OptiMelt Automated Melting Point System - Stanford Research ...

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76 Maintenance and Calibration Chapter 4Remove the glass window from the heating block periodically and wipe it clean withalcohol or acetone. Replace the window with a new one if it will not come completelyclean.OptiMelt Automated Melting Point System
Pharmacopeia vs. Thermodynamic Melting Points 77Appendix APharmacopeia vs. ThermodynamicMelting Point DeterminationsPharmacopeia Melting PointThe procedural rules for melting point determinations are defined in the pharmacopeias.The medical handbooks include minimum requirements for the design of the meltingpoint apparatus and for performing the measurements. Automated melting pointdetermination procedures are generally included. Very often, the pharmacopeias also listspecial methods for difficult or unusual cases of melting point determination.The pharmacopeias regard the capillary technique as the standard method for meltingpoint determination. In this method, thin glass capillary tubes containing packed samplesof the substance are introduced into a heating stand that is continuously being heated up.The capillary technique is the standard method used for melting pointdeterminations in most organic and pharmaceutical chemistry laboratories.The procedures for melting point determinations in the pharmacopeias call for a fixedrate of temperature rise in the “heating stand” (liquid bath and/or metal block), typicallybetween 0.2 and 2 °C/min, within a temperature range that brackets the expected meltingtemperature of the compound. The oven continues to heat at a constant rate until thesample is completely melted – i.e. clear point. In determining the melting point – thetemperature on the thermometer at the clear point (and/or sometimes at the meniscuspoint) is recorded. This is not the temperature of the sample itself, but rather that of theheating stand where the thermometer is located – i.e. the temperature is determined bythe heating medium.When different heating rates are used for determining the melting point of a sample, thevalues obtained for the clear point are dependent on the temperature ramping rate.Because the heat transfer from the heating stand to the sample cannot be increasedproportionally to the temperature ramping rate, the temperature in the heating stand risesto a higher level with faster rates of heat increase than it does with lower rates. As aresult, the faster the temperature is ramped, the higher the clear points are found to be.Due to this dependence on heating rate, measurements taken for melting points arecomparable with one another only if they were taken using the same ramping rates. Anyvariance from the temperature ramping rates specified by pharmacopeia procedures mustbe properly recorded for Good Laboratory Practice documentation.OptiMelt Automated Melting Point System
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iiSafety and Preparation For Use•
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ivSafety and Preparation For UseOpt
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viContentsMelting Point Range 57Mel
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viiiFront Panel OverviewReady LEDA
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xBack Panel OverviewPrinterOptiMelt
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xiiSpecificationsOptiMelt Automated
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2 Getting Started Chapter 1• Repl
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4 Getting Started Chapter 1Ceramic
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6 Getting Started Chapter 1Principl
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8 Getting Started Chapter 1Quick St
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10 Getting Started Chapter 18. Preh
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12 Getting Started Chapter 1Touch t
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14 Getting Started Chapter 1If none
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16 Getting Started Chapter 1• Tou
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18 Getting Started Chapter 1OptiMel
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20 Displays and Menus Chapter 2Nume
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22 Melt Screen Chapter 2Melt Screen
Page 39 and 40: Chapter 2 Melt Screen 25Touch the T
Page 41 and 42: Chapter 2 Melt Screen 27Select Newe
Page 43 and 44: Chapter 2 Melt Screen 29Select Came
Page 45 and 46: Chapter 2 Melt Screen 31Options Men
Page 47 and 48: Chapter 2 Melt Screen 33The thermod
Page 49 and 50: Chapter 2 Timer Screen 35ResetTouch
Page 51 and 52: Chapter 2 T Meter Screen 37Alarm Lo
Page 53 and 54: Chapter 2 System Screen 39System Sc
Page 55 and 56: Chapter 2 System Screen 41The Print
Page 57 and 58: Chapter 2 System Screen 43Screen Me
Page 59 and 60: Melting Point Determination 45Chapt
Page 61 and 62: Chapter 3 Melting Point Determinati
Page 77 and 78: Maintenance and Calibration 63Chapt
Page 79 and 80: Chapter 4 Maintenance and Calibrati
Page 89: Chapter 4 Maintenance and Calibrati
Page 93 and 94: Appendix A Pharmacopeia vs. Thermod
Page 99 and 100: Melting Point Certified Reference S
Page 101 and 102: Appendix B Melting Point Certified
Page 103 and 104: Appendix B Melting Point Certified
Page 105 and 106: Using Melt Graphs 91Appendix CUsing
Page 107 and 108: Appendix C Using Melt Graphs 93The
Page 109 and 110: OptiMelt Remote Programming 95Appen
Page 111 and 112: Appendix D OptiMelt Remote Programm
Page 123: Appendix D OptiMelt Remote Programm
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