Infantile Hemangioma - CHU Sainte-Justine - SAAC

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How do β-blockers work?• We don’t know!• My 3 favorite theories:• Decreasing renin production• Regression via HIF-1α-mediated inhibition ofVEGF-A• Inhibition of migration of endothelial progenitorcells to hemangioma sitesItinteang T et al. Plast Reconstr Surg. 2011;128:499-507Chim H et al.Ann Surg. 2012;256:146-56Zou H-X et al. Cardiovasc Pathol 2012 Online early
What about TopicalBeta-Blockers?
Page 1 and 2: Infantile Hemangiomas:Approach and
Page 3 and 4: Overview• Which hemangiomas need
Page 5 and 6: How do we decidewhich hemangiomasto
Page 7 and 8: Risk of Segmentals• Segmental hem
Page 9 and 10: Residual skin changes inuntreated h
Page 11 and 12: Very Early Growth:Birth 1 year 2yea
Page 13 and 14: Very Early Growth:Study usingparent
Page 15 and 16: Timing of Initiation of Treatment~1
Page 17 and 18: Reevaluationat age 3 to 4 years•
Page 19 and 20: Propranolol as RxLéauté-Labrèze
Page 21 and 22: Results of Systematic Review• Res
Page 23 and 24: Propranolol ConsensusGuidelinesDrol
Page 25 and 26: Monitoring - All Patients• The pe
Page 27: Caveat• This information is based
Page 31 and 32: Topical Beta-Blockers:Experience in

Infantile Hemangioma - CHU Sainte-Justine - SAAC

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