OptiMelt Automated Melting Point System - Stanford Research ...

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84 Pharmacopeia vs. Thermodynamic Melting Points Appendix Aresults, and within the accuracy of the measurement (±0.3 ºC), the thermodynamicmelting point results are independent of the ramp rate as expected.Ramp Rate, r[°C/min]Clear Point [°C](MP pharma )MP therm = MP pharma –ThermoCF . r 1/2[°C]0.1 134.2 133.60.2 134.4 133.40.5 134.9 133.61 135.4 133.52 136.2 133.55 137.9 133.6Table 7. Clear and Thermodynamic Melting Point of Phenacetin at various ramp rates(ThermoCF = 1.9).TipThermodynamic corrections, ∆T(r), are automatically appended to melting point Reportsif Thermo MP is set to Calculate in the Options menu of the Melt Screen.OptiMelt Automated Melting Point System
Melting Point Certified Reference Standards 85Appendix BMelting Point Certified ReferenceStandardsWhat is a Certified Reference Standard?Certified Reference Standards (CRSs) are high-purity chemicals certified by National,Local or International Standards Laboratories and Pharmacopeia Conventions, producedand tested according to well established and easy-to-reproduce procedures.Use CRSs for calibration and determination of acceptability of melting point instrumentsincluding OptiMelt.General Guidelines and Recommendations• Use CRSs obtained from reputable Standards and Pharmacopeia Laboratories.• Use CRSs with Certificates of Measurement including records of:(1) Lot/Batch Identification number (for traceability)(2) Purity specification (analysis method, purity levels, etc.)(3) Detailed description of the instrumental setup used for the melting pointdetermination: type of instrument, manual or automatic detection, hot bath ormetal block oven, capillary tube dimensions, amount/height of sample packed,compaction method, etc.(4) Preconditioning of the sample (i.e. drying, grinding, etc).(5) Detailed heating conditions, including initial temperature, ramping rate and anyspecial comments required to properly reproduce the melting conditions used bythe standards laboratory to certify the compound. Alternatively, a reference to astandardized melting point determination method must be included.(6) Melting points and melting point ranges with well characterized uncertaintyerrors.• Whenever possible, choose the CRSs with the smallest uncertainty errors. Rememberthat the accuracy of your OptiMelt is only as good as the accuracy of the standardsused for its temperature scale calibration. Note: As a general rule, avoid CRSsleading to uncertainty errors larger than 0.5 °C.• Do not assume that a CRS compatible with one specific pharmacopeia procedure iscompatible with the requirements of a different pharmacopeia protocol. For example,OptiMelt Automated Melting Point System
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iiSafety and Preparation For Use•
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ivSafety and Preparation For UseOpt
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viContentsMelting Point Range 57Mel
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viiiFront Panel OverviewReady LEDA
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xBack Panel OverviewPrinterOptiMelt
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xiiSpecificationsOptiMelt Automated
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2 Getting Started Chapter 1• Repl
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4 Getting Started Chapter 1Ceramic
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6 Getting Started Chapter 1Principl
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8 Getting Started Chapter 1Quick St
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10 Getting Started Chapter 18. Preh
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12 Getting Started Chapter 1Touch t
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14 Getting Started Chapter 1If none
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16 Getting Started Chapter 1• Tou
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18 Getting Started Chapter 1OptiMel
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20 Displays and Menus Chapter 2Nume
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22 Melt Screen Chapter 2Melt Screen
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Chapter 2 Melt Screen 25Touch the T
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Chapter 2 Melt Screen 27Select Newe
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Chapter 2 Melt Screen 29Select Came
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Chapter 2 Melt Screen 31Options Men
Page 47 and 48: Chapter 2 Melt Screen 33The thermod
Page 49 and 50: Chapter 2 Timer Screen 35ResetTouch
Page 51 and 52: Chapter 2 T Meter Screen 37Alarm Lo
Page 53 and 54: Chapter 2 System Screen 39System Sc
Page 55 and 56: Chapter 2 System Screen 41The Print
Page 57 and 58: Chapter 2 System Screen 43Screen Me
Page 59 and 60: Melting Point Determination 45Chapt
Page 61 and 62: Chapter 3 Melting Point Determinati
Page 77 and 78: Maintenance and Calibration 63Chapt
Page 79 and 80: Chapter 4 Maintenance and Calibrati
Page 91 and 92: Pharmacopeia vs. Thermodynamic Melt
Page 93 and 94: Appendix A Pharmacopeia vs. Thermod
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Page 101 and 102: Appendix B Melting Point Certified
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Page 105 and 106: Using Melt Graphs 91Appendix CUsing
Page 107 and 108: Appendix C Using Melt Graphs 93The
Page 109 and 110: OptiMelt Remote Programming 95Appen
Page 111 and 112: Appendix D OptiMelt Remote Programm
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