Curriculum Vitae - Chemistry - University of South Florida

DIVYA RAMAMOORTHY14209 SHADOW MOSS LNAPT 201, TAMPA, FL 33613.PH: 813-317-5421E-Mail: dramamoo@mail.usf.edu******************************************************************************I am a graduate researcher, expecting Ph.D. in spring 2012, working in the area ofComputational/Medicinal Chemistry with a strong emphasis on drug discovery.RESEARCH EXPERIENCE:• Structure-Based Drug Design - Strong research background and interest in finding novelinhibitors for infectious diseases and cancer using structure based drug design protocols.• Molecular Dynamics Simulations – Experience in performing MD simulations to analyzestructural features of proteins to aid drug design and address potency, selectivity.• Organic Synthesis - Experience in the synthesis of organic molecules for protein targets in thesignal transduction pathways including Aurora Kinase, Bcl-xL, Shp2 and P53-Mdm2.TECHNICAL EXPERTISE:• Perl, TCL, C, C++, and Python• Schrodinger suite, Maestro, Allegrow, Pymol, VMD, Matlab• Desmond, NAMD, Gromacs• High Performance Liquid Chromatography (Agilent)• Gas Chromatography (Agilent)• Flash column chromatography (Biotage, Argonaut), Analytical and Preparative,optimized separation with appropriate solvent system and chromatographic parameters,TLC• NMR Spectroscopy: 1D and 2D homo- and heteronuclear NMR (Varian, Bruker)• IR, UV-vis Spectrometry• Microwave reactor (Biotage)• H-cube hydrogenator (Thalesnano)• Dynamic light scattering (Wyatt Dynapro Titan)• Protein purification• Library molecule synthesis

WORK EXPERIENCE2004-2005 Scientific Officer, United Phosphorous Limited, India.Synthesis of herbicides; Optimization for pilot plant synthesis.2003-2004 Scientist-B, Innovassynth Technologies Limited, India.Synthesis of drug intermediates; Optimization for pilot plant synthesis; Overviewof synthesis in pilot plant.EDUCATIONExpected Ph.D. Chemistry2012 University of South Florida, Advisor: Dr. Wayne C. GuidaArea of Research: Computational/Medicinal/Organic Chemistry.June 2009May 2002May 2000M.S. ChemistryUniversity of South Florida, Advisor: Dr. Nicholas J. LawrenceThesis: “Synthesis of Small Molecule Inhibitors Targeting SignalTransduction Pathways.”M.Sc. Applied ChemistryAnna University, India, studies on Chemistry and allied subjects (Industrialcatalysis, Polymer Chemistry, Molecular spectroscopy).Thesis: “Synthesis of carbazole derivatives: Synthesis of nitro and formylcarbazoles”, Advisor: Dr. P.T. Perumal, Central Leather Research Institute.B.Sc. ChemistryUniversity of Madras, studies on Chemistry (main subject), Physics (minorsubject) and Mathematics (minor subject)AWARDS, HONORS and SCHOLARSHIPSAug 2008Summer 2009, 2010, 2010Apr 2008Oct 2005Oct 1999Conference presentation grant, Student Government, USF.Fred L & Helen M Tharp Endowed Scholarship AwardSecond place, Graduate talk at Raymond Castle conference, USF.Best Chemist of the quarter (April-June 2005) InnovasynthTechnologies, India.Second place in state level Quiz competition, Loyola College,Chennai, India.

TEACHING ACTIVITIESTeaching assistant in the practical laboratory classes for students in General chemistry andOrganic chemistry at the University of South Florida. Handled Organic discussion classes forChemistry majors.CONFERENCES AND PRESENTATIONSApril 2006February 2007October 2007March 2008Apr 2008May 2008August 2008January 2009May 2009October 2009November 2010Poster, Raymond Castle Conference, Department of Chemistry, USF,Title: “Synthesis of substituted 4-aryl isoquinolones.”Poster, Scientific Retreat, Drug Discovery Unit, H. Lee. Moffitt CancerCenter & Research Institute at the University of South Florida, Tampa,Title: “Small molecules as potential inhibitors of Shp2 PTP.”Poster, Symposium on Molecular Diversity in Drug Design, Discoveryand Delivery, presented by the Florida Center of Excellence forBiomolecular Identification and Targeted Therapeutics, Title: “Synthesisof small molecule phosphatase inhibitors.”Poster, Scientific Retreat, Drug Discovery Unit, H. Lee. Moffitt CancerCenter & Research Institute at the University of South Florida, Tampa,Title: “Inhibitors of SHP2, a protein tyrosine phosphatase.”Graduate talk, Raymond Castle Conference, Department of Chemistry,USF, Title: “Inhibitors of SHP-2, a protein tyrosine phosphatase.”Talk, Florida ACS Meeting and Exposition, Orlando, Title: “Inhibitors ofSHP-2, a protein tyrosine phosphatase.”Poster, ACS National Meeting, Philadelphia, Title: "Inhibitors of SHP2, aprotein tyrosine phosphatase.”Talk, Chemistry Colloquium, department of Chemistry, USF, Title:“Small molecule inhibitors targeting signal transduction pathways.”Poster, Florida ACS Meeting and Exposition, Orlando, Title: “Low-modeStudies on FabH: Dimer.”Poster, Symposium on Molecular Diversity in Drug Design, Discoveryand Delivery, presented by the Florida Center of Excellence forBiomolecular Identification and Targeted Therapeutics, Title: “MDsimulation studies on FabH: Dimer interface.”Talk, Chemistry Colloquium, department of Chemistry, USF, Title:“FabH: Identification of a new binding site.”

April 2011Talk, Raymond Castle Conference, Department of Chemistry, USF, Title:“Identification of a new binding site in FabH using molecular dynamicssimulations and validation by docking studies”.