomycin-Induced E Prostanoid Receptor Changes Alter Fibroblast Responses to Prostaglandin E2 1. The 

Journal of Immunology, 174, 5644-5649. 

Cricetine Left Ventricles 

Nakamura,T., Matsumoto,K., Mizuno,S., Sawa,Y., Matsuda,H. and Nakamura,T. (2005) Hepatocyte growth factor 

prevents tissue fibrosis, remodeling, and dysfunction in cardiomyopathic hamster hearts. American Journal of 

Physiology- Heart and Circulatory Physiology, 288, 2131-2139. 

Human Lung Fibroblast Culture Supernatants 

Nakoman,C., Resmi,H., Ay,O., Acikel,U., Atabey,N. and Güner,G. (2005) Effects of basic fibroblast factor (bFGF) on 

MMP-2, TIMP-2, and type-I collagen levels in human lung carcinoma fibroblasts. Biochimie, 87, 343-351. 

Leporine Temporomandibular Joint Discs 

Naqvi,T., Duong,T.T., Hashem,G., Shiga,M., Zhang,Q. and Kapila,S. (2005) Relaxin's induction of metalloproteinases is 

associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants. 

Arthritis Res Ther, 7, R1-11. 


Nethery,D.E., Moore,B.B., Minowada,G., Carroll,J., Faress,J.A. and Kern,J.A. (2005) Expression of mutant human 

epidermal receptor 3 attenuates lung fibrosis and improves survival in mice. Journal of Applied Physiology, 99, 

298-307. 

Human Atheromatous Plaques 

Penz, S., Reininger, A. J., Brandl, R., Goyal, P., Rabie, T., Bernlochner, I., Rother, E., Goetz, C., Engelmann, B., and 

Smethurst, P. A. (2005) Human atheromatous plaques stimulate thrombus formation by activating platelet 

glycoprotein VI. The FASEB Journal 19, 898-909. 2005. 

Porcine Chordae Tendineae 

Ritchie, J., Warnock, J. N., and Yoganathan, A. P. (2005) Structural Characterization of the Chordae Tendineae in 

Native Porcine Mitral Valves. The Annals of Thoracic Surgery 80, 189-197. 

Murine Osteoblast Primary Cultures 

Sampaio,B.V., Göller,G., Oktar,F.N., Val rio,P., Goes,A.M. and Leite,M.F. (2005) Biocompatibility Evaluation of Three 

Different Titanium-Hydroxyapatite Composites. Key Eng.Mater, 284, 639-642. 


Santiago,B., Gutierrez-Cañas,I., Dotor,J., Palao,G., Lasarte,J.J., Ruiz,J., Prieto,J., Borrbs-Cuesta,F., Pablos,J.L. and 

Biotech,D. (2005) Topical Application of a Peptide Inhibitor of Transforming Growth Factor-bold beta 1 

Ameliorates Bleomycin-Induced Skin Fibrosis. Journal of Investigative Dermatology, 125, 450-455. 

Murine Osteoblast Primary Cultures 

Schainberg,APM., Özyeğin,LS., Kursuoğlu,P., Valério,P., Goes,AM. and Leite,MF. (2005) Biocompatibility evaluation of 

Zeolite compared to bone HA, calcium phosphate (Ca2PO4) and Eugenol Paste. Key Engineering Materials 284- 

286, 561-564. 


Strieter,R.M., Keane,M.P., Burdick,M.D., Sakkour,A., Murray,L.A. and Belperio,J.A. (2005) The role of CXCR2/CXCR2 

ligands in acute lung injury. Curr.Drug Targets Inflamm.Allergy, 4, 299-303.

Human Hepatic Stellate LI90 Cell Line 

Sugimoto,R., Enjoji,M., Nakamuta,M., Ohta,S., Kohjima,M., Fukushima,M., Kuniyoshi,M., Arimura,E., Morizono,S. and 

Kotoh,K. (2005) Effect of IL-4 and IL-13 on collagen production in cultured LI90 human hepatic stellate cells. 

Liver International, 25, 420-428. 

Ovine Fetal and Adult Chondrocytes 

Terada,S., Fuchs,J.R., Yoshimoto,H., Fauza,D.O. and Vacanti,J.P. (2005) In Vitro Cartilage Regeneration From 

Proliferated Adult Elastic Chondrocytes. Annals of Plastic Surgery, 55, 196-201. 

Ovine Chondrocytes 

Terada,S., Yoshimoto,H., Fuchs,J.R., Sato,M., Pomerantseva,I., Selig,M.K., Hannouche,D. and Vacanti,J.P. (2005) 

Hydrogel optimization for cultured elastic chondrocytes seeded onto a polyglycolic acid scaffold. 

J.Biomed.Mater.Res.75A, 907-916. 

Murine Osteoblast Primary Culture 

Valério,P., Guimarbes,M.H.R., Pereira,M.M., Leite,M.F. and Goes,A.M. (2005) Primary osteoblast cell response to solgel 

derived bioactive glass foams. Journal of Materials Science: Materials in Medicine, 16, 851-856. 

Human Fibroblast Primary Culture 

Vancheri,C., Gili,E., Failla,M., Mastruzzo,C., Salinaro,E.T., LoFurno,D., Pistorio,M.P., La Rosa,C., Caruso,M. and 

Crimi,N. (2005) Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2 

receptor. The Journal of Allergy and Clinical Immunology, 116, 1242-1248. 


Vittal, R., Horowitz, J. C., Moore, B. B., Zhang, H., Martinez, F. J., Toews, G. B., Standiford, T. J., and Thannickal, V. 

J. (2005) Modulation of Prosurvival Signaling in Fibroblasts by a Protein Kinase Inhibitor Protects against 

Fibrotic Tissue Injury. American Journal of Pathology 166, 367-375. 

Canine Arterial Tissue 

Yamaguchi-Okada,M., Nishizawa,S., Koide,M. and Nonaka,Y. (2005) Biomechanical and phenotypic changes in the 

vasospastic canine basilar artery after subarachnoid hemorrhage. Journal of Applied Physiology, 99, 2045- 

2052. 

Murine Pancreatic Tissue 

Yoo,B.M., Yeo,M., Oh,T.Y., Choi,J.H., Kim,W.W., Kim,J.H., Cho,S.W., Kim,S.J. and Hahm,K.B. (2005) Amelioration of 

pancreatic fibrosis in mice with defective TGF-beta signaling. Pancreas, 30, e71-e79. 

Murine Pancreatic Tissue 

Yoo,B.M., Oh,T.Y., Kim,Y.B., Yeo,M., Lee,J.S., Surh,Y.J., Ahn,B.O., Kim,W.H., Sohn,S. and Kim,J.H. (2005) Novel 

Antioxidant Ameliorates the Fibrosis and Inflammation of Cerulein-Induced Chronic Pancreatitis in a Mouse 

Model. Pancreatology, 5, 165-176. 


Zhou,Y-j., Yin,D-m., Chen,H-s., Shi,J-h., Sha,B-x. and Wang,X. (2005) Inhibitory effects of idoxifene on hepatic fibrosis 

in rats. Acta Pharmacologia Sinica, 26, 581-586.

2004 


Barbarin, V., Arras, M., Misson, P., Delos, M., McGarry, B., Phan, S. H., Lison, D., and Huaux, F. (2004) 

Characterization of the Effect of Interleukin-10 on Silica-Induced Lung Fibrosis in Mice. American Journal of 

Respiratory Cell and Molecular Biology 31, 78-85. 299. 


Belperio,J.A., Dy,M., Murray,L., Burdick,M.D., Xue,Y.Y., Strieter,R.M. and Keane,M.P. (2004) The Role of the Th2 CC 

Chemokine Ligand CCL17 in Pulmonary Fibrosis 1. The Journal of Immunology, 173, 4692-4698. 

Human Lung Tissue Samples and Murine Lung Homogenates 

Berman,J.S., Serlin,D., Li,X., Whitley,G., Hayes,J., Rishikof,D.C., Ricupero,D.A., Liaw,L., Goetschkes,M. and 

O'Regan,A.W. (2004) Altered bleomycin-induced lung fibrosis in osteopontin-deficient mice. American Journal 

of Physiology- Lung Cellular and Molecular Physiology, 286, 1311-1318. 

Murine Mammary Carcinoma MCa Cell Line 

Casarsa,C., Mischis,M.T. and Sava,G. (2004) TGFbeta1 regulation and collagen-release-independent connective tissue 

re-modelling by the ruthenium complex NAMI-A in solid tumours. Journal of Inorganic Biochemistry, 98, 1648- 

1654. 


Cho,J. (2004) ISS inhibits expression of MMP-9 and MMP-2 in a mouse model of airway remodeling. The Journal of 

Allergy and Clinical Immunology, 113, 92. 

Human Patellar Tendon Fibroblasts 

Cilli,F., Khan,M., Fu,F. and Wang,J.H. (2004) Prostaglandin E2 affects proliferation and collagen synthesis by human 

patellar tendon fibroblasts. Clin J Sport Med, 14, 232-236. 

Human Pediatric Aortic Cells 

Fu,P., Sodian,R., Luders,C., Lemke,T., Kraemer,L., Hubler,M., Weng,Y., Hoerstrup,S.P., Meyer,R. and Hetzer,R. (2004) 

Effects of basic fibroblast growth factor and transforming growth factor-beta on maturation of human pediatric 

aortic cell culture for tissue engineering of cardiovascular structures. ASAIO J, 50, 9-14. 


Hattori, N., Mizuno, S., Yoshida, Y., Chin, K., Mishima, M., Sisson, T. H., Simon, R. H., Nakamura, T., and Miyake, M. 

(2004) The Plasminogen Activation System Reduces Fibrosis in the Lung by a Hepatocyte Growth Factor- 

Dependent Mechanism. American Journal of Pathology, 164, 1091-1098. 


Honda,K., Marquillies,P., Capron,M. and Dombrowicz,D. (2004) Peroxisome proliferator-activated receptor γ is 

expressed in airways and inhibits features of airway remodeling in a mouse asthma model. The Journal of 

Allergy and Clinical Immunology, 113, 882-888. 

Murine Liver Tissues 

Hsu,Y.C., Chiu,Y.T., Lee,C.Y., Lin,Y.L. and Huang,Y.T. (2004) Increases in fibrosis-related gene transcripts in livers of 

dimethylnitrosamine-intoxicated rats. Journal of Biomedical Science, 11, 408-417.

Murine Periodontal Ligament Cells 

Inoue,M., LeGeros,R.Z., Hoffman,C., Diamond,K., Rosenberg,P.A. and Craig,R.G. (2004) Effect of enamel matrix 

proteins on the phenotype expression of periodontal ligament cells cultured on dental materials. Journal of 

Biomedical Materials Research, 69, 172-179. 

Murine Osteoblast-like (MC3T3-E1) and Odontoblast-like (MDPC23) Cell Lines 

Inoue,M., LeGeros,R.Z., Inoue,M., Tsujigiwa,H., Nagatsuka,H., Yamamoto,T. and Nagai,N. (2004) In vitro response of 

osteoblast-like and odontoblast-like cells to unsubstituted and substituted apatites. Journal of Biomedical 

Materials Research, 70, 585-593. 


Kolodsick,J.E., Toews,G.B., Jakubzick,C., Hogaboam,C., Moore,T.A., McKenzie,A., Wilke,C.A., Chrisman,C.J. and 

Moore,B.B. (2004) Protection from Fluorescein Isothiocyanate-Induced Fibrosis in IL-13-Deficient, but Not IL-4- 

Deficient, Mice Results from Impaired Collagen Synthesis by Fibroblasts 1. The Journal of Immunology, 172, 

4068-4076. 

Murine Hepatic Stellate Cells and Liver Tissue and Human Hepatic Stellate (TWNT-4) Cell Line 

Kotoh,K., Nakamuta,M., Kohjima,M., Fukushima,M., Morizono,S., Kobayashi,N., Enjoji,M. and Nawata,H. (2004) Arg- 

Gly-Asp (RGD) peptide ameliorates carbon tetrachloride-induced liver fibrosis via inhibition of collagen 

production and acceleration of collagenase activity. Int J Mol Med, 14, 1049-1053. 

Human Fibroblast (NHDF) Cell Line 

Koya-Miyata,S., Okamoto,I., Ushio,S., Iwaki,K., Ikeda,M. and Kurimoto,M. (2004) Identification of a Collagen 

Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism. Bioscience, 

Biotechnology, and Biochemistry, 68, 767-773. 

Human Dermal Biopsy 

Lateef, H., Stevens, M. J., and Varani, J. (2004) All-trans-Retinoic Acid Suppresses Matrix Metalloproteinase Activity 

and Increases Collagen Synthesis in Diabetic Human Skin in Organ Culture. American Journal of Pathology 165, 

167-174. 

Human and Murine Bone Marrow Stromal Fibroblasts 

Lawson,M.A., Barralet,J.E., Wang,L., Shelton,R.M. and Triffitt,J.T. (2004) Adhesion and Growth of Bone Marrow 

Stromal Cells on Modified Alginate Hydrogels. Tissue Engineering, 10, 1480-1491. 


Lee,C.G., Link,H., Baluk,P., Homer,R.J., Chapoval,S., Bhandari,V., Kang,M.J., Cohn,L., Kim,Y.K. and McDonald,D.M. 

(2004) Vascular endothelial growth factor (VEGF) induces remodeling and enhances T H 2-mediated 

sensitization and inflammation in the lung. Nature Medicine, 10, 1095-1103. 

Leporine Chondrocytes 

Lee,J. and Son,Y. (2004) TGF-beta Stimulates Conversion of Fibrocartilage Phenotype of Costal Chondrocytes. Tissue 

Eng.Reg.Med, 1, 171-177. 

Human Embryonic Kidney (HEK-293, 293-EBNA and 293-T) Cell Lines and Human Fibrosarcoma (HT-1080) 

Cell Line 

Leitinger,B., Steplewski,A. and Fertala,A. (2004) The D2 period of collagen II contains a specific binding site for the 

human discoidin domain receptor, DDR2. J Mol Biol, 344, 993-1003.

Human Cardiac Left Ventricle Tissue 

Liang,H., Müller,J., Weng,Y.G., Wallukat,G., Fu,P., Lin,HS, Bartel,S., Knosalla,C., Pregla,R. and 

Hetzer,R.(2004) Changes in myocardial collagen content before and after left ventricular assist device 

application in dilated cardiomyopathy. Chinese Medical Journal, 117, 401-407. 


Mcmillan,S.J. and Lloyd,C.M. (2004) Prolonged allergen challenge in mice leads to persistent airway remodelling. 

Clinical & Experimental Allergy, 34, 497-507. 

Human Colonic Tissue 

Mimura,T., Bateman,A.C., Lee,R.L., Johnson,P.A., McDonald,P.J., Talbot,I.C., Kamm,M.A., MacDonald,T.T. and 

Pender,S.L.F. (2004) Up-Regulation of Collagen and Tissue Inhibitors of Matrix Metalloproteinase in Colonic 

Diverticular Disease. Diseases of the Colon & Rectum, 47, 371-379. 


Nomura,Y., Taniguchi,M., Miyata,M., Ariyasu,T., Yamauchi,H., Ikeda,M. and Kurimoto,M. (2004) Interferon-gamma 

liniment protects hairless mice against ultraviolet irradiation-induced skin damage. Biomedical Research, 25, 

277-285. 


Ono, M., Sawa, Y., Mizuno, S., Fukushima, N., Ichikawa, H., Bessho, K., Nakamura, T., and Matsuda, H. (2004) 

Hepatocyte Growth Factor Suppresses Vascular Medial Hyperplasia and Matrix Accumulation in Advanced 

Pulmonary Hypertension of Rats. Circulation, 110, 2896-2902. 

Murine Gingival Fibroblasts 

Paik,J.W., Kim,C.S., Cho,K.S., Chai,J.K., Kim,C.K. and Choi,S.H. (2004) Inhibition of cyclosporin A-induced gingival 

overgrowth by azithromycin through phagocytosis: an in vivo and in vitro study. J Periodontol, 75, 380-387. 


Phillips,R.J., Burdick,M.D., Hong,K., Lutz,M.A., Murray,L.A., Xue,Y.Y., Belperio,J.A., Keane,M.P. and Strieter,R.M. 

(2004) Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. Journal of Clinical 

Investigation, 114, 438-446. 

Leporine Bronchoalveolar Lavage Fluid 

Schmidt,R., Ruppert,C., Markart,P., Lubke,N., Ermert,L., Weissmann,N., Breithecker,A., Ermert,M., Seeger,W. and 

Gunther,A. (2004) Changes in pulmonary surfactant function and composition in bleomycin-induced 

pneumonitis and fibrosis. Toxicology and Applied Pharmacology, 195, 218-231. 

Ovine, Leporine and Murine Tissue Constructs 

Shieh,S.J. and Terada,S. (2004) Tissue engineering auricular reconstruction: in vitro and in vivo studies. Biomaterials, 

25, 1545-1557. 

Bovine Collagen 

Skilbeck,C.A., Walker,P.G., David,T. and Nash,G.B. (2004) Disturbed flow promotes deposition of leucocytes from 

flowing whole blood in a model of a damaged vessel wall. British Journal of Haematology, 126, 418-427. 

Human Fibrosarcoma (HT-1080) Cell Line Procollagen 

Steplewski,A., Ito,H., Rucker,E., Brittingham,R.J., Alabyeva,T., Gandhi,M., Ko,F.K., Birk,D.E., Jimenez,S.A. and 

Fertala,A. (2004) Position of single amino acid substitutions in the collagen triple helix determines their effect 

on structure of collagen fibrils. J Struct Biol, 148, 326-337.


Sue,R.D., Belperio,J.A., Burdick,M.D., Murray,L.A., Xue,Y.Y., Dy,M.C., Kwon,J.J., Keane,M.P. and Strieter,R.M. (2004) 

CXCR2 Is Critical to Hyperoxia-Induced Lung Injury 1. The Journal of Immunology, 172, 3860-3868. 

Human Lymphoblast-like Jurkat D1.1 and E6-1 Cell Lines and Human Primary Fibroblast Lines 

Suppl,A., Yurovsky,V.V. and White,B. (2004) Effect of CD154-CD40 interactions on collagen production by fibroblasts. 

Arthritis Res. 3A, P062. 


Suzuki,M., Tanabe,F., Nakamura,S., Motoda,R. and Orita,K. (2004) NK-355, an aminovinyl photosensitizing dye, 

enhances collagen production through TGF-β1 upregulation. Journal of Dermatological Science, 34, 56-58. 

Murine Brain Tissue 

Tang,J., Liu,J., Zhou,C., Alexander,J.S., Nanda,A., Granger,D.N. and Zhang,J.H. (2004) MMP-9 Deficiency Enhances 

Collagenase-Induced Intracerebral Hemorrhage and Brain Injury in Mutant Mice. Journal of Cerebral Blood Flow 

& Metabolism, 24, 1133-1145. 


Valerio,P., Pereira,M.M., Goes,A.M. and Leite,M.F. (2004) The effect of ionic products from bioactive glass dissolution 

on osteoblast proliferation and collagen production. Biomaterials, 25, 2941-2948. 


Varma,M.R., Moaveni,D.M., Dewyer,N.A., Varga,A.J., Deatrick,K.B., Kunkel,S.L., Upchurch Jr,G.R., Wakefield,T.W. 

and Henke,P.K. (2004) Deep vein thrombosis resolution is not accelerated with increased neovascularization. J 

Vasc Surg, 40, 536-542. 

Murine Primary Hepatic Stellate Cell Line 

Wada,W., Kuwano,H., Hasegawa,Y. and Kojima,I. (2004) The Dependence of Transforming Growth Factor-β-Induced 

Collagen Production on Autocrine Factor Activin A in Hepatic Stellate Cells. Endocrinology, 145, 2753-2759. 


Watanabe,S., Nagashio,Y., Asaumi,H., Nomiyama,Y., Taguchi,M., Tashiro,M., Kihara,Y., Nakamura,H. and Otsuki,M. 

(2004) Pressure activates rat pancreatic stellate cells. American Journal of Physiology- Gastrointestinal and 

Liver Physiology, 287, 1175-1181. 


Yamamoto,T. and Nishioka,K. (2004) Animal model of sclerotic skin. VI: Evaluation of bleomycin-induced skin sclerosis 

in nude mice. Archives of Dermatological Research, 295, 453-456. 


Yamamoto,T. and Nishioka,K. (2004) Possible Role of Apoptosis in the Pathogenesis of Bleomycin-Induced Scleroderma. 

Journal of Investigative Dermatology, 122, 44-50. 

Human Left Ventricle Tissue Biopsies 

Zhang,J. and Narula,J. (2004) Molecular biology of myocardial recovery. Surg Clin North Am, 84, 223-242.

Human Pulmonary Fibroblasts 

Zhang,L., Keane,M.P., Zhu,L.X., Sharma,S., Rozengurt,E., Strieter,R.M., Dubinett,S.M. and Huang,M. (2004) 

Interleukin-7 and Transforming Growth Factor-{beta} Play Counter-regulatory Roles in Protein Kinase C-{delta}dependent 

Control of Fibroblast Collagen Synthesis in Pulmonary Fibrosis. Journal of Biological Chemistry, 

279, 28315-28319. 

2003 


Blackburn,M.R., Lee,C.G., Young,H.W.J., Zhu,Z., Chunn,J.L., Kang,M.J., Banerjee,S.K. and Elias,J.A. (2003) Adenosine 

mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine 

amplification pathway. Journal of Clinical Investigation, 112, 332-344. 

Trout Plasma, Endolymph and Otolith Explant 

Borelli,G., Guibbolini,M.E., Mayer-Gostan,N., Priouzeau,F., De Pontual,H., Allemand,D., Puverel,S., Tambutte,E. and 

Payan,P. (2003) Daily variations of endolymph composition: relationship with the otolith calcification process in 

trout. Journal of Experimental Biology, 206, 2685-2692. 


Cabral,W.A., Mertts,M.V., Makareeva,E., Colige,A., Tekin,M., Pandya,A., Leikin,S. and Marini,J.C. (2003) Type I 

Collagen Triplet Duplication Mutation in Lethal Osteogenesis Imperfecta Shifts Register of a Chains throughout 

the Helix and Disrupts Incorporation of Mutant Helices into Fibrils and Extracellular Matrix. Journal of 

Biological Chemistry, 278, 10006-10012. 


Chung,MP., Monick,MM., Hamzeh,NY., Butler,NS., Powers,LS. and Hunninghake,GW. (2003) Role of repeated lung injury 

and genetic background in bleomycin-induced fibrosis. American Journal of Respiratory Cell and Molecular 

Biology 29, 375-380. 


Denton,C.P., Zheng,B., Evans,L.A., Shi-wen,X., Ong,V.H., Fisher,I., Lazaridis,K., Abraham,D.J., Black,C.M. and de 

Crombrugghe,B. (2003) Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor 

β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice. 

Journal of Biological Chemistry, 278, 25109-25119. 

Human Atherosclerotic Plaques 

Goncalves, I., Moses, J., Dias, N., Pedro, L. M., Fernandes e Fernandes, Nilsson, J., and Ares, M. P. S. (2003) Changes 

Related to Age and Cerebrovascular Symptoms in the Extracellular Matrix of Human Carotid Plaques. Stroke 34, 

616-622. 


Huaux,F., Liu,T., McGarry,B., Ullenbruch,M., Xing,Z. and Phan,S.H. (2003) Eosinophils and T Lymphocytes Possess 

Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis 1. The Journal of Immunology, 171, 5470-5481. 

Murine Fibroblasts 

Huaux,F., Liu,T., McGarry,B., Ullenbruch,M. and Phan,S.H. (2003) Dual Roles of IL-4 in Lung Injury and Fibrosis 1. The 

Journal of Immunology, 170, 2083-2092.

Murine Lung Hydrolysates 

Hutson,P.R., Crawford,M.E. and Sorkness,R.L. (2003) Liquid chromatographic determination of hydroxyproline in tissue 

samples. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 791, 427- 

430. 

Leporine Chondrocytes 

Ibusuki,S., Fujii,Y., Iwamoto,Y. and Matsuda,T. (2003) Tissue-Engineered Cartilage Using an Injectable and in Situ 

Gelable Thermoresponsive Gelatin: Fabrication and in Vitro Performance. Tissue Engineering, 9, 371-384. 

Murine Osteoblast-like MC3T3-E1 Cell Line 

Luppen,C.A., Smith,E., Spevak,L., Boskey,A.L. and Frenkel,B. (2003) Bone morphogenetic protein-2 restores 

mineralization in glucocorticoid-inhibited MC3T3-E1 osteoblast cultures. J Bone Miner Res, 18,1186-1197. 

Murine Osteoblast-like MC3T3-E1 Subclone Cell Line 

Luppen,C.A., Leclerc,N., Noh,T., Barski,A., Khokhar,A., Boskey,A.L., Smith,E. and Frenkel,B. (2003) Brief Bone 

Morphogenetic Protein 2 Treatment of Glucocorticoid-inhibited MC3T3-E1 Osteoblasts Rescues Commitmentassociated 

Cell Cycle and Mineralization without Alteration of Runx2. Journal of Biological Chemistry, 278, 

44995-45003. 


Ohnishi, N., Miyata, T., Ohnishi, H., Yasuda, H., Tamada, K., Ueda, N., Mashima, H., and Sugano, K. (2003) Activin A is 

an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic 

fibrosis. Gut 52, 1487-1493. 

Porcine, Ovine and Tissue-Engineered Cardiac Valve Leaflets 

Schenke-Layland,K., Opitz,F., Gross,M., Döring,C., Halbhuber,K.J., Schirrmeister,F., Wahlers,T. and Stock,U.A. (2003) 

Complete dynamic repopulation of decellularized heart valves by application of defined physical signals - an in 

vitro study. Cardiovascular Research, 60, 497-509. 


Suzuki, H., Aoshiba, K., Yokohori, N., and Nagai, A. (2003) Epidermal Growth Factor Receptor Tyrosine Kinase 

Inhibition Augments a Murine Model of Pulmonary Fibrosis 1. Cancer Research 63, 5054-5059. 


Thanaporn,P., Myers,D.D., Wrobleski,S.K., Hawley,A.E., Farris,D.M., Wakefield,T.W. and Henke,P.K. (2003) P-selectin 

inhibition decreases post-thrombotic vein wall fibrosis in a rat model. Surgery, 134, 365-371. 


Valério,P., Goes,A.M., Pereira,M.M. and Leite,M.F. (2003) Cytological and biochemical evaluation of osteoblast in 

contact with ionic products of bioactive ceramics. Key Engineering Materials, 240, 703-706. 

Murine Plasma 

Vergnes,L., Phan,J., Strauss,M., Tafuri,S. and Reue,K. (2003) Cholesterol and Cholate Components of an Atherogenic 

Diet Induce Distinct Stages of Hepatic Inflammatory Gene Expression. Journal of Biological Chemistry, 278, 

42774-42784. 


Yamamoto,T. and Nishioka,K. (2003) Role of Monocyte Chemoattractant Protein-1 and its Receptor, CCR-2, in the 

Pathogenesis of Bleomycin-Induced Scleroderma. Journal of Investigative Dermatology, 121, 510-516.

Human Lung Fibroblast (8F1024, 8F1608 and 9F0892) Cell Lines 

Yurovsky,VV. (2003) Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Enhances Collagen Production by Human 

Lung Fibroblasts. American Journal of Respiratory Cell and Molecular Biology, 28, 225-231. 

2002 


Blease, K., Schuh, J. M., Jakubzick, C., Lukacs, N. W., Kunkel, S. L., Joshi, B. H., Puri, R. K., Kaplan, M. H., and 

Hogaboam, C. M. (2002) Stat6-Deficient Mice Develop Airway Hyperresponsiveness and Peribronchial Fibrosis 

during Chronic Fungal Asthma. American Journal of Pathology 160(2), 481-490. 

Human Pulmonary Fibrosis Fibroblasts, Normal Fibroblasts, U4A, U3A, and U4A/JAK1 Cell Lines and Murine 

Lung Samples 

Huang,M., Sharma,S., Zhu,L.X., Keane,M.P., Luo,J., Zhang,L., Burdick,M.D., Lin,Y.Q., Dohadwala,M. and Gardner,B. 

(2002) IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis. Journal of Clinical 

Investigation, 109, 931-937. 


Jain,V.V., Kitagaki,K., Businga,T., Hussain,I., George,C., O'Shaughnessy,P. and Kline,J.N. (2002) CpGoligodeoxynucleotides 

inhibit airway remodeling in a murine model of chronic asthma. The Journal of Allergy 

and Clinical Immunology, 110, 867-872. 

Murine Liver Samples 

Kitamura,K., Nakamoto,Y., Akiyama,M., Fujii,C., Kondo,T., Kobayashi,K., Kaneko,S. and Mukaida,N. (2002) Pathogenic 

Roles of Tumor Necrosis Factor Receptor p55-Mediated Signals in Dimethylnitrosamine-Induced Murine Liver 

Fibrosis. Lab Invest, 82, 571-584. 

Cultured Neonatal Heart Smooth-Muscle Cells 

Langford,S.D., Trent,M.B. and Boor,P.J. (2002) Semicarbazide-sensitive amine oxidase and extracellular matrix 

deposition by smooth-muscle cells. Cardiovascular Toxicology, 2, 141-150. 


Lanone,S., Zheng,T., Zhu,Z., Liu,W., Lee,C.G., Ma,B., Chen,Q., Homer,R.J., Wang,J. and Rabach,L.A. (2002) 

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and-12 in IL-13-induced 

inflammation and remodeling. Journal of Clinical Investigation, 110, 463-474. 

Murine Cardiac Samples 

Li,Y.Y., Kadokami,T., Wang,P., McTiernan,C.F. and Feldman,A.M. (2002) MMP inhibition modulates TNF-a transgenic 

mouse phenotype early in the development of heart failure. American Journal of Physiology- Heart and 

Circulatory Physiology, 282, 983-989. 

Murine Glomerular Mesangial Cells 

Routh,R., McCarthy,K. and Welbourne,T. (2002) Troglitazone inhibits glutamine metabolism in rat mesangial cells. 

American Journal of Physiology- Endocrinology and Metabolism, 282, 231-238. 


Schuh,JM., Power,CA., Proudfoot,AE., Kunkel,SL, Lukacs,NW and Hogaboam,CM. (2002) Airway hyperresponsiveness, 

but not airway remodeling, is attenuated during chronic pulmonary allergic responses to aspergillus in CCR4-/- 

mice. FASEB J. 16, 1313-1315.


Suhara, H., Sawa, Y., Fukushima, N., Kagisaki, K., Yokoyama, C., Tanabe, T., Ohtake, S., and Matsuda, H. (2002) Gene 

transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension 

in rats. The Journal of Thoracic and Cardiovascular Surgery 123, 855-861. 


Takeda,U., Utani,A., Wu,J., Adachi,E., Koseki,H., Taniguchi,M., Matsumoto,T., Ohashi,T., Sato,M. and Shinkai,H. 

(2002) Targeted Disruption of Dermatopontin Causes Abnormal Collagen Fibrillogenesis. Journal of 

Investigative Dermatology, 119, 678-683. 


Yamamoto,T. and Nishioka,K. (2002) Analysis of the effect of halofuginone on bleomycin-induced scleroderma. 

Rheumatology, 41, 594-596. 

2001 

Bovine Chondrocytes 

Amiel,G.E., Yoo,J.J., Kim,B.S. and Atala,A. (2001) Tissue engineered stents created from chondrocytes. J Urol, 165, 

2091-2095. 

Human Granulosa Cells 

Aston,K.E., Stamouli,A., Thomas,E.J., Vyas,S., Iredale,J.P., Arthur,M.J.P. and Richardson,M.C. (2001) Endocrinology 

and paracrinology Effect of gonadotrophin on cell and matrix retention and expression of metalloproteinases 

and their inhibitor in cultured human granulosa cells modelling corpus luteum function. Molecular Human 

Reproduction, 2, 26-30. 


Blease,K., Jakubzick,C., Schuh,J.M., Joshi,B.H., Puri,R.K. and Hogaboam,C.M. (2001) IL-13 Fusion Cytotoxin 

Ameliorates Chronic Fungal-Induced Allergic Airway Disease in Mice 1. The Journal of Immunology, 167, 6583- 

6592. 

Trout and Turbot Endolymph and Otoliths 

Borelli,G., Mayer-Gostan,N., De Pontual,H., Boeuf,G. and Payan,P. (2001) Biochemical Relationships Between 

Endolymph and Otolith Matrix in the Trout (Oncorhynchus mykiss) and Turbot (Psetta maxima). Calcified 

Tissue International, 69, 356-364. 


Bouma,P., Cabral,W.A., Cole,W.G. and Marini,J.C. (2001) COL5A1 Exon 14 Splice Acceptor Mutation Causes a 

Functional Null Allele, Haploinsufficiency of a1 (V) and Abnormal Heterotypic Interstitial Fibrils in Ehlers-Danlos 

Syndrome II. Journal of Biological Chemistry, 276, 13356-13364. 

Leporine Lens Epithelial Cells 

Ishida,I., Saika,S. and Ohnishi,Y. (2001) Effect of minoxidil on rabbit lens epithelial cell behavior in vitro and in situ. 

Graefe's Archive for Clinical and Experimental Ophthalmology, 239, 770-777. 

Leporine Lens Epithelial Cells 

Ishida,I.K.U. (2001) Experimental study on the efficacy of minoxidil in preventing postoperative capsular opacification. 

Journal of the Wakayama Medical Society, 52, 207-215.


Lee,C.G., Homer,R.J., Zhu,Z., Lanone,S., Wang,X., Koteliansky,V., Shipley,J.M., Gotwals,P., Noble,P. and Chen,Q. 

(2001) Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth 

Factor β1. Journal of Experimental Medicine, 194, 809-822. 

Human Left Ventricle Samples 

Li, Y. Y., Feng, Y., McTiernan, C. F., Pei, W., Moravec, C. S., Wang, P., Rosenblum, W., Kormos, R. L., and Feldman, 

A. M. (2001) Downregulation of Matrix Metalloproteinases and Reduction in Collagen Damage in the Failing 

Human Heart After Support With Left Ventricular Assist Devices. Circulation 104, 1147-1152. 

Murine Renal Tissue 

Mizuno,S., Matsumoto,K. and Nakamura,T. (2001) Hepatocyte growth factor suppresses interstitial fibrosis in a mouse 

model of obstructive nephropathy. Kidney International, 59, 1304-1314. 

Rat Fetal Lung Fibroblast (RFL-6) Cell Line 

Samimi,A. and Last,J.A. (2001) Inhibition of Lysyl Hydroxylase by Malathion and Malaoxon. Toxicology and Applied 

Pharmacology, 172, 203-209. 

2000 

Rat Aortic Smooth Muscle Cells and Pig Auricular Chondrocytes 

Brown, AN., Kim, BS., Alsberg,E. And Mooney,DJ.(2000) Combining Chondrocytes and Smooth Muscle Cells to Engineer 

Hybrid Soft Tissue Constructs. Tissue Engineering, 6, 297-305. 

Human Primary Fibroblast Cultures 

Kurasawa,K., Hirose,K., Sano,H., Endo,H., Shinkai,H., Nawata,Y., Takabayashi,K. and Iwamoto,I. (2000) Increased 

interleukin-17 production in patients with systemic sclerosis. Arthritis & Rheumatism, 43, 2455-2463. 

Murine Cardiac Left Ventricles 

Li,Y.Y., Feng,Y.Q., Kadokami,T., McTiernan,C.F., Draviam,R., Watkins,S.C. and Feldman,A.M. (2000) Myocardial 

extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be 

modulated by anti-tumor necrosis factor alpha therapy. Proceedings of the National Academy of Sciences, 97, 

12746. 

Murine Renal Tissue 

Mizuno,S. (2000) Reciprocal balance of hepatocyte growth factor and transforming growth factor-β 1 in renal fibrosis in 

mice. Kidney International, 57, 937. 


Tokuda,A., Itakura,M., Onai,N., Kimura,H., Kuriyama,T. and Matsushima,K. (2000) Pivotal Role of CCR1-Positive 

Leukocytes in Bleomycin-Induced Lung Fibrosis in Mice 1. The Journal of Immunology, 164, 2745-2751. 

1999 

Bovine Articular Chondrocyte Cultures 

Ioannidis,N., Kurz,B., Hansen,U. and Schünke,M. (1999) Influence of fulvic acid on the collagen secretion of bovine 

chondrocytes in vitro. Cell and Tissue Research, 297, 141-147.

Murine Dermis Samples 

Jimenez,P.A. and Rampy,M.A. (1999) Keratinocyte Growth Factor-2 Accelerates Wound Healing in Incisional Wounds. 

Journal of Surgical Research, 81, 238-242. 

Murine Tail Tendon 

Kuznetsova,N. and Leikin,S. (1999) Does the Triple Helical Domain of Type I Collagen Encode Molecular Recognition and 

Fiber Assembly while Telopeptides Serve as Catalytic Domains? Effect of Proteolytic Cleavage On Fibrillogenesis 

And On Collagen-Collagen Interaction In Fibers. Journal of Biological Chemistry, 274, 36083-36088. 


Natsume, M. (1999) Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6deficient 

mice. Journal of Leukocyte Biology 66, 601-608. 

Murine Bone Marrow Stromal Cells 

Notoya,K., Nagai,H., Oda,T., Gotoh,M., Hoshino,T., Muranishi,H., Taketomi,S., Sohda,T. and Makino,H. (1999) 

Enhancement of Osteogenesis In Vitro and In Vivo by a Novel Osteoblast Differentiation Promoting Compound, 

TAK-778. Journal of Pharmacology and Experimental Therapeutics, 290, 1054-1064. 


Shimizu,I., Mizobuchi,Y., Yasuda,M., Shiba,M., Ma,Y.R., Horie,T., Liu,F. and Ito,S. (1999) Inhibitory effect of oestradiol 

on activation of rat hepatic stellate cells in vivo and in vitro. Gut, 44, 127-136. 

Murine Liver Tissue and Primary cultures of Stellate cells and Hepatocytes 

Shimizu,I., Ma,Y.R., Mizobuchi,Y., Liu,F., Miura,T., Nakai,Y., Yasuda,M., Shiba,M., Horie,T. and Amagaya,S. (1999) 

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Human Osteoblasts 

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Human Amniotic Membrane Samples 

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