Infantile Hemangioma - CHU Sainte-Justine - SAAC
Infantile Hemangioma - CHU Sainte-Justine - SAAC Infantile Hemangioma - CHU Sainte-Justine - SAAC
Beta-blockers for InfantileHemangiomas: 4 years later• More than 240 articles published• Systematic Review 41 case series with≥ 10 patients: Total of 1264 patients• 28% received prior Rx, most commonlyoral prednisolone• Propranolol initiated mean age of 6.6 mos,mean dose of 2.1 mg/kg/day• Mean duration Rx 6.4 months
Results of Systematic Review• Response rate was 98% (range 82 – 100%)• Response rates ~ comparable irrespectiveof anatomic sites e.g. periorbital, airway, etc.• Rebound growth in 17%• AE rate ~ 3 to 5%, with sleep changes andacrocyanosis being most common• Serious AEs rareMarqueling et al. Poster Soc Ped Dermatol July 2012
- Page 1 and 2: Infantile Hemangiomas:Approach and
- Page 3 and 4: Overview• Which hemangiomas need
- Page 5 and 6: How do we decidewhich hemangiomasto
- Page 7 and 8: Risk of Segmentals• Segmental hem
- Page 9 and 10: Residual skin changes inuntreated h
- Page 11 and 12: Very Early Growth:Birth 1 year 2yea
- Page 13 and 14: Very Early Growth:Study usingparent
- Page 15 and 16: Timing of Initiation of Treatment~1
- Page 17 and 18: Reevaluationat age 3 to 4 years•
- Page 19: Propranolol as RxLéauté-Labrèze
- Page 23 and 24: Propranolol ConsensusGuidelinesDrol
- Page 25 and 26: Monitoring - All Patients• The pe
- Page 27 and 28: Caveat• This information is based
- Page 29 and 30: What about TopicalBeta-Blockers?
- Page 31 and 32: Topical Beta-Blockers:Experience in
Results of Systematic Review• Response rate was 98% (range 82 – 100%)• Response rates ~ comparable irrespectiveof anatomic sites e.g. periorbital, airway, etc.• Rebound growth in 17%• AE rate ~ 3 to 5%, with sleep changes andacrocyanosis being most common• Serious AEs rareMarqueling et al. Poster Soc Ped Dermatol July 2012
Change language