OptiMelt Automated Melting Point System - Stanford Research ...
OptiMelt Automated Melting Point System - Stanford Research ... OptiMelt Automated Melting Point System - Stanford Research ...
32 Melt Screen Chapter 2StatsOptions: Skip (default) or CalculateEnable or disable statistical calculations on the automated results.If enough sample is available, and three capillaries of the same substance can be analyzedat the same time, OptiMelt can be directed to calculate the average of the three automateddeterminations providing a more accurate result for the melting point temperatures.Select Skip to disable statistical calculations on the automated results.Select Calculate to enable statistical calculations on the automated results. The averagedresults for the three identical samples are included in the Report.PrintoutOptions: Manual (default) or AutoChoose between Manual or Automatic printout of the final Test Report at the end of amelt.Manual means that the user must manually display and printout Reports from the Reportscreen after the melting point determination is completed.Auto means that OptiMelt automatically prints out a Report at the end of a melting pointdetermination whenever a printer is connected to the instrument.BeepOptions: Off or On (default)Enable or disable audio beeps.On means that distinctive beeps are sounded every time an important task is completedby OptiMelt or user attention is required.Off means that no beeps are sounded during the melting point analysis.Thermo MPOptions: Skip (default) or CalculateEnable or disable calculation of thermodynamic corrections for the melting pointdetermination.Select Skip to disable thermodynamic correction calculations.Select Calculate to enable thermodynamic correction calculations.OptiMelt Automated Melting Point System
Chapter 2 Melt Screen 33The thermodynamic correction is directly proportional to the square root of the rampingRate, and to the Thermodynamic Correction Factor (ThermoCF) for the substance beinganalyzed: ∆T(r) = (ThermoCF) · r 1/2 .The thermodynamic correction, ∆T(r), is listed in the test Report and must be subtractedfrom the clear point to provide an estimate of the true thermodynamic melting point ofthe sample.Thermodynamic correction factors are stored in analysis method files.Please consult Appendix A of this manual for details on the calculation ofThermodynamic Melting points.Thermo Corr. Factor (ThermoCF)Range: 0.1 to 10, default: 1.0Enter the Thermodynamic Correction Factor for the sample being analyzed.A substance-specific Thermodynamic Correction Factor, ThermoCF, can be programmedinto the OptiMelt and used by the instrument to automatically calculate ThermodynamicCorrections, ∆T(r) = (ThermoCF) · r 1/2 , at the end of each melting point determination.Theoretically, the value of ThermoCF is related to the heat conductivity and the heat offusion of the substance being analyzed. It is also affected by the sample preparationprocedure and the geometry of the oven and capillaries. Experimentation has shown thatwith OptiMelt, a good approximation to ThermoCF is a value of 1.0. However, accurateresults require calibration. Consult Appendix A for a step-by-step calibration procedurefor the ThermoCF factor.Thermodynamic correction factors are included in all analysis method files and displayedin all test Reports.Oven offTouch the Oven off button to turn the oven off. The heater is turned off and the ovencools down.Use this button to turn off the oven at the end of your last analysis or at the end of theday. This leaves the instrument in a safe cool state.TimeoutDefault: 00:30:00Enter an oven timeout period.A heated oven, idling at the Start temperature, will automatically shut down after thespecified Timeout period. This is a very useful and important safety feature built intoyour OptiMelt.OptiMelt Automated Melting Point System
- Page 4 and 5: iiSafety and Preparation For Use•
- Page 6 and 7: ivSafety and Preparation For UseOpt
- Page 8 and 9: viContentsMelting Point Range 57Mel
- Page 10 and 11: viiiFront Panel OverviewReady LEDA
- Page 12 and 13: xBack Panel OverviewPrinterOptiMelt
- Page 14 and 15: xiiSpecificationsOptiMelt Automated
- Page 16 and 17: 2 Getting Started Chapter 1• Repl
- Page 18 and 19: 4 Getting Started Chapter 1Ceramic
- Page 20 and 21: 6 Getting Started Chapter 1Principl
- Page 22 and 23: 8 Getting Started Chapter 1Quick St
- Page 24 and 25: 10 Getting Started Chapter 18. Preh
- Page 26 and 27: 12 Getting Started Chapter 1Touch t
- Page 28 and 29: 14 Getting Started Chapter 1If none
- Page 30 and 31: 16 Getting Started Chapter 1• Tou
- Page 32 and 33: 18 Getting Started Chapter 1OptiMel
- Page 34 and 35: 20 Displays and Menus Chapter 2Nume
- Page 36: 22 Melt Screen Chapter 2Melt Screen
- Page 39 and 40: Chapter 2 Melt Screen 25Touch the T
- Page 41 and 42: Chapter 2 Melt Screen 27Select Newe
- Page 43 and 44: Chapter 2 Melt Screen 29Select Came
- Page 45: Chapter 2 Melt Screen 31Options Men
- Page 49 and 50: Chapter 2 Timer Screen 35ResetTouch
- Page 51 and 52: Chapter 2 T Meter Screen 37Alarm Lo
- Page 53 and 54: Chapter 2 System Screen 39System Sc
- Page 55 and 56: Chapter 2 System Screen 41The Print
- Page 57 and 58: Chapter 2 System Screen 43Screen Me
- Page 59 and 60: Melting Point Determination 45Chapt
- Page 61 and 62: Chapter 3 Melting Point Determinati
- Page 63 and 64: Chapter 3 Melting Point Determinati
- Page 65 and 66: Chapter 3 Melting Point Determinati
- Page 67 and 68: Chapter 3 Melting Point Determinati
- Page 69 and 70: Chapter 3 Melting Point Determinati
- Page 71 and 72: Chapter 3 Melting Point Determinati
- Page 73 and 74: Chapter 3 Melting Point Determinati
- Page 75 and 76: Chapter 3 Melting Point Determinati
- Page 77 and 78: Maintenance and Calibration 63Chapt
- Page 79 and 80: Chapter 4 Maintenance and Calibrati
- Page 81 and 82: Chapter 4 Maintenance and Calibrati
- Page 83 and 84: Chapter 4 Maintenance and Calibrati
- Page 85 and 86: Chapter 4 Maintenance and Calibrati
- Page 87 and 88: Chapter 4 Maintenance and Calibrati
- Page 89 and 90: Chapter 4 Maintenance and Calibrati
- Page 91 and 92: Pharmacopeia vs. Thermodynamic Melt
- Page 93 and 94: Appendix A Pharmacopeia vs. Thermod
- Page 95 and 96: Appendix A Pharmacopeia vs. Thermod
32 Melt Screen Chapter 2StatsOptions: Skip (default) or CalculateEnable or disable statistical calculations on the automated results.If enough sample is available, and three capillaries of the same substance can be analyzedat the same time, <strong>OptiMelt</strong> can be directed to calculate the average of the three automateddeterminations providing a more accurate result for the melting point temperatures.Select Skip to disable statistical calculations on the automated results.Select Calculate to enable statistical calculations on the automated results. The averagedresults for the three identical samples are included in the Report.PrintoutOptions: Manual (default) or AutoChoose between Manual or Automatic printout of the final Test Report at the end of amelt.Manual means that the user must manually display and printout Reports from the Reportscreen after the melting point determination is completed.Auto means that <strong>OptiMelt</strong> automatically prints out a Report at the end of a melting pointdetermination whenever a printer is connected to the instrument.BeepOptions: Off or On (default)Enable or disable audio beeps.On means that distinctive beeps are sounded every time an important task is completedby <strong>OptiMelt</strong> or user attention is required.Off means that no beeps are sounded during the melting point analysis.Thermo MPOptions: Skip (default) or CalculateEnable or disable calculation of thermodynamic corrections for the melting pointdetermination.Select Skip to disable thermodynamic correction calculations.Select Calculate to enable thermodynamic correction calculations.<strong>OptiMelt</strong> <strong>Automated</strong> <strong>Melting</strong> <strong>Point</strong> <strong>System</strong>